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Review Open Access

Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review)

  • Authors:
    • José Veríssimo Fernandes
    • Thales Allyrio Araújo de Medeiros Fernandes
    • Jenner Chrystian Veríssimo de Azevedo
    • Ricardo Ney Oliveira Cobucci
    • Maria Goretti Freire de Carvalho
    • Vania Sousa Andrade
    • Josélio Maria Galvão de Araújo
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology and Parasitology, Federal University of Rio Grande do Norte, Natal 59072‑970, Brazil, Department of Biomedical Sciences, University of Rio Grande do Norte State, Mossoró 59607‑360, Brazil, Department of Pediatrics, University Hospital Onofre Lopes, Federal University of Rio Grande do Norte, Natal 59072‑970, Brazil, Januário Cicco Maternity School, Federal University of Rio Grande do Norte, Natal 59072‑970, Brazil, Department of Pathology, Potiguar University, Natal 59020-500, Brazil
    Copyright: © Fernandes et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1015-1026
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    Published online on: January 16, 2015
       https://doi.org/10.3892/ol.2015.2884
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Abstract

Inflammation is a defense strategy against invading agents and harmful molecules that is activated immediately following a stimulus, and involves the release of cytokines and chemokines, which activate the innate immune response. These mediators act together to increase blood flow and vascular permeability, facilitating recruitment of effector cells to the site of injury. Following resolution of the injury and removal of the stimulus, inflammation is disabled, but if the stimulus persists, inflammation becomes chronic and is strongly associated with cancer. This is likely to be due to the fact that the inflammation leads to a wound that does not heal, requiring a constant renewal of cells, which increases the risk of neoplastic transformation. Debris from phagocytosis, including the reactive species of oxygen and nitrogen that cause damage to DNA already damaged by the leukotrienes and prostaglandins, has an impact on inflammation and various carcinogenic routes. There is an association between chronic inflammation, persistent infection and cancer, where oncogenic action is mediated by autocrine and paracrine signals, causing changes in somatic cells under the influence of the microbial genome or of epigenetic factors. Among the infectious agents associated with cancer, certain genotypes of human papillomavirus (HPV) stand out. HPV is responsible for virtually all cases of cervical cancer and a lower proportion of cancers of the vagina, vulva, anus, penis and a number of extragenital cancers. In the present review, recent advances in the mechanisms involved in the inflammatory response are presented with their participation in the process of carcinogenesis, emphasizing the role of chronic inflammation in the development of HPV‑induced cervical cancer.
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1 

Ashley NT, Weil ZM and Nelson RJ: Inflammation: mechanisms, costs, and natural variation. Ann Rev Ecol Evol Syst. 43:385–406. 2012. View Article : Google Scholar

2 

Medzhitov R: Origin and physiological roles of inflammation. Nature. 454:428–435. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Graham BS: Biological challenges and technological opportunities for respiratory syncytial virus vaccine development. Immunol Rev. 239:149–166. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Martinon F, Mayor A and Tschopp J: The inflammasomes: guardians of the body. Annu Rev Immunol. 27:229–265. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Nathan C: Points of control in inflammation. Nature. 420:846–852. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Adefuye A and Sales K: Regulation of inflammatory pathways in cancer and infectious disease of the cervix. Scientifica (Cairo). 2012:5481502012.

7 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Schottenfeld D and Beebe-Dimmer JL: Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions. Ann Rev Public Health. 26:37–60. 2005. View Article : Google Scholar

9 

Akagi K, Li J, Broutian TR, Padilla-Nash H, et al: Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res. 24:185–199. 2014. View Article : Google Scholar :

10 

Trottier H and Franco EL: The epidemiology of genital human papillomavirus infection. Vaccine. 24(Suppl 1): S1–S15. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Muñoz N, Castellsagué X, de González AB and Gissmann L: Chapter 1: HPV in the etiology of human cancer. Vaccine. 24(Suppl 3): S1–S10. 2006. View Article : Google Scholar

12 

Mazibrada J, Rittà M, Mondini M, et al: Interaction between inflammation and angiogenesis during different stages of cervical carcinogenesis. Gynecol Oncol. 108:112–120. 2008. View Article : Google Scholar

13 

Paghini BC, Abdalla DR, Barcelos AC, et al: Local cytokine profiles of patients with cervical intraepithelial and invasive neoplasia. Hum Immunol. 73:920–926. 2012. View Article : Google Scholar

14 

Graham CS, Wells A, Liu T, et al: Antigen-specific immune responses and liver histology in HIV and hepatitis C coinfection. AIDS. 19:767–773. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Tang T, Wong HK, Gu W, et al: MicroRNA-182 plays an onco-miRNA role in cervical cancer. Gynecol Oncol. 129:199–208. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Viviani B, Bartesaghi S, Gardoni F, et al: Interleukin-1beta enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J Neurosci. 23:8692–8700. 2003.PubMed/NCBI

17 

Pasparakis M: Regulation of tissue homeostasis by NF-kappaB signaling: implications for inflammatory diseases. Nat Rev Immunol. 9:778–788. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Lou JL, Maeda S, Hsu LC, et al: Inhibition of NF-kappaB in cancer cells converts inflammation-induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell. 6:297–305. 2004. View Article : Google Scholar

19 

Hussain SP, Hofseth LJ and Harris CC: Radical causes of cancer. Nat Rev Cancer. 3:276–285. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Chen WL and Konkel JE: TGF-beta and ‘adaptive’ Foxp3(+) regulatory T cells. J Mol Cell Biol. 2:30–36. 2010. View Article : Google Scholar :

21 

Derynck R, Akhurst RJ and Balmain A: TGF-beta signaling in tumor suppression and cancer progression. Nat Genet. 29:117–129. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Ishihara K and Hirano T: Il-6 autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13:357–368. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Jenkins BJ, Roberts AW, Greenhill CJ, et al: Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis. Blood. 109:2380–2388. 2007. View Article : Google Scholar

24 

Vicari AP and Trinchieri G: Interleukin-10 in viral diseases and cancer: exiting the labyrinth? Immunol Rev. 202:223–236. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Mocellin S, Marincola FM and Young HA: Interleukin-10 and the immune response against cancer: a counterpoint. J Leukoc Biol. 78:1043–1051. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Sadler AJ and Williams BR: Interferon-inducible antiviral effectors. Nature Rev Immunol. 8:559–568. 2008. View Article : Google Scholar

27 

González-Navajas JM, Lee J, David M and Raz E: Immunomodulatory functions of type I interferons. Nat Rev Immunol. 12:125–135. 2012.PubMed/NCBI

28 

Guarda G, Braun M, Staehli F, et al: Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity. 34:213–223. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Schroder K, Hertzog PJ, Ravasi T and Hume DA: Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol. 75:163–189. 2004. View Article : Google Scholar

30 

Schoenborn JR and Wilson CB: Regulation of Interferon-gamma during innate and adaptive immune responses. Adv Immunol. 96:41–101. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Ruddy MJ, Wong GC, Liu XK, et al: Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members. J Biol Chem. 279:2559–2567. 2004. View Article : Google Scholar

32 

Zhang Y, Ma D, Zhang Y, et al: The imbalance of Th17/Treg in patients with uterine cervical cancer. Clin Chim Acta. 412:894–900. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Chen Z, Ding J, Pang N, et al: The Th17/Treg balance and the expression of related cytokines in Uygur cervical cancer patients. Diagn Pathol. 8:612013. View Article : Google Scholar : PubMed/NCBI

34 

Cho ML, Kang JW, Moon YM, et al: STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J Immunol. 176:5652–5661. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Hao JS and Shan BE: Immune enhancement and anti-tumour activity of IL-23. Cancer Immunol Immunother. 55:1426–1431. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Biet F, Locht C and Kremer L: Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens. J Mol Med (Berl). 80:147–162. 2002. View Article : Google Scholar

37 

Nakanishi K: Regulation of Th1 and Th2 immune responses by IL-18. Kekkaku. 77:87–93. 2002.(Japanese). PubMed/NCBI

38 

Reddy P and Ferrara JL: Role of interleukin-18 in acute graft-vs-host disease. J Lab Clin Med. 141:365–371. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Medzhitov R: Origin and physiological roles of inflammation. Nature. 454:428–435. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Serhan CN and Savill J: Resolution of inflammation: the beginning programs the end. Nat Immunol. 6:1191–1197. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Akira S, Uematsu S and Takeuchi O: Pathogen recognition and innate immunity. Cell. 124:783–801. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Mogensen TH: Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev. 22:240–273. 2009. View Article : Google Scholar : PubMed/NCBI

43 

Roach JC, Glusman G, Rowen L, et al: The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci USA. 102:9577–9582. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Proell M, Riedl SJ, Fritz JH, et al: The Nod-like receptor (NLR) family: a tale of similarities and differences. PLoS One. 3:e21192008. View Article : Google Scholar : PubMed/NCBI

45 

Friedman R and Hughes AL: Molecular evolution of the NF-kappaB signaling system. Immunogenetics. 53:964–974. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Ahmed AU: An overview of inflammation: mechanism and consequences. Front Biol. 6:274–281. 2011.

47 

Welsh RM, Bahl K, Marshall HD and Urban SL: Type 1 interferons and antiviral CD8 T-Cell responses. PLoS Pathog. 8:e10023522012. View Article : Google Scholar : PubMed/NCBI

48 

Sica A and Bronte V: Altered macrophage differentiation and immune dysfunction in tumor development. J Clin Invest. 117:1155–1166. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Liu CY, Xu JY, Shi XY, et al: M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway. Lab Invest. 93:844–854. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Lin WW and Karin M: A cytokine-mediated link between innate immunity, inflammation and cancer. J Clin Invest. 117:1175–1183. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Sieve AN, Meeks KD, Lee S and Berg RE: A novel immunoregulatory function for IL-23: inhibition of IL-12-dependent IFN-γ production. Eur J Immunol. 40:2236–2247. 2010. View Article : Google Scholar : PubMed/NCBI

52 

Rubtsov YP, Rasmussen JP, Chi EY, et al: Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 28:546–558. 2008. View Article : Google Scholar : PubMed/NCBI

53 

Ouyang W, Kolls JK and Zheng Y: The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 28:454–467. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Koch MA, Trucker-Heard G, Perduc NR, et al: The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol. 10:595–602. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Anthony MN, Gardner L, Marks G, et al: Factors associated with use of HIV primary care among persons recently diagnosed with HIV: examination of variables from the behavioural model of health-care utilization. AIDS Care. 19:195–202. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Anthony RM, Rutitzky LI, Urban JF Jr, Stadecker MJ and Gause WC: Protective immune mechanisms in helminth infection. Nat Rev Immunol. 7:975–987. 2007. View Article : Google Scholar : PubMed/NCBI

57 

Graham AL: When T-helper cells don’t help: immunopathology during concomitant infection. Q Rev Biol. 77:409–434. 2002. View Article : Google Scholar

58 

Suvas S, Azkur AK, Kim BS, et al: CD4+CD25+ regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol. 172:4123–4132. 2004. View Article : Google Scholar : PubMed/NCBI

59 

Belkaid Y and Tarbell K: Regulatory T Cells in the Control of host-microorganism interactions. Ann Rev Immunol. 27:551–589. 2009. View Article : Google Scholar

60 

Korn T, Bettelli E, Oukka M and Kuchroo VK: IL-17 and Th17 cells. Ann Rev Immunol. 27:485–517. 2009. View Article : Google Scholar

61 

Jabbour HN, Sales KJ, Catalano RD and Norman JE: Inflammatory pathways in female reproductive health and disease. Reproduction. 138:903–919. 2009. View Article : Google Scholar : PubMed/NCBI

62 

Maeda K, Yoshida K, Ichimiya I and Suzuki M: Dexamethasone inhibits tumor necrosis factor-alpha-induced cytokine secretion from spiral ligament fibrocytes. Hear Res. 202:154–160. 2005. View Article : Google Scholar : PubMed/NCBI

63 

Sakurai F, Nakamura S, Akitomo K, Shibata H, et al: Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates. Mol Ther. 16:726–733. 2008. View Article : Google Scholar : PubMed/NCBI

64 

Mantovani A, Allavena P, Sica A and Balkwill F: Cancer-related inflammation. Nature. 454:436–444. 2008. View Article : Google Scholar : PubMed/NCBI

65 

Karin M and Greten FR: NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 5:749–759. 2005. View Article : Google Scholar : PubMed/NCBI

66 

Karin M: Nuclear factor-kappaB in cancer development and progression. Nature. 441:431–436. 2006. View Article : Google Scholar : PubMed/NCBI

67 

Karin M: NF-kappaB and cancer: mechanisms and targets. Mol Carcinog. 45:355–361. 2006. View Article : Google Scholar : PubMed/NCBI

68 

Karin M, Cao Y, Greten FR and Li ZW: NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer. 2:301–310. 2002. View Article : Google Scholar : PubMed/NCBI

69 

Lou L, Li DQ, Corrales RM and Pflugfelder SC: Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. 31:186–193. 2005. View Article : Google Scholar

70 

Parkin DM and Bray F: Chapter 2: The burden of HPV-related cancers. Vaccine. 24(Suppl 3): S11–S25. 2006. View Article : Google Scholar

71 

Shukla S, Bharti AC, Mahata S, et al: Infection of human papillomavirus in cancers of different human organ sites. Indian J Med Res. 130:222–233. 2009.PubMed/NCBI

72 

Moody CA and Laimins LA: Human papillomavirus oncoproteins: pathways to transformation. Nat Rev Cancer. 10:550–560. 2010. View Article : Google Scholar : PubMed/NCBI

73 

Fernandes JV, Araújo JMG and Fernandes TAAM: Biology and natural history of human papillomavirus infection. Open Access J Clin Trials. 5:1–12. 2013. View Article : Google Scholar

74 

Hernádi Z, Gazdag L, Szoke K, Sápy T, Krasznai ZT and Kónya J: Duration of HPV-associated risk for high-grade cervical intraepithelial neoplasia. Eur J Obstet Gynecol Reprod Biol. 125:114–119. 2006. View Article : Google Scholar

75 

Fernandes JV, Fernandes TAAM and de Araújo JMG: Human papillomavirus infection in adolescents. Handbook on Human Papillomavirus: Prevalence, Detection & Management. Smith HB: Nova Science Publishers; New York, NY: pp. 181–212. 2013

76 

Jemal A, Bray F, Center MM, et al: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

77 

Stanley M: Immune responses to human papillomavirus. Vaccine. 24(Suppl 1): S16–S22. 2006. View Article : Google Scholar

78 

Smith JS, Herrero R, Bosetti C, et al: Herpes simplex virus-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer. J Natl Cancer Inst. 94:1604–1613. 2002. View Article : Google Scholar : PubMed/NCBI

79 

Smith JS, Muñoz N, Herrero R, et al: Evidence for Chlamydia trachomatis as a human papillomavirus cofactor in the etiology of invasive cervical cancer in Brazil and the Philippines. J Infect Dis. 185:324–331. 2002. View Article : Google Scholar : PubMed/NCBI

80 

de Abreu AL, Nogara PR, Souza RP, et al: Molecular detection of HPV and Chlamydia trachomatis infections in Brazilian women with abnormal cervical cytology. Am J Trop Med Hyg. 87:1149–1151. 2012. View Article : Google Scholar : PubMed/NCBI

81 

Scott M, Stites DP and Mosciki AB: Th1 cytokine patterns in cervical human papillomavirus infection. Clin Diagn Lab Immunol. 6:751–755. 1999.PubMed/NCBI

82 

Adefuye A and Sales K: Regulation of inflammatory pathways in cancer and infectious disease of the cervix. Scientifica (Cairo). 2012:5481502012.

83 

Ambros V and Chen X: The regulation of genes and genomes by small RNAs. Development. 134:1635–1641. 2007. View Article : Google Scholar : PubMed/NCBI

84 

Niwa R and Slack FJ: The evolution of animal microRNA function. Curr Opin Genet Dev. 17:145–150. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Croce CM: Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 10:704–714. 2009. View Article : Google Scholar : PubMed/NCBI

86 

Tili E, Michaillle JJ and Croce CM: MicroRNAs play a central role in molecular dysfunctions linking inflammation with cancer. Immunol Rev. 253:167–184. 2013. View Article : Google Scholar : PubMed/NCBI

87 

Trotta R, Chen L, Ciarlariello D, et al: miR-155 regulates IFN-γ production in natural killer cells. Blood. 119:3478–3485. 2012. View Article : Google Scholar : PubMed/NCBI

88 

Schetter AJ, Okayama H and Harris CC: The role of microRNAs in colorectal cancer. Cancer J. 18:244–252. 2012. View Article : Google Scholar : PubMed/NCBI

89 

de Visser KE, Korets LV and Coussens LM: De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell. 7:411–423. 2005. View Article : Google Scholar : PubMed/NCBI

90 

Viau M and Zouali M: B-lymphocytes, innate immunity, and autoimmunity. Clin Immunol. 114:17–26. 2005. View Article : Google Scholar

91 

Balkwill F, Charies KA and Mantovani A: Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell. 7:211–217. 2005. View Article : Google Scholar : PubMed/NCBI

92 

Hawes SE and Kiviat NB: Are genital infections and inflammation cofactors in the pathogenesis of invasive cervical cancer? J Natl Cancer Inst. 94:1592–1593. 2002. View Article : Google Scholar : PubMed/NCBI

93 

Schwebke JR and Zajackowski ME: Effect of concurrent lower genital tract infections on cervical cancer screening. Genitourin Med. 73:383–386. 1997.

94 

Castle PE, Hillier SL, Rabe LK, et al: An association of cervical inflammation with high-grade cervical neoplasia in women infected with oncogenic human papillomavirus (HPV). Cancer Epidemiol Biomarkers Prev. 10:1021–1027. 2001.PubMed/NCBI

95 

Yang YC, Chang CL, Huang YW and Wang DY: Possible cofactor in cervical carcinogenesis: proliferation index of the transformation zone in cervicitis. Chang Gung Med J. 24:615–620. 2001.

96 

Hammes LS, Tekmal RR, Naud P, et al: Macrophages, inflammation and risk of cervical intraepithelial neoplasia (CIN) progression - clinicopathological correlation. Gynecol Oncol. 105:157–165. 2007. View Article : Google Scholar : PubMed/NCBI

97 

Kovacic MB, Katki HA, Kreimer AR and Sherman ME: Epidemiologic analysis of histologic cervical inflammation: relationship to human papillomavirus infections. Human Pathol. 39:1088–1095. 2008. View Article : Google Scholar

98 

Sharkey DJ, Tremellen KP, Jasper MJ, et al: Seminal fluid Induces leukocyte recruitment and cytokine and chemokine mRNA expression in the human cervix after coitus. J Immunol. 188:2445–2454. 2012. View Article : Google Scholar : PubMed/NCBI

99 

Manhart LS and Koutsky LZ: Do condoms prevent genital HPV infection, external genital warts, or cervical neoplasia? A meta-analysis. Sex Transm Dis. 29:725–735. 2002. View Article : Google Scholar : PubMed/NCBI

100 

Sales KJ and Jabbour HN: Cyclooxygenase enzymes and prostaglandins in reproductive tract physiology and pathology. Prostaglandins Other Lipid Mediat. 71:97–117. 2003. View Article : Google Scholar : PubMed/NCBI

101 

Silva J: Cerqueira F and Medeiros R: Chlamydia trachomatis infection: implications for HPV status and cervical cancer. Arch Gynecol Obstet. 289:715–23. 2014. View Article : Google Scholar

102 

Niebler M, Quian X, Höfler D, et al: Post-translational control of IL-1β via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53. PLOS Pathog. 9:e10035362013. View Article : Google Scholar

103 

Kemp TJ, Hildesheim A, Garcia-Piñeres A, et al: Elevated systemic levels of inflammatory cytokines in older women with persistent cervical HPV infection. Cancer Epidemiol Biomarkers Prev. 19:1954–1959. 2010. View Article : Google Scholar : PubMed/NCBI

104 

Kaul R and Hirbod T: Editorial: Genital epithelial cells: foot soldiers or fashion leaders? J Leuk Biol. 88:427–429. 2010. View Article : Google Scholar

105 

Stanley M: Pathology and epidemiology of HPV infection in females. Gynecol Oncol. 117(Suppl 2): S5–S10. 2010. View Article : Google Scholar

106 

Karim R, Tummers B, Meyers C, et al: Human papillomavirus (HPV) upregulates t6he cellular deubiquitinase UCHL1 to suppress the keratinocyte’s innate immune response. PLOS Pathog. 9:e10033842013. View Article : Google Scholar

107 

Senba M and Mori N: Mechanisms of virus immune evasion lead to development from chronic inflammation to cancer formation associated with human papillomavirus infection. Oncol Rev. 6:135–144. 2012. View Article : Google Scholar

108 

Senba M, Buziba N, Mori N, et al: Human papillomavirus infection induces NF-κB activation in cervical cancer: a comparison with penile cancer. Oncol Lett. 2:65–68. 2011.PubMed/NCBI

109 

James MA, Lee JH and Klingelhutz AJ: Human papillomavirus type 16 E6 activates NF-kappaB, induces cIAP-2 expression, and protects against apoptosis in a PDZ binding motif-dependent manner. J Virol. 80:5301–5307. 2006. View Article : Google Scholar : PubMed/NCBI

110 

Scott ME, Shvetsov YB, Thompson PJ, et al: Cervical cytokines and clearance of incident human papillomavirus infection: Hawaii HPV cohort study. Int J Cancer. 133:1187–1196. 2013. View Article : Google Scholar : PubMed/NCBI

111 

Broccardo E, Lepique AP and Villa LL: The role of inflammation in HPV carcinogenesis. Carcinogenesis. 31:1905–1912. 2010. View Article : Google Scholar

112 

Balkwill F: Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev. 13:135–41. 2002. View Article : Google Scholar : PubMed/NCBI

113 

Stanley MA, Pett MR and Coleman N: HPV: from infection to cancer. Bioch Soc Trans. 35:1456–1460. 2007. View Article : Google Scholar

114 

Tindle RW: Immune evasion in human papillomavirus-associated cervical cancer. Nature Rev Cancer. 2:59–65. 2002. View Article : Google Scholar

115 

zur Hausen H: Papillomaviruses in the causation of human cancers - a brief historical account. Virology. 384:260–265. 2009. View Article : Google Scholar : PubMed/NCBI

116 

Oh JM, Kim SH, Lee YI, et al: Human papillomavirus E5 protein induces expression of the EP4 subtype of prostaglandin E2 receptor in cyclic AMP response element-dependent pathways in cervical cancer cells. Carcinogenesis. 30:144–149. 2009.

117 

Bodily J and Laimins LA: Persistence of human papillomavirus infection: keys to malignant progression. Trends Microbiol. 19:33–39. 2011. View Article : Google Scholar :

118 

Trinchieri G: Innate inflammation and cancer: is it time for cancer prevention? F1000 Med Rep. 3:112011. View Article : Google Scholar : PubMed/NCBI

119 

Sales KJ, Katz AA, Howard B, et al: Cyclooxygenase-1 is up-regulated in cervical carcinomas: autocrine/paracrine regulation of cyclooxygenase-2, prostaglandin e receptors, and angiogenic factors by cyclooxygenase-1. Cancer Res. 62:424–432. 2002.PubMed/NCBI

120 

Santin AD, Zhan F, Bignotti E, et al: Gene expression profiles of primary HPV16- and HPV18-infected early stage cervical cancers and normal cervical epithelium: identification of novel candidate molecular markers for cervical cancer diagnosis and therapy. Virol. 331:269–291. 2005. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Fernandes JV, Fernandes TA, de Azevedo JC, Cobucci RN, de Carvalho MG, Andrade VS and de Araújo JM: Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review). Oncol Lett 9: 1015-1026, 2015.
APA
Fernandes, J.V., Fernandes, T.A., de Azevedo, J.C., Cobucci, R.N., de Carvalho, M.G., Andrade, V.S., & de Araújo, J.M. (2015). Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review). Oncology Letters, 9, 1015-1026. https://doi.org/10.3892/ol.2015.2884
MLA
Fernandes, J. V., Fernandes, T. A., de Azevedo, J. C., Cobucci, R. N., de Carvalho, M. G., Andrade, V. S., de Araújo, J. M."Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review)". Oncology Letters 9.3 (2015): 1015-1026.
Chicago
Fernandes, J. V., Fernandes, T. A., de Azevedo, J. C., Cobucci, R. N., de Carvalho, M. G., Andrade, V. S., de Araújo, J. M."Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review)". Oncology Letters 9, no. 3 (2015): 1015-1026. https://doi.org/10.3892/ol.2015.2884
Copy and paste a formatted citation
x
Spandidos Publications style
Fernandes JV, Fernandes TA, de Azevedo JC, Cobucci RN, de Carvalho MG, Andrade VS and de Araújo JM: Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review). Oncol Lett 9: 1015-1026, 2015.
APA
Fernandes, J.V., Fernandes, T.A., de Azevedo, J.C., Cobucci, R.N., de Carvalho, M.G., Andrade, V.S., & de Araújo, J.M. (2015). Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review). Oncology Letters, 9, 1015-1026. https://doi.org/10.3892/ol.2015.2884
MLA
Fernandes, J. V., Fernandes, T. A., de Azevedo, J. C., Cobucci, R. N., de Carvalho, M. G., Andrade, V. S., de Araújo, J. M."Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review)". Oncology Letters 9.3 (2015): 1015-1026.
Chicago
Fernandes, J. V., Fernandes, T. A., de Azevedo, J. C., Cobucci, R. N., de Carvalho, M. G., Andrade, V. S., de Araújo, J. M."Link between chronic inflammation and human papillomavirus-induced carcinogenesis (Review)". Oncology Letters 9, no. 3 (2015): 1015-1026. https://doi.org/10.3892/ol.2015.2884
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