Lipid-rich carcinoma of the breast: A report of two cases and a literature review

Cong,Yizi; Lin,Jun; Qiao,Guangdong; Zou,Haidong; Wang,Xingmiao; Li,Xiaohui; Li,Yalun; Zhu,Shiguang

doi:10.3892/ol.2015.2924

April-2015 Volume 9 Issue 4

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April-2015 Volume 9 Issue 4

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Article

Lipid-rich carcinoma of the breast: A report of two cases and a literature review

Authors:
- Yizi Cong
- Jun Lin
- Guangdong Qiao
- Haidong Zou
- Xingmiao Wang
- Xiaohui Li
- Yalun Li
- Shiguang Zhu
View Affiliations / Copyright

Affiliations: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to the Medical College of Qingdao University, Yantai, Shandong 264400, P.R. China
Pages: 1729-1732
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Published online on: February 3, 2015

https://doi.org/10.3892/ol.2015.2924
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Abstract

Lipid‑rich carcinoma of the breast is extremely rare with no standard guidelines for treatment with poor patient prognosis. In the present study, the clinical features, imaging results, pathology, immunohistochemistry, treatment and prognoses of two patients with lipid‑rich carcinoma of the breast were analyzed. Two patients were admitted to the Yantai Yuhuangding Hospital Affiliated to the Medical College of Qingdao University (Yantai, Shandong, China) for examination of a palpable mass in the breast. Enlarged lymph nodes were found in the axilla of each patient. The results of mammography and echography imaging suggested the presence of malignancy. A modified radical mastectomy was performed in each patient, and pathological examination revealed atypical large vacuolated cells arranged in clusters and confirmed lipid‑rich carcinoma and lymph node metastases. The tumor tissue of patient one was immunohistochemically positive for estrogen receptor (ER), p53, p120 and E‑cadherin, and negative for progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER‑2), with a Ki‑67 labeling index of 50%. The tumor tissue of patient two was immunohistochemically positive for p53, and negative for ER, PR, HER‑2 and cytokeratin 5/6, with a Ki‑67 labeling index of 30%. Post‑surgery, patient one was administered chemotherapy for six cycles, radiotherapy and endocrine therapy in the form of anastrozole. Patient two was administered three cycles of chemotherapy without radiotherapy. Subsequent to being followed up for 25 months and 13 months, respectively, there was no evidence of recurrence or distant metastasis in patient one or two, respectively.

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1	Guan B, Wang H, Cao S, et al: Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases. Ann Diagn Pathol. 15:225–232. 2011. View Article : Google Scholar : PubMed/NCBI
2	Tavassoli FA and Devilee PE: World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of the Breast and Female Genital Organs. IARC Press; Lyon, France: 2003
3	Umekita Y, Yoshida A, Sagara Y and Yoshida H: Lipid-secreting carcinoma of the breast: a case report and Review of the Literature. Breast Cancer. 5:171–173. 1998. View Article : Google Scholar
4	Kurisu Y, Tsuji M, Shibayama Y, Takahashi Y and Nohara T: Intraductal lipid-rich carcinoma of the breast with a component of glycogen-rich carcinoma. J Breast Cancer. 15:135–138. 2012. View Article : Google Scholar : PubMed/NCBI
5	Shi P, Wang M, Zhang Q and Sun J: Lipid-rich carcinoma of the breast. A clinicopathological study of 49 cases. Tumori. 94:342–346. 2008.PubMed/NCBI
6	Aboumrad MH, Horn RC Jr and Fine G: Lipid-secreting mammary carcinoma. Report of a case associated with Paget’s disease of the nipple. Cancer. 16:521–525. 1963. View Article : Google Scholar : PubMed/NCBI
7	Moritani S, Ichihara S, Hasegawa M, et al: Intracytoplasmic lipid accumulation in apocrine carcinoma of the breast evaluated with adipophilin immunoreactivity: a possible link between apocrine carcinoma and lipid-rich carcinoma. Am J Surg Pathol. 35:861–867. 2011. View Article : Google Scholar : PubMed/NCBI
8	Ramos CV and Taylor HB: Lipid-rich carcinoma of the breast. A clinicopathologic analysis of 13 examples. Cancer. 33:812–819. 1974. View Article : Google Scholar : PubMed/NCBI
9	Vera-Sempere F and Llombart-Bosch A: Lipid-rich versus lipid-secreting carcinoma of the mammary gland. Pathol Res Pract. 180:553–558. 1985. View Article : Google Scholar : PubMed/NCBI
10	Machalekova K, Kajo K and Bencat M: Unusual occurrence of rare lipid-rich carcinoma and conventional invasive ductal carcinoma in the one breast: case report. Case Rep Pathol. 2012:3870452012.PubMed/NCBI
11	Kimura A, Miki H, Yuri T, Hatano T and Tsubura A: A case report of lipid-rich carcinoma of the breast including histological characteristics and intrinsic subtype profile. Case Rep Oncol. 4:275–280. 2011. View Article : Google Scholar : PubMed/NCBI
12	Varga Z, Robl C, Spycher M, Burger D and Caduff R: Metaplastic lipid-rich carcinoma of the breast. Pathol Int. 48:912–916. 1998. View Article : Google Scholar : PubMed/NCBI
13	National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (Breast Cancer): V.3.2014. http://www.nccn.org/professionals/physician_gls/pdf/breast.pdf. Accessed January 26, 2015
14	Reis-Filho JS, Fulford LG, Lakhani SR and Schmitt FC: Pathologic quiz case: a 62-year-old woman with a 4.5-cm nodule in the right breast. Lipid-rich breast carcinoma. Arch Pathol Lab Med. 127:e396–e398. 2003.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Lipid-rich carcinoma of the breast: A report of two cases and a literature review

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