Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2015 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2015 Volume 9 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Impact of obesity upon prostate cancer-associated mortality: A meta‑analysis of 17 cohort studies

  • Authors:
    • Xiaoyi Zhang
    • Guiqin Zhou
    • Bo Sun
    • Guohua Zhao
    • Dezhong Liu
    • Jiage Sun
    • Chuanhai Liu
    • Hui Guo
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Artillery General Hospital People's Liberation Army, Beijing 100088, P.R. China, Center of Integrated Traditional Chinese and Western Medicine, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing 100088, P.R. China
  • Pages: 1307-1312
    |
    Published online on: December 31, 2014
       https://doi.org/10.3892/ol.2014.2841
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A number of epidemiological studies have suggested that obesity is associated, albeit inconsistently, with the incidence of prostate cancer (PCa). In order to provide a quantitative assessment of this association, the present study examined the correlation between obesity and the incidence and associated mortalities of PCa in an updated meta‑analysis of cohort studies. The cohort studies were identified by searching the EMBASE and MEDLINE databases on January 1, 2014. The summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using random‑effects models. In total, 17 studies, which included 3,569,926 individuals overall, were selected according to predefined inclusion criteria. Based upon the results of the random‑effects models, obesity was not significantly correlated with the incidence of PCa (RR, 1.00; 95% CI, 0.95‑1.06). However, further analysis revealed that obesity was significantly correlated with an increased risk of aggressive PCa (RR, 1.14; 95% CI, 1.04‑1.25). Furthermore, an increased risk of PCa‑associated mortality was significantly associated with obesity (RR, 1.24; 95% CI, 1.15‑2.33), without any heterogeneity between the studies (I2=0.0%; P=0.847). The present study provides preliminary evidence to demonstrate that obesity is a significant risk factor for aggressive PCa and PCa‑specific mortality. The low survival rates observed among obese males with PCa may be a likely explanation for this association.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Jemal A, Bray F, Center MM, et al: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Saad F and Pantel K: The current role of circulating tumor cells in the diagnosis and management of bone metastases in advanced prostate cancer. Future Oncol. 8:321–331. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Pontes-Júnior J, Reis ST, et al: Association between integrin expression and prognosis in localized prostate cancer. Prostate. 70:1189–1195. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Global Health Risks. Mortality and Burden of Disease Attributable to Selected Major Risks. Geneva: World Health Organization; 2009, http://www.who.int/healthinfo/global_burden_disease/GlobalHealthRisks_report_full.pdf. Accessed March 19, 2013

5 

Wang YC, McPherson K, Marsh T, Gortmaker SL and Brown M: Health and economic burden of the projected obesity trends in the USA and the UK. Lancet. 378:815–825. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Freedland SJ, Bañez LL, Sun LL, et al: Obese men have higher-grade and larger tumors: an analysis of the duke prostate center database. Prostate Cancer Prostatic Dis. 12:259–263. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Cao Y and Ma J: Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis. Cancer Prev Res (Phila). 4:486–501. 2011. View Article : Google Scholar

8 

Mallah KN, DiBlasio CJ, Rhee AC, et al: Body mass index is weakly associated with, and not a helpful predictor of, disease progression in men with clinically localized prostate carcinoma treated with radical prostatectomy. Cancer. 103:2030–2034. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Discacciati A, Orsini N and Wolk A: Body mass index and incidence of localized and advanced prostate cancer - a dose-response meta-analysis of prospective studies. Ann Oncol. 23:1665–1671. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Stroup DF, Berlin JA, Morton SC, et al: Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 283:2008–2012. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Cota GF, de Sousa MR, Fereguetti TO and Rabello A: Efficacy of anti-leishmania therapy in visceral leishmaniasis among HIV infected patients: a systematic review with indirect comparison. PLoS Negl Trop Dis. 7:e21952013. View Article : Google Scholar : PubMed/NCBI

12 

Zwahlen M, Renehan A and Egger M: Meta-analysis in medical research: potentials and limitations. Urol Oncol. 26:320–329. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Häggström C1, Stocks T, Ulmert D, et al: Prospective study on metabolic factors and risk of prostate cancer. Cancer. 118:6199–6206. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Bassett JK, Severi G, Baglietto L, et al: Weight change and prostate cancer incidence and mortality. Int J Cancer. 131:1711–1719. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Dehal A, Garrett T, Tedders SH, et al: Body mass index and death rate of colorectal cancer among a national cohort of U.S. adults. Nutr Cancer. 63:1218–1225. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Burton A, Martin R, Galobardes B, et al: Young adulthood body mass index and risk of cancer in later adulthood: historical cohort study. Cancer Causes Control. 21:2069–2077. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Stocks T, Hergens MP, Englund A, Ye W and Stattin P: Blood pressure, body size and prostate cancer risk in the Swedish Construction Workers cohort. Int J Cancer. 127:1660–1668. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Pischon T, Boeing H, Weikert S, et al: Body size and risk of prostate cancer in the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev. 17:3252–3261. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Giovannucci E1, Liu Y, Platz EA, Stampfer MJ and Willett WC: Risk factors for prostate cancer incidence and progression in the health professionals follow-up study. Int J Cancer. 121:1571–1578. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Littman AJ, White E and Kristal AR: Anthropometrics and prostate cancer risk. Am J Epidemiol. 165:1271–1279. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Wright ME, Chang SC, Schatzkin A, et al: Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality. Cancer. 109:675–684. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Engeland A, Tretli S and Bjørge T: Height, body mass index, and prostate cancer: a follow-up of 950000 Norwegian men. Br J Cancer. 89:1237–1242. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Calle EE, Rodriguez C, Walker-Thurmond K and Thun MJ: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 348:1625–1638. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Rodriguez C, Patel AV, Calle EE, et al: Body mass index, height, and prostate cancer mortality in two large cohorts of adult men in the United States. Cancer Epidemiol Biomarkers Prev. 10:345–353. 2001.PubMed/NCBI

25 

Andersson SO, Wolk A, Bergström R, et al: Body size and prostate cancer: a 20-year follow-up study among 135006 Swedish construction workers. J Natl Cancer Inst. 89:385–389. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Schuurman AG, Goldbohm RA, Dorant E and van den Brandt PA: Anthropometry in relation to prostate cancer risk in the Netherlands Cohort Study. Am J Epidemiol. 151:541–549. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Lee IM, Sesso HD and Paffenbarger RS Jr: A prospective cohort study of physical activity and body size in relation to prostate cancer risk (United States). Cancer Causes Control. 12:187–193. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Cerhan JR, Torner JC, Lynch CF, et al: Association of smoking, body mass, and physical activity with risk of prostate cancer in the Iowa 65+ Rural Health Study (United States). Cancer Causes Control. 8:229–238. 1997. View Article : Google Scholar : PubMed/NCBI

29 

Hajian-Tilaki KO, Gholizadehpasha AR, Bozorgzadeh S and Hajian-Tilaki E: Body mass index and waist circumference are predictor biomarkers of breast cancer risk in Iranian women. Med Oncol. 28:1296–1301. 2011. View Article : Google Scholar

30 

Puente Vazquez J, Grande Pulido E and Anton Aparicio LM: Cytokine and endocrine signaling in prostate cancer. Med Oncol. 29:1956–1963. 2012. View Article : Google Scholar

31 

MacInnis RJ and English DR: Body size and composition and prostate cancer risk: systematic review and meta-regression analysis. Cancer Causes Control. 17:989–1003. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Baillargeon J, Platz EA, Rose DP, et al: Obesity, adipokines, and prostate cancer in a prospective population-based study. Cancer Epidemiol Biomarkers Prev. 15:1331–1335. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Porter MP and Stanford JL: Obesity and the risk of prostate cancer. Prostate. 62:316–321. 2005. View Article : Google Scholar

34 

Gong Z, Neuhouser ML, Goodman PJ, et al: Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev. 15:1977–1983. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Rodriguez C, Freedland SJ, Deka A, et al: Body mass index, weight change, and risk of prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev. 16:63–69. 2007. View Article : Google Scholar

36 

Roberts DL, Dive C and Renehan AG: Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med. 61:301–316. 2010. View Article : Google Scholar

37 

Hu Q, Gou Y, Sun C, et al: The prognostic value of C-reactive protein in renal cell carcinoma: A systematic review and meta-analysis. Urol Oncol. 32:50.e1–50.e8. 2014. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Zhou G, Sun B, Zhao G, Liu D, Sun J, Liu C and Guo H: Impact of obesity upon prostate cancer-associated mortality: A meta‑analysis of 17 cohort studies. Oncol Lett 9: 1307-1312, 2015.
APA
Zhang, X., Zhou, G., Sun, B., Zhao, G., Liu, D., Sun, J. ... Guo, H. (2015). Impact of obesity upon prostate cancer-associated mortality: A meta‑analysis of 17 cohort studies. Oncology Letters, 9, 1307-1312. https://doi.org/10.3892/ol.2014.2841
MLA
Zhang, X., Zhou, G., Sun, B., Zhao, G., Liu, D., Sun, J., Liu, C., Guo, H."Impact of obesity upon prostate cancer-associated mortality: A meta‑analysis of 17 cohort studies". Oncology Letters 9.3 (2015): 1307-1312.
Chicago
Zhang, X., Zhou, G., Sun, B., Zhao, G., Liu, D., Sun, J., Liu, C., Guo, H."Impact of obesity upon prostate cancer-associated mortality: A meta‑analysis of 17 cohort studies". Oncology Letters 9, no. 3 (2015): 1307-1312. https://doi.org/10.3892/ol.2014.2841
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Zhou G, Sun B, Zhao G, Liu D, Sun J, Liu C and Guo H: Impact of obesity upon prostate cancer-associated mortality: A meta‑analysis of 17 cohort studies. Oncol Lett 9: 1307-1312, 2015.
APA
Zhang, X., Zhou, G., Sun, B., Zhao, G., Liu, D., Sun, J. ... Guo, H. (2015). Impact of obesity upon prostate cancer-associated mortality: A meta‑analysis of 17 cohort studies. Oncology Letters, 9, 1307-1312. https://doi.org/10.3892/ol.2014.2841
MLA
Zhang, X., Zhou, G., Sun, B., Zhao, G., Liu, D., Sun, J., Liu, C., Guo, H."Impact of obesity upon prostate cancer-associated mortality: A meta‑analysis of 17 cohort studies". Oncology Letters 9.3 (2015): 1307-1312.
Chicago
Zhang, X., Zhou, G., Sun, B., Zhao, G., Liu, D., Sun, J., Liu, C., Guo, H."Impact of obesity upon prostate cancer-associated mortality: A meta‑analysis of 17 cohort studies". Oncology Letters 9, no. 3 (2015): 1307-1312. https://doi.org/10.3892/ol.2014.2841
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team