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Article

Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer

  • Authors:
    • Benjamín Gómez-Díaz
    • María de la Luz Ayala-Madrigal
    • Melva Gutiérrez-Angulo
    • Aura Erazo Valle-Solis
    • Luis Miguel Linares-González
    • Roberto González-Guzmán
    • David Cruz-Guillén
    • Ana Lilia Cedeño-Garcidueñas
    • Patricia Canto
    • Luz Berenice López-Hernández
  • View Affiliations / Copyright

    Affiliations: National Institute of Rehabilitation, México City, México, Institute of Human Genetics, UCHS, University of Guadalajara, Wet Saw, Guadalajara, Jalisco, México, Department of Clinics, UCALTOS, University of Guadalajara, Tepatitlán, Jalisco, México, National Medical Centre '20th November,' Institute for Social Security of State Workers, México City, México, Obesity Research Unit, Faculty of Medicine, National Autonomous University of Mexico, México City, México
  • Pages: 1657-1661
    |
    Published online on: January 26, 2015
       https://doi.org/10.3892/ol.2015.2894
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Abstract

The Asn118Asn (rs11615) variant in the ERCC1 gene, and the Lys751Gln (rs13181) and Asp312Asn (rs1799793) variants in the ERCC2 gene have been associated with the development of varied types of cancer. The aim of the present study was to test for any association between the ERCC1 and ERCC2 gene variants and three different types of cancer in Mexican‑mestizo patients. Patients and their respective controls were formed into three groups: The osteosarcoma group, with 28 patients and 97 controls; the colorectal group, with 108 patients and 119 controls; and the breast cancer group, with 71 patients and 74 controls. Genotyping was performed using TaqMan probes and quantitative polymerase chain reaction. Allele and genotype frequencies were compared using a χ2 test. Only one SNP (rs1799793) was found to be associated with breast cancer. This is the first study analyzing the SNPs in ERCC1 and ERCC2 genes and the susceptibility to cancer in Mexican‑mestizo patients with osteosarcoma, and colorectal and breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Gómez-Díaz B, de la Luz Ayala-Madrigal M, Gutiérrez-Angulo M, Valle-Solis AE, Linares-González LM, González-Guzmán R, Cruz-Guillén D, Cedeño-Garcidueñas AL, Canto P, López-Hernández LB, López-Hernández LB, et al: Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer. Oncol Lett 9: 1657-1661, 2015.
APA
Gómez-Díaz, B., de la Luz Ayala-Madrigal, M., Gutiérrez-Angulo, M., Valle-Solis, A.E., Linares-González, L.M., González-Guzmán, R. ... López-Hernández, L.B. (2015). Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer. Oncology Letters, 9, 1657-1661. https://doi.org/10.3892/ol.2015.2894
MLA
Gómez-Díaz, B., de la Luz Ayala-Madrigal, M., Gutiérrez-Angulo, M., Valle-Solis, A. E., Linares-González, L. M., González-Guzmán, R., Cruz-Guillén, D., Cedeño-Garcidueñas, A. L., Canto, P., López-Hernández, L. B."Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer". Oncology Letters 9.4 (2015): 1657-1661.
Chicago
Gómez-Díaz, B., de la Luz Ayala-Madrigal, M., Gutiérrez-Angulo, M., Valle-Solis, A. E., Linares-González, L. M., González-Guzmán, R., Cruz-Guillén, D., Cedeño-Garcidueñas, A. L., Canto, P., López-Hernández, L. B."Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer". Oncology Letters 9, no. 4 (2015): 1657-1661. https://doi.org/10.3892/ol.2015.2894
Copy and paste a formatted citation
x
Spandidos Publications style
Gómez-Díaz B, de la Luz Ayala-Madrigal M, Gutiérrez-Angulo M, Valle-Solis AE, Linares-González LM, González-Guzmán R, Cruz-Guillén D, Cedeño-Garcidueñas AL, Canto P, López-Hernández LB, López-Hernández LB, et al: Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer. Oncol Lett 9: 1657-1661, 2015.
APA
Gómez-Díaz, B., de la Luz Ayala-Madrigal, M., Gutiérrez-Angulo, M., Valle-Solis, A.E., Linares-González, L.M., González-Guzmán, R. ... López-Hernández, L.B. (2015). Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer. Oncology Letters, 9, 1657-1661. https://doi.org/10.3892/ol.2015.2894
MLA
Gómez-Díaz, B., de la Luz Ayala-Madrigal, M., Gutiérrez-Angulo, M., Valle-Solis, A. E., Linares-González, L. M., González-Guzmán, R., Cruz-Guillén, D., Cedeño-Garcidueñas, A. L., Canto, P., López-Hernández, L. B."Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer". Oncology Letters 9.4 (2015): 1657-1661.
Chicago
Gómez-Díaz, B., de la Luz Ayala-Madrigal, M., Gutiérrez-Angulo, M., Valle-Solis, A. E., Linares-González, L. M., González-Guzmán, R., Cruz-Guillén, D., Cedeño-Garcidueñas, A. L., Canto, P., López-Hernández, L. B."Analysis of ERCC1 and ERCC2 gene variants in osteosarcoma, colorectal and breast cancer". Oncology Letters 9, no. 4 (2015): 1657-1661. https://doi.org/10.3892/ol.2015.2894
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