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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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March-2015 Volume 9 Issue 3

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma

  • Authors:
    • Manabu Hoshi
    • Naoto Oebisu
    • Jun Takada
    • Tdashi Iwai
    • Hiroaki Nakamura

  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan
  • Pages: 1409-1411
    |
    Published online on: January 5, 2015
       https://doi.org/10.3892/ol.2015.2844
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Abstract

The current study presents the case of a 59‑year‑old male with advanced‑stage renal cell carcinoma and bone metastases in the proximal femur and ilium (cT3aN3M1; stage IV). Resection of the primary renal cell cancer and palliative surgery with a γ‑nail for an impending fracture of the right proximal femur were performed, followed by radiotherapy. Sorafenib, a multi‑kinase inhibitor that blocks the raf and tyrosine kinases of the vascular endothelial and platelet‑derived growth factor receptors, was administered for 9 months, resulting in a marked improvement in the metastatic ilium and a reduction in the extent of the lung metastases. The patient suffered minor adverse effects, including a skin rash and mild diarrhea, but remained alive at the time of follow‑up at 36 months post‑surgery. Sorafenib demonstrated efficacy against the bone metastasis of metastatic renal cell carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Hoshi M, Oebisu N, Takada J, Iwai T and Nakamura H: Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma. Oncol Lett 9: 1409-1411, 2015.
APA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., & Nakamura, H. (2015). Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma. Oncology Letters, 9, 1409-1411. https://doi.org/10.3892/ol.2015.2844
MLA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Nakamura, H."Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma". Oncology Letters 9.3 (2015): 1409-1411.
Chicago
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Nakamura, H."Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma". Oncology Letters 9, no. 3 (2015): 1409-1411. https://doi.org/10.3892/ol.2015.2844
Copy and paste a formatted citation
x
Spandidos Publications style
Hoshi M, Oebisu N, Takada J, Iwai T and Nakamura H: Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma. Oncol Lett 9: 1409-1411, 2015.
APA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., & Nakamura, H. (2015). Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma. Oncology Letters, 9, 1409-1411. https://doi.org/10.3892/ol.2015.2844
MLA
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Nakamura, H."Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma". Oncology Letters 9.3 (2015): 1409-1411.
Chicago
Hoshi, M., Oebisu, N., Takada, J., Iwai, T., Nakamura, H."Case report demonstrating effectiveness of sorafenib in multiple lung and bone metastases of renal cell carcinoma". Oncology Letters 9, no. 3 (2015): 1409-1411. https://doi.org/10.3892/ol.2015.2844
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