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Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients

  • Authors:
    • Gul Alco
    • Atilla Bozdogan
    • Derya Selamoglu
    • Kezban Nur Pilancı
    • Sıtkı Tuzlalı
    • Cetin Ordu
    • Sefik Igdem
    • Sait Okkan
    • Maktav Dincer
    • Gokhan Demir
    • Vahit Ozmen
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Gayrettepe Florence Nightingale Hospital, Gayrettepe, Istanbul 34349, Turkey, Department of Biostatistics, Istanbul Florence Nightingale Hospital, Gayrettepe, Istanbul 34349, Turkey, Department of Breast Surgery, Istanbul Florence Nightingale Hospital, Gayrettepe, Istanbul 34349, Turkey, Department of Medical Oncology, Istanbul Bilim University, Gayrettepe, Istanbul 34349, Turkey, Department of Pathology, Istanbul Florence Nightingale Hospital, Gayrettepe, Istanbul 34349, Turkey, Department of Radiation Oncology, Istanbul Bilim University, Gayrettepe, Istanbul 34349, Turkey
    Copyright: © Alco et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1046-1054
    |
    Published online on: January 7, 2015
       https://doi.org/10.3892/ol.2015.2852
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Abstract

The aim of the present study was to identify the optimal Ki-67 cut-off value in breast cancer (BC) patients, and investigate the association of Ki‑67 expression levels with other prognostic factors. Firstly, a retrospective search was performed to identify patients with stage I-III BC (n=462). A range of Ki-67 index values were then assigned to five groups (<10, 10-14, 15-19, 20-24 and ≥25%). The correlation between the Ki-67 index and other prognostic factors [age, tumor type, histological and nuclear grade, tumor size, multifocality, an in situ component, lymphovascular invasion (LVI), estrogen and progesterone receptor (ER/PR) expression, human epidermal growth factor receptor (HER-2) status, axillary involvement and tumor stage] were investigated in each group. The median Ki-67 value was revealed to be 20% (range, 1-95%). A young age (≤40 years old), tumor type, size and grade, LVI, ER/PR negativity and HER-2 positivity were revealed to be associated with the Ki-67 level. Furthermore, Ki-67 was demonstrated to be negatively correlated with ER/PR expression (P<0.001), but positively correlated with tumor size (P<0.001). The multivariate analysis revealed that a Ki-67 value of ≥15% was associated with the largest number of poor prognostic factors (P=0.036). In addition, a Ki-67 value of ≥15% was identified to be statistically significant in association with certain luminal subtypes. The rate of disease‑free survival was higher in patients with luminal A subtype BC (P=0.036). Following the correlation analysis for the Ki-67 index and the other prognostic factors, a Ki-67 value of ≥15% was revealed to be the optimal cut-off level for BC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Alco G, Bozdogan A, Selamoglu D, Pilancı KN, Tuzlalı S, Ordu C, Igdem S, Okkan S, Dincer M, Demir G, Demir G, et al: Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients. Oncol Lett 9: 1046-1054, 2015.
APA
Alco, G., Bozdogan, A., Selamoglu, D., Pilancı, K.N., Tuzlalı, S., Ordu, C. ... Ozmen, V. (2015). Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients. Oncology Letters, 9, 1046-1054. https://doi.org/10.3892/ol.2015.2852
MLA
Alco, G., Bozdogan, A., Selamoglu, D., Pilancı, K. N., Tuzlalı, S., Ordu, C., Igdem, S., Okkan, S., Dincer, M., Demir, G., Ozmen, V."Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients". Oncology Letters 9.3 (2015): 1046-1054.
Chicago
Alco, G., Bozdogan, A., Selamoglu, D., Pilancı, K. N., Tuzlalı, S., Ordu, C., Igdem, S., Okkan, S., Dincer, M., Demir, G., Ozmen, V."Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients". Oncology Letters 9, no. 3 (2015): 1046-1054. https://doi.org/10.3892/ol.2015.2852
Copy and paste a formatted citation
x
Spandidos Publications style
Alco G, Bozdogan A, Selamoglu D, Pilancı KN, Tuzlalı S, Ordu C, Igdem S, Okkan S, Dincer M, Demir G, Demir G, et al: Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients. Oncol Lett 9: 1046-1054, 2015.
APA
Alco, G., Bozdogan, A., Selamoglu, D., Pilancı, K.N., Tuzlalı, S., Ordu, C. ... Ozmen, V. (2015). Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients. Oncology Letters, 9, 1046-1054. https://doi.org/10.3892/ol.2015.2852
MLA
Alco, G., Bozdogan, A., Selamoglu, D., Pilancı, K. N., Tuzlalı, S., Ordu, C., Igdem, S., Okkan, S., Dincer, M., Demir, G., Ozmen, V."Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients". Oncology Letters 9.3 (2015): 1046-1054.
Chicago
Alco, G., Bozdogan, A., Selamoglu, D., Pilancı, K. N., Tuzlalı, S., Ordu, C., Igdem, S., Okkan, S., Dincer, M., Demir, G., Ozmen, V."Clinical and histopathological factors associated with Ki-67 expression in breast cancer patients". Oncology Letters 9, no. 3 (2015): 1046-1054. https://doi.org/10.3892/ol.2015.2852
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