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Article

Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients

  • Authors:
    • Yu‑Pei Chen
    • Chen Chen
    • Zhuo‑Yao Mai
    • Jin Gao
    • Lu‑Jun Shen
    • Bing‑Cheng Zhao
    • Meng‑Kun Chen
    • Gang Chen
    • Fang Yan
    • Tong‑Yi Huang
    • Yun‑Fei Xia
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Oncology in Southern China, Sun Yat‑Sen University, Guangzhou, Guangdong, P.R. China, Department of Radiation Oncology, Anhui Provincial Hospital, Hefei, Anhui, P.R. China
  • Pages: 1458-1466
    |
    Published online on: January 13, 2015
       https://doi.org/10.3892/ol.2015.2872
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Abstract

The aim of the present study was to investigate the prognostic value of different pretreatment platelet (PLT) counts on the treatment outcome in nasopharyngeal carcinoma (NPC) patients receiving concurrent chemoradiotherapy (CCRT) or radiotherapy (RT) alone. A total of 1,501 NPC patients, including 412 receiving CCRT and 1,089 receiving RT, were enrolled in the present study. The PLT count cut‑off points for the CCRT and RT groups were 150 and 300x109/l, respectively, and the PLT counts were categorized it into three groups: Low (PLT≤150x109/l), moderate (150x109/l300x109/l). To identify independent predictors of overall survival (OS), the Cox proportional hazards model was used to determine local‑regional recurrence‑free survival (LRFS) and distant metastasis‑free survival (DMFS) rates in the CCRT and RT patients. Furthermore, univariate and multivariate analysis indicated that compared with a moderate PLT count, a low PLT count was an independent unfavorable prognostic factor for OS rate in CCRT patients [hazard ratio (HR), 2.024; 95% confidence interval (CI), 1.165‑3.516], and a high PLT count was an independent unfavorable prognostic factor for OS and DMFS rates in CCRT (OS: HR, 1.742; 95% CI, 1.090‑2.786; DFMS: HR, 2.110; 95%CI, 1.084‑4.108) and RT (OS: HR, 1.740; 95%CI, 1.283‑2.362; DMFS: HR, 2.819; 95% CI, 1.766‑4.497) patients. Compared with a low PLT count, a high PLT count was significantly and independently associated with a poor DMFS rate in the RT patients (P=0.025; HR, 2.454; 95% CI, 1.121‑5.372). Therefore, the present study indicates that low and high PLT counts may be useful indicators of survival and distant metastasis in NPC patients who have undergone radiation treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Chen YP, Chen C, Mai ZY, Gao J, Shen LJ, Zhao BC, Chen MK, Chen G, Yan F, Huang TY, Huang TY, et al: Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients. Oncol Lett 9: 1458-1466, 2015.
APA
Chen, Y., Chen, C., Mai, Z., Gao, J., Shen, L., Zhao, B. ... Xia, Y. (2015). Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients. Oncology Letters, 9, 1458-1466. https://doi.org/10.3892/ol.2015.2872
MLA
Chen, Y., Chen, C., Mai, Z., Gao, J., Shen, L., Zhao, B., Chen, M., Chen, G., Yan, F., Huang, T., Xia, Y."Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients". Oncology Letters 9.3 (2015): 1458-1466.
Chicago
Chen, Y., Chen, C., Mai, Z., Gao, J., Shen, L., Zhao, B., Chen, M., Chen, G., Yan, F., Huang, T., Xia, Y."Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients". Oncology Letters 9, no. 3 (2015): 1458-1466. https://doi.org/10.3892/ol.2015.2872
Copy and paste a formatted citation
x
Spandidos Publications style
Chen YP, Chen C, Mai ZY, Gao J, Shen LJ, Zhao BC, Chen MK, Chen G, Yan F, Huang TY, Huang TY, et al: Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients. Oncol Lett 9: 1458-1466, 2015.
APA
Chen, Y., Chen, C., Mai, Z., Gao, J., Shen, L., Zhao, B. ... Xia, Y. (2015). Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients. Oncology Letters, 9, 1458-1466. https://doi.org/10.3892/ol.2015.2872
MLA
Chen, Y., Chen, C., Mai, Z., Gao, J., Shen, L., Zhao, B., Chen, M., Chen, G., Yan, F., Huang, T., Xia, Y."Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients". Oncology Letters 9.3 (2015): 1458-1466.
Chicago
Chen, Y., Chen, C., Mai, Z., Gao, J., Shen, L., Zhao, B., Chen, M., Chen, G., Yan, F., Huang, T., Xia, Y."Pretreatment platelet count as a predictor for survival and distant metastasis in nasopharyngeal carcinoma patients". Oncology Letters 9, no. 3 (2015): 1458-1466. https://doi.org/10.3892/ol.2015.2872
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