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Article

Mosquito coil exposure associated with small cell lung cancer: A report of three cases

  • Authors:
    • Jie Zhang
    • Hui‑Wei Qi
    • Yu‑Ping Sun
    • Hui‑Kang Xie
    • Cai‑Cun Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China, Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, P.R. China
  • Pages: 1667-1671
    |
    Published online on: February 2, 2015
       https://doi.org/10.3892/ol.2015.2922
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Abstract

Mosquito coils, which are commonly used as residential insecticides in Asia, contain different concentrations of octachlorodipropyl ether (S‑2) as a synergist or an active ingredient. As bis(chloromethyl) ether (BCME) is an extremely potent lung carcinogen that can be produced by the thermolytic degradation of S‑2, contact with mosquito coils is likely to expose individuals to a certain level of BCME, and therefore increase the risk of lung cancer. However, the significance of exposure is uncertain, as clinical and epidemiological studies concerning mosquito coil users and workers are lacking. The present study describes three cases of small cell lung cancer treated at the Shanghai Pulmonary Hospital that were likely to be the result of exposure to mosquito coils. All patients had worked in the mosquito coil manufacturing industry, with an mean occupational duration of 9.1 years, and presented with similar respiratory symptoms, such as cough and dyspnea. Upon diagnosis, no metastasis to other organs was identified in any of the cases. Subsequently, the three patients were treated with chemotherapy as well as radiotherapy in one case, however, all patients succumbed to the disease, with a mean overall survival time of 10.7 months. We conclude that contact with mosquito coils is likely to expose individuals to a level of S-2 that may increase the risk of SCLC.
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1 

Govindan R, Page N, Morgensztern D, et al: Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database. J Clin Oncol. 24:4539–4544. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Junker K, Wiethege T and Müller KM: Pathology of small-cell lung cancer. J Cancer Res Clin Oncol. 126:361–368. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Guinee DG Jr, Fishback NF, Koss MN, et al: The spectrum of immunohistochemical staining of small-cell lung carcinoma in specimens fromtransbronchial and open-lung biopsies. Am J Clin Pathol. 102:406–414. 1994.PubMed/NCBI

4 

Elias AD: Small cell lung cancer: state-of-the-art therapy in 1996. Chest. 112(4 Suppl): S251–S258. 1997. View Article : Google Scholar

5 

Murray N and Turrisi AT III: A review of first-line treatment for small-cell lung cancer. J Thorac Oncol. 1:270–278. 2006.

6 

Hann CL and Rudin CM: Management of small-cell lung cancer: incremental changes but hope for the future. Oncology (Williston Park). 22:1486–1492. 2008.

7 

Kuo YH, Lin ZZ, Yang YY, et al: Survival of patients with small cell lung carcinoma in Taiwan. Oncology. 82:19–24. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Gibbons DL, Byers LA and Kurie JM: Smoking, p53 mutation, and lung cancer. Mol Cancer Res. 12:3–13. 2014. View Article : Google Scholar : PubMed/NCBI

9 

White C: Research on smoking and lung cancer: a landmark in the history of chronic disease epidemiology. Yale J Biol Med. 63:29–46. 1990.PubMed/NCBI

10 

Espina C, Porta M, Schüz J, et al: Environmental and occupational interventions for primary prevention of cancer: a cross-sectorial policy framework. Environ Health Perspect. 121:420–426. 2013.PubMed/NCBI

11 

Vinceti M, Bottecchi I, Fan A, et al: Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis? Rev Environ Health. 27:19–41. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Krieger RI, Dinoff TM and Zhang X: Octachlorodipropyl ether (s-2) mosquito coils are inadequately studied for residential use in Asia and illegal in the United States. Environ Health Perspect. 111:1439–1442. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Pauluhn J: Overview of inhalation exposure techniques: strengths and weaknesses. Exp Toxicol Pathol. 57(Suppl 1): 111–128. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Van Duuren BL, Sivak A, Goldschmidt BM, et al: Carcinogenicity of halo-ethers. J Natl Cancer Inst. 43:481–486. 1969.PubMed/NCBI

15 

Slaga TJ, Bowden GT, Shapas BG and Boutwell RK: Macromolecular synthesis following a single application of alkylating agents used as initiators of mouse skin tumorigenesis. Cancer Res. 33:769–776. 1973.PubMed/NCBI

16 

Van Duuren BL: Direct-acting alkylating and acylating agents. DNA adduct formation, structure-activity, and carcinogenesis. Ann NY Acad Sci. 534:620–634. 1988. View Article : Google Scholar : PubMed/NCBI

17 

Gargus JL, Reese WH Jr and Rutter HA: Induction of lung aenomas in newborn mice by bis(chloromethyl) ether. Toxicol Appl Pharmacol. 15:92–96. 1969. View Article : Google Scholar : PubMed/NCBI

18 

Laskin S, Kuschner M, Drew RT, Cappiello VP and Nelson N: Tumors of the respiratory tract induced by inhalation of bis(chloromethyl)ether. Arch Environ Health. 23:135–136. 1971. View Article : Google Scholar : PubMed/NCBI

19 

Toth B: A critical review of experiments in chemical carcinogensis using newborn animals. Cancer Res. 28:727–738. 1968.PubMed/NCBI

20 

National Toxicology Program. Bis(chloromethyl) ether and technical-grade chloromethyl methyl ether. Rep Carcinog. 12:71–73. 2011.PubMed/NCBI

21 

Albert RE, Pasternack BS, Shore RE, et al: Mortality patterns among workers exposed to chloromethyl ethers--a preliminary report. Environ Health Perspect. 11:209–214. 1975.PubMed/NCBI

22 

Figueroa WG, Raszkowski R and Weiss W: Lung cancer in chloromethyl methyl ether workers. N Engl J Med. 288:1096–1097. 1973. View Article : Google Scholar : PubMed/NCBI

23 

Sakabe H: Lung cancer due to exposure to bis(chloromethyl)ether. Ind Health. 11:145–148. 1973. View Article : Google Scholar

24 

Chen SC, Wong RH, Shiu LJ, Chiou MC and Lee H: Exposure to mosquito coil smoke may be a risk factor for lung cancer in Taiwan. J Epidemiol. 18:19–25. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Tang L, Lim WY, Eng P, Leong SS, Lim TK, Ng AW, Tee A and Seow A: Lung cancer in Chinese women: evidence for an interaction between tobacco smoking and exposure to inhalants in the indoor environment. Environ Health Perspect. 118:1257–1260. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Chen ZM: Tri-dimension pollution chain in tea ecosystem and its control. Scientia Agricultura Sinica. 40:948–958. 2007.

27 

Zeng CH, Tang M and Xiong LL: Effect of Octachlorodipropyl Ether Inhalation on Oxidative Damage in Mice. J Environ Occup Med. 23:151–153. 2006.

28 

Maher KV and DeFonso LR: Respiratory cancer among chloromethyl ether workers. J Natl Cancer Inst. 78:839–843. 1987.PubMed/NCBI

29 

Gowers DS, DeFonso LR, Schaffer P, et al: Incidence of respiratory cancer among workers exposed to chloromethyl-ethers. Am J Epidemiol. 137:31–42. 1993.PubMed/NCBI

30 

Weiss W and Boucot KR: The respiratory effects of chloromethyl methyl ether. JAMA. 234:1139–1142. 1975. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Qi HW, Sun YP, Xie HK and Zhou CC: Mosquito coil exposure associated with small cell lung cancer: A report of three cases. Oncol Lett 9: 1667-1671, 2015.
APA
Zhang, J., Qi, H., Sun, Y., Xie, H., & Zhou, C. (2015). Mosquito coil exposure associated with small cell lung cancer: A report of three cases. Oncology Letters, 9, 1667-1671. https://doi.org/10.3892/ol.2015.2922
MLA
Zhang, J., Qi, H., Sun, Y., Xie, H., Zhou, C."Mosquito coil exposure associated with small cell lung cancer: A report of three cases". Oncology Letters 9.4 (2015): 1667-1671.
Chicago
Zhang, J., Qi, H., Sun, Y., Xie, H., Zhou, C."Mosquito coil exposure associated with small cell lung cancer: A report of three cases". Oncology Letters 9, no. 4 (2015): 1667-1671. https://doi.org/10.3892/ol.2015.2922
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Qi HW, Sun YP, Xie HK and Zhou CC: Mosquito coil exposure associated with small cell lung cancer: A report of three cases. Oncol Lett 9: 1667-1671, 2015.
APA
Zhang, J., Qi, H., Sun, Y., Xie, H., & Zhou, C. (2015). Mosquito coil exposure associated with small cell lung cancer: A report of three cases. Oncology Letters, 9, 1667-1671. https://doi.org/10.3892/ol.2015.2922
MLA
Zhang, J., Qi, H., Sun, Y., Xie, H., Zhou, C."Mosquito coil exposure associated with small cell lung cancer: A report of three cases". Oncology Letters 9.4 (2015): 1667-1671.
Chicago
Zhang, J., Qi, H., Sun, Y., Xie, H., Zhou, C."Mosquito coil exposure associated with small cell lung cancer: A report of three cases". Oncology Letters 9, no. 4 (2015): 1667-1671. https://doi.org/10.3892/ol.2015.2922
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