Benign pulmonary metastasizing leiomyoma of the uterus: A case report

Ma,Hui; Cao,Jie

doi:10.3892/ol.2015.2878

March-2015 Volume 9 Issue 3

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March-2015 Volume 9 Issue 3

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Case Report

Benign pulmonary metastasizing leiomyoma of the uterus: A case report

Authors:
- Hui Ma
- Jie Cao
View Affiliations / Copyright

Affiliations: Respiratory Department, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
Pages: 1347-1350
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Published online on: January 15, 2015

https://doi.org/10.3892/ol.2015.2878
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Abstract

Pulmonary benign metastasizing leiomyoma (BML), is characterized by multiple pulmonary nodular lesions and is a rare disease. The present study reports the case of a 45‑year‑old asymptomatic woman who underwent an excision of uterine leiomyoma 11 years previously. Chest computed tomography (CT) revealed multiple bilateral pulmonary nodules five months prior to admission, during a regular check‑up. Intravenous levofloxacin (0.5 g/day) was administered for one week, which demonstrated no effect. Positron emission tomography combined with CT (PET/CT) revealed no evident radioactivity concentration. Due to the suspicion of metastasizing leiomyoma, video‑assisted thoracoscopic surgery, with a wedge resection of the right pulmonary lesion, was performed. Post‑operative pathological examination revealed the lesion to be a pulmonary leiomyoma accompanied by local necrosis. Immunohistochemical staining revealed that the lesion was positive for the expression of smooth muscle actin, desmin, estrogen receptor, progesterone receptor and B‑cell lymphoma‑2. Cytokeratin and epithelial membrane antigen were not expressed in the tumor cells. Staining for Ki‑67 revealed expression of Ki‑67 in ~1% of the spindle cells. The overall morphological and immunohistochemical features, accompanied by the remote patient history of primary uterine leiomyoma, supported the diagnosis of pulmonary BML.

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1	Taftaf R, Starnes S, Wang J, et al: Benign metastasizing leiomyoma: A rare type of lung metastases - two case reports and review of the literature. Case Rep Oncol Med. 2014:8428412014.
2	Egberts JH, Schafmayer C, Bauerschlag DO, Jänig U and Tepel J: Benign abdominal and pulmonary metastasizing leiomyoma of the uterus. Arch Gynecol Obstet. 274:319–322. 2006. View Article : Google Scholar : PubMed/NCBI
3	Allen MS: Multiple benign lung tumors. Semin Thorac Cardiovasc Surg. 15:310–314. 2003. View Article : Google Scholar : PubMed/NCBI
4	Yoon G, Kim TJ, Sung CO, et al: Benign metastasizing leiomyoma with multiple lymph node metastasis: a case report. Cancer Res Treat. 43:131–133. 2011. View Article : Google Scholar : PubMed/NCBI
5	Nakanishi S, Nakano K, Hiramoto T, Shimizu M, Nakamura K and Yamane N: So-called benign metastasizing leiomyoma of the lung presenting with bone metastases. Nihon Kokyuki Gakkai Zasshi. 37:146–150. 1999.(In Japanese). PubMed/NCBI
6	Tietze L, Günther K, Hörbe A, et al: Benign metastasizing leiomyoma: a cytogenetically balanced but clonal disease. Hum Pathol. 31:126–128. 2000. View Article : Google Scholar : PubMed/NCBI
7	Maredia R, Snyder BJ, Harvey LA and Schwartz AM: Benign metastasizing leiomyoma in the lung. Radiographics. 18:779–782. 1998. View Article : Google Scholar : PubMed/NCBI
8	Patton KT, Cheng L, Papavero V, et al: Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. Mod Pathol. 19:130–140. 2006. View Article : Google Scholar
9	Schneider T, Kugler C, Kayser K and Dienemann H: Benignes, pulmonal metastasierendes Leiomyom des Uterus. Der Chirurg. 72:308–311. 2001.(In German). View Article : Google Scholar
10	Ki EY, Hwang SJ, Lee KH, Park JS and Hur SY: Benign metastasizing leiomyoma of the lung. World J Surg Oncol. 11:2792013. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Benign pulmonary metastasizing leiomyoma of the uterus: A case report

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Abstract

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