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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions

  • Authors:
    • Zhong Guo
    • Shuyan Pei
    • Tianbin Si
    • Jing Li
    • Chao Jiang
    • Shangbiao Li
    • Jin Zhao
  • View Affiliations / Copyright

    Affiliations: Laboratory of Functional Science, Medical College of Northwest University for Nationalities, Lanzhou, Gansu 730030, P.R. China, Department of Gynecologic Oncology, Gansu Cancer Hospital, Lanzhou, Gansu 730050, P.R. China
  • Pages: 1790-1794
    |
    Published online on: January 26, 2015
       https://doi.org/10.3892/ol.2015.2896
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Abstract

The histone γH2AX is a marker of activated DNA damage that is overexpressed in various cancers and corresponding precursor lesions, indicating that γH2AX is a component in oncogenic transformation. The present study aimed to determine whether the immunohistochemical expression of γH2AX is involved in the progression between superficial gastritis (n=20), atrophic gastritis (n=24) and gastric carcinoma (n=79). There was no increase in γH2AX expression between superficial and atrophic gastritis, but there was a significant increase in γH2AX expression between these two conditions and gastric carcinoma (χ2=68.712; P<0.001). The expression of γH2AX in moderately‑differentiated gastric adenocarcinoma (n=49) was evidently higher compared with poorly‑differentiated gastric adenocarcinoma (n=26; χ2=14.241; P<0.01). Staining for γH2AX did not reveal a significant association between the expression of the histone and patient age, depth of invasion, lymph node metastasis or the tumor‑node‑metastasis stage of the gastric carcinoma. Overall, the present study demonstrated that enhanced γH2AX expression may be closely associated with gastric carcinoma, but is less likely to be involved in the genesis of gastric carcinoma.
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1 

Merlo LM, Pepper JW, Reid BJ and Maley CC: Cancer as an evolutionary and ecological process. Nat Rev Cancer. 6:924–935. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Bodmer W, Bielas JH and Beckman RA: Genetic instability is not a requirement for tumor development. Cancer Res. 68:3558–3560. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Woo RA, McLure KG, Lees-Miller SP, Rancourt DE and Lee PW: DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature. 394:700–704. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Bartkova J, Horejsí Z, Koed K, et al: DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 434:864–870. 2005. View Article : Google Scholar : PubMed/NCBI

5 

van Gent DC, Hoeijmakers JH and Kanaar R: Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet. 2:196–206. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Rogakou EP, Pilch DR, Orr AH, Ivanova VS and Bonner WM: DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem. 273:5858–5868. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Paull TT, Rogakou EP, Yamazaki V, et al: A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol. 10:886–895. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Zhao J, Guo Z, Zhang H, et al: The potential value of the neutral comet assay and γH2AX foci assay in assessing the radiosensitivity of carbon beam in human tumor cell lines. Radiol Oncol. 30:247–257. 2013.

9 

Gorgoulis VG, Vassiliou LV, Karakaidos P, et al: Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature. 434:907–913. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Fan C, Quan R and Feng X: ATM activation is accompanied with earlier stages of prostate tumorigenesis. Biochim Biophys Acta. 1763:1090–1097. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Spruck CH, Won KA and Reed SI: Deregulated cyclin E induces chromosome instability. Nature. 401:297–300. 1999. View Article : Google Scholar : PubMed/NCBI

12 

den Hoed CM, Holster IL, Capelle LG, et al: Follow-up of premalignant lesions in patients at risk for progression to gastric cancer. Endoscopy. 45:249–256. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Van Cutsem E, Dicato M, Geva R, et al: The diagnosis and management of gastric cancer: expert discussion and recommendations from the 12th ESMO/World Congress on Gastrointestinal Cancer, Barcelona, 2010. Ann Oncol. 5:v1–9. 2011. View Article : Google Scholar

14 

Karimi P, Islami F, Anandasabapathy S, Freedman ND and Kamangar F: Gastric cancer: descriptive epidemiology, risk factors, screening, and prevention. Cancer Epidemiol Biomarkers Prev. 23:700–713. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Sentani K, Oue N, Sakamoto N, et al: Positive immunohistochemical staining of gammaH2AX is associated with tumor progression in gastric cancers from radiation-exposed patients. Oncol Rep. 20:1131–1136. 2008.PubMed/NCBI

16 

Olive PL, Banuelos CA, Durand RE, Kim JY and Aquino-Parsons C: Endogenous and radiation-induced expression of gammaH2AX in biopsies from patients treated for carcinoma of the uterine cervix. Radiother Oncol. 94:82–89. 2010. View Article : Google Scholar

17 

Brustmann H, Hinterholzer S and Brunner A: Expression of phosphorylated histone H2AX (γ-H2AX) in normal and neoplastic squamous epithelia of the uterine cervix: an immunohistochemical study with epidermal growth factor receptor. J Gynecol Pathol. 30:76–83. 2011. View Article : Google Scholar

18 

Lu C, Zhu F, Cho YY, et al: Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell. 23:121–132. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Simão ÉM, Sinigaglia M, Bugs CA, Castro MA, Librelotto GR, Alves R and Mombach JC: Induced genome maintenance pathways in pre-cancer tissues describe an anti-cancer barrier in tumor development. Mol Biosyst. 8:3003–3009. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Ohnishi S, Ma N, Thanan R, Pinlaor S, Hammam O, Murata M and Kawanishi S: DNA damage in inflammation-related carcinogenesis and cancer stem cells. Oxid Med Cell Longev. 2013:3870142013. View Article : Google Scholar

21 

Bartek J, Bartkova J and Lukas J: The retinoblastoma protein pathway in cell cycle control and cancer. Exp Cell Res. 237:1–6. 1997. View Article : Google Scholar

22 

Olive PL: Retention of γH2AX foci as an indication of lethal DNA damage. Radiother Oncol. 101:18–23. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Feng XS, Wang YF, Hao SG, et al: Expression of Das-1, Ki67 and sulfuric proteins in gastric cardia adenocarcinoma and intestinal metaplasia lesions. Exp Ther Med. 5:1555–1558. 2013.PubMed/NCBI

24 

Ock CY, Kim EH, Choi DJ, Lee HJ, Hahm KB and Chung MH: 8-Hydroxydeoxyguanosine: not mere biomarker for oxidative stress, but remedy for oxidative stress-implicated gastrointestinal diseases. World J Gastroenterol. 18:302–308. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Hardbower DM, Peek RM Jr and Wilson KT: At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer. J Leukoc Biol. 96:201–212. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Kawanishi S and Hiraku Y: Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation. Antioxid Redox Signal. 8:1047–1058. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo Z, Pei S, Si T, Li J, Jiang C, Li S and Zhao J: Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions. Oncol Lett 9: 1790-1794, 2015.
APA
Guo, Z., Pei, S., Si, T., Li, J., Jiang, C., Li, S., & Zhao, J. (2015). Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions. Oncology Letters, 9, 1790-1794. https://doi.org/10.3892/ol.2015.2896
MLA
Guo, Z., Pei, S., Si, T., Li, J., Jiang, C., Li, S., Zhao, J."Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions". Oncology Letters 9.4 (2015): 1790-1794.
Chicago
Guo, Z., Pei, S., Si, T., Li, J., Jiang, C., Li, S., Zhao, J."Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions". Oncology Letters 9, no. 4 (2015): 1790-1794. https://doi.org/10.3892/ol.2015.2896
Copy and paste a formatted citation
x
Spandidos Publications style
Guo Z, Pei S, Si T, Li J, Jiang C, Li S and Zhao J: Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions. Oncol Lett 9: 1790-1794, 2015.
APA
Guo, Z., Pei, S., Si, T., Li, J., Jiang, C., Li, S., & Zhao, J. (2015). Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions. Oncology Letters, 9, 1790-1794. https://doi.org/10.3892/ol.2015.2896
MLA
Guo, Z., Pei, S., Si, T., Li, J., Jiang, C., Li, S., Zhao, J."Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions". Oncology Letters 9.4 (2015): 1790-1794.
Chicago
Guo, Z., Pei, S., Si, T., Li, J., Jiang, C., Li, S., Zhao, J."Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions". Oncology Letters 9, no. 4 (2015): 1790-1794. https://doi.org/10.3892/ol.2015.2896
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