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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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March-2015 Volume 9 Issue 3

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Case Report

Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature

  • Authors:
    • Fei Yan
    • Yanli Ma
    • Jianhai Sun
    • Pengcheng Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Zhongshan Hospital of Hubei Province, Wuhan, Hubei 430000, P.R. China, Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 1343-1346
    |
    Published online on: January 16, 2015
       https://doi.org/10.3892/ol.2015.2882
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Abstract

Reactive nodular fibrous pseudotumor (RNFP) is a tumor‑like lesion that is characterized by reactive fibroblast/myofibroblast proliferation within collagenic hyalinized stroma, due to its association with injury or inflammation. The current study describes the case of a 60‑year‑old female with a history of abdominal surgery and abdominal pain. Upon laparoscopy, multiple nodules attached to the outer layer of the colon and mesentery were identified, and therefore, complete surgical excision was performed. Macroscopically, the nodules were well‑circumscribed, firm, tan‑white in color and ranged in size between 2.0‑10.0 cm at the greatest dimension. Microscopically, the nodules were composed of spindle and stellate cells in a dense collagenic hyalinized background with sparse lymphocytic infiltration. Immunohistochemical analysis demonstrated positive staining for vimentin, smooth muscle actin and cluster of differentiation (CD) 117, and focally‑positive keratin staining with AE1/AE3; however, no staining was observed for gastrointestinal stromal tumor 1, CD34, S‑100, anaplastic lymphoma kinase or β‑catenin. Therefore, it was proposed that the lesion may be most accurately described as an RNFP. The current study reports a rare case of RNFP, emphasizing its histopathological features and differential diagnoses to promote an improved and broader understanding of this poorly understood condition.
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1 

Yantiss RK, Nielsen GP, Lauwers GY and Rosenberg AE: Reactive nodular fibrous pseudotumor of the gastrointestinal tract and mesentery: a clinicopathologic study of five cases. Am J Surg Pathol. 27:532–540. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Saglam EA, Usubütün A, Kart C, Ayhan A and Küçükali T: Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature. Virchows Arch. 447:879–882. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Yin SS, Zhang L, Cziffer-Paul A, Divino CM and Chin E: Reactive nodular fibrous pseudotumor presenting as a small bowel obstruction. Am Surg. 77:790–791. 2011.PubMed/NCBI

4 

Daum O, Vanecek T, Sima R, et al: Reactive nodular fibrous pseudotumors of the gastrointestinal tract: report of 8 cases. Int J Surg Pathol. 12:365–374. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Barak S, Wang Z and Miettinen M: Immunoreactivity for calretinin and keratins in desmoid fibromatosis and other myofibroblastic tumors: a diagnostic pitfall. Am J Surg Pathol. 36:1404–1409. 2012. View Article : Google Scholar : PubMed/NCBI

6 

McAteer J, Huaco JC, Deutsch GH and Gow KW: Torsed reactive nodular fibrous pseudotumor in an adolescent: case report and review of the literature. J Pediatr Surg. 47:795–798. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Gauchotte G, Bressenot A, Serradori T, Boissel P, Plenat F and Montagne K: Reactive nodular fibrous pseudotumor: a first report of gastric localization and clinicopathologic review. Gastroenterol Clin Biol. 33:1076–1081. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Carruthers MN, Stone JH and Khosroshahi A: The latest on IgG4-RD: a rapidly emerging disease. Curr Opin Rheumatol. 24:60–69. 2012. View Article : Google Scholar

9 

Chetty R, Serra S, Gauchotte G, Märkl B and Agaimy A: Sclerosing nodular lesions of the gastrointestinal tract containing large numbers of IgG4 plasma cells. Pathology. 43:31–35. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Liu FY, Qi JP, Xu FL and Wu AP: Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor. World J Gastroenterol. 12:4161–4165. 2006.PubMed/NCBI

11 

Novelli M, Rossi S, Rodriguez-Justo M, et al: DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 57:259–270. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Lee CH, Liang CW and Espinosa I: The utility of discovered on gastrointestinal stromal tumor 1 (DOG1) antibody in surgical pathology - the GIST of it. Adv Anat Pathol. 17:222–232. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Espinosa I, Lee CH, Kim MK, et al: A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol. 32:210–218. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Hill KA, Gonzalez-Crussi F and Chou PM: Calcifying fibrous pseudotumor versus inflammatory myofibroblastic tumor: a histological and immunohistochemical comparison. Mod Pathol. 14:784–790. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Fetsch JF, Montgomery EA and Meis JM: Calcifying fibrous pseudotumor. Am J Surg Pathol. 17:502–508. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Coffin CM, Watterson J, Priest JR and Dehner LP: Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 19:859–872. 1995. View Article : Google Scholar : PubMed/NCBI

17 

Shatzel J, Wooten K, Ankola A, Cheney RT, Morrison CD and Skitzki JJ: Inflammatory myofibroblastic tumor of the mesentery: a clinical dilemma. Int J Clin Oncol. 17:380–384. 2012. View Article : Google Scholar

18 

Cook JR, Dehner LP, Collins MH, et al: Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study. Am J Surg Pathol. 25:1364–1371. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Ferenc T, Wronski JW, Kopczyński J, et al: Analysis of APC, alpha-, beta-catenins, and N-cadherin protein expression in aggressive fibromatosis (desmoid tumor). Pathol Res Pract. 205:311–324. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Montgomery EA and Meis JM: Nodular fasciitis. Its morphologic spectrum and immunohistochemical profile. Am J Surg Pathol. 15:942–948. 1991. View Article : Google Scholar : PubMed/NCBI

21 

Montgomery E, Torbenson MS, Kaushal M, Fisher C and Abraham SC: Beta-catenin immunohistochemistry separates mesenteric fibromatosis from gastrointestinal stromal tumor and sclerosing mesenteritis. Am J Surg Pathol. 26:1296–1301. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yan F, Ma Y, Sun J and Zhu P: Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature. Oncol Lett 9: 1343-1346, 2015.
APA
Yan, F., Ma, Y., Sun, J., & Zhu, P. (2015). Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature. Oncology Letters, 9, 1343-1346. https://doi.org/10.3892/ol.2015.2882
MLA
Yan, F., Ma, Y., Sun, J., Zhu, P."Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature". Oncology Letters 9.3 (2015): 1343-1346.
Chicago
Yan, F., Ma, Y., Sun, J., Zhu, P."Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature". Oncology Letters 9, no. 3 (2015): 1343-1346. https://doi.org/10.3892/ol.2015.2882
Copy and paste a formatted citation
x
Spandidos Publications style
Yan F, Ma Y, Sun J and Zhu P: Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature. Oncol Lett 9: 1343-1346, 2015.
APA
Yan, F., Ma, Y., Sun, J., & Zhu, P. (2015). Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature. Oncology Letters, 9, 1343-1346. https://doi.org/10.3892/ol.2015.2882
MLA
Yan, F., Ma, Y., Sun, J., Zhu, P."Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature". Oncology Letters 9.3 (2015): 1343-1346.
Chicago
Yan, F., Ma, Y., Sun, J., Zhu, P."Reactive nodular fibrous pseudotumor involving the gastrointestinal tract and mesentery: A case report and review of the literature". Oncology Letters 9, no. 3 (2015): 1343-1346. https://doi.org/10.3892/ol.2015.2882
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