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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2015 Volume 9 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review

  • Authors:
    • Jun Wang
    • Zongze Guo
    • Ermeng Ma
    • Deguang Xing
    • Bo Qiu
    • Yunjie Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 1795-1801
    |
    Published online on: January 27, 2015
       https://doi.org/10.3892/ol.2015.2903
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Abstract

Primary central nervous system lymphoma (PCNSL) is a rare, highly malignant tumor type of the nervous system and is associated with poor prognosis. To investigate the efficacy of current treatment strategies for PCNSL, the present study retrospectively analyzed the clinical and pathological features, imaging results, clinical management, and prognoses of nine patients with PCNSL. Postoperative pathological examination confirmed a diagnosis of lymphoma in all the patients and the adopted treatment regimens were as follows: Stereotactic biopsy in combination with methylprednisolone (MP) and methotrexate (MTX) and/or radiotherapy; craniotomy in combination with dexamethasone or MP and/or radiotherapy; and neuroendoscopic surgery in combination with MP and MTX. The follow‑up period was 5‑27 months with an average duration of 10.1 months. After the initial three months of follow‑up, the clinical symptoms of all the patients were significantly improved, with the tumor disappearing in seven patients and evidently reducing in size in two patients. However, six patients exhibited tumor recurrence, three of whom eventually succumbed to the disease during the follow‑up period. Currently, comprehensive treatment strategies based on a combination of stereotactic biopsy, chemotherapy and radiotherapy are recommended for the treatment of PCNSL. However, the effectiveness of these treatments remains unsatisfactory. Thus, future studies are required to investigate methods for improving the efficacy of PCNSL treatment strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Guo Z, Ma E, Xing D, Qiu B and Wang Y: Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review. Oncol Lett 9: 1795-1801, 2015.
APA
Wang, J., Guo, Z., Ma, E., Xing, D., Qiu, B., & Wang, Y. (2015). Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review. Oncology Letters, 9, 1795-1801. https://doi.org/10.3892/ol.2015.2903
MLA
Wang, J., Guo, Z., Ma, E., Xing, D., Qiu, B., Wang, Y."Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review". Oncology Letters 9.4 (2015): 1795-1801.
Chicago
Wang, J., Guo, Z., Ma, E., Xing, D., Qiu, B., Wang, Y."Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review". Oncology Letters 9, no. 4 (2015): 1795-1801. https://doi.org/10.3892/ol.2015.2903
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Guo Z, Ma E, Xing D, Qiu B and Wang Y: Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review. Oncol Lett 9: 1795-1801, 2015.
APA
Wang, J., Guo, Z., Ma, E., Xing, D., Qiu, B., & Wang, Y. (2015). Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review. Oncology Letters, 9, 1795-1801. https://doi.org/10.3892/ol.2015.2903
MLA
Wang, J., Guo, Z., Ma, E., Xing, D., Qiu, B., Wang, Y."Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review". Oncology Letters 9.4 (2015): 1795-1801.
Chicago
Wang, J., Guo, Z., Ma, E., Xing, D., Qiu, B., Wang, Y."Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review". Oncology Letters 9, no. 4 (2015): 1795-1801. https://doi.org/10.3892/ol.2015.2903
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