Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2015 Volume 9 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2015 Volume 9 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer

  • Authors:
    • Ge Ge Guan
    • Wen Bo Wang
    • Bing Xin Lei
    • Qiao Li Wang
    • Lin Wu
    • Zhen Ming Fu
    • Fu Xiang Zhou
    • Yun Feng Zhou
  • View Affiliations / Copyright

    Affiliations: Hubei Key Laboratory of Tumor Biological Behaviors, Hubei Cancer Clinical Study Center, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Guan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1567-1574
    |
    Published online on: February 3, 2015
       https://doi.org/10.3892/ol.2015.2926
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Human telomerase reverse transcriptase (hTERT) is a critical factor in unlimited cell proliferation and immortalization, with numerous studies demonstrating that high expression of hTERT is a poor prognostic factor in various types of cancer. Ubiquitin‑conjugating enzyme E2D 3 (UBE2D3) is a member of the E2 family, and participates in the ubiquitin proteasome pathway to regulate basic cellular activities, such as cell cycle control, the DNA damage response, apoptosis, and tumorigenesis. Our previous study initially determined that downregulation of UBE2D3 expression increases hTERT expression and cell proliferation, however, the association between the expression of these two proteins and their functions in cancer tissues remains unknown. Therefore, the protein expression levels of hTERT and UBE2D3 were evaluated in 150 esophageal cancer and 30 adjacent healthy tissue samples by performing immunohistochemical analysis. Concurrently, the clinicopathological data of the enrolled patients were obtained to allow correlation analysis. It was identified that the expression of hTERT in the esophageal cancer tissues was significantly higher compared with that of the adjacent tissues (P=0.015), however, the expression of UBE2D3 was significantly lower in esophageal cancer tissues than the adjacent tissues (P=0.001). Additionally, the study demonstrated that hTERT was significantly upregulated in poorly‑differentiated, advanced tumor‑node‑metastasis (TNM) stage cancer tissues (P<0.05 for all), however, UBE2D3 expression was downregulated in poorly‑differentiated, lymph node invaded cancer tissues and recurrent cases. It was also identified that traditional factors, including tumor location, T stage, lymph node status, TNM stage, and molecular factors of hTERT and UBE2D3, were significantly associated with overall survival time (P<0.05 for all). Furthermore, UBE2D3, lymph node status and tumor location were independent prognostic factors for esophageal cancer in multivariate analysis. Most notably, hTERT and UBE2D3 expression were negatively correlated with each other. In conclusion, the findings of the present study indicated that hTERT and UBE2D3 proteins appear to be involved in the development of esophageal cancer, that UBE2D3 may a positive prognostic factor for esophageal cancer, and that UBE2D3 and hTERT expression levels are inversely correlated.
View Figures

Figure 1

Figure 2

View References

1 

Yang H and Chen YX: Improvement analysis of article quality in World Journal of Gastroenterology during 2008–2012. World J Gastroenterol. 19:7830–7835. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Mao WM, Zheng WH and Ling ZQ: Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev. 12:2461–2466. 2011.

3 

Wang X, Fan JC, Wang AR, et al: Epidemiology of esophageal cancer in Yanting - regional report of a national screening programme in China. Asian Pac J Cancer Prev. 14:2429–2432. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Lin Y, Totsuka Y, He Y, et al: Epidemiology of esophageal cancer in Japan and China. J Epidemiol. 23:233–242. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Y: Epidemiology of esophageal cancer. World J Gastroenterol. 19:5598–5606. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Gertler R, Stein HJ, Langer R, et al: Long-term outcome of 2920 patients with cancers of the esophagus and esophagogastric junction: evaluation of the New Union Internationale Contre le Cancer/American Joint Cancer Committee staging system. Ann Surg. 253:689–698. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Lu W, Zhang Y, Liu D, et al: Telomeres - structure, function, and regulation. Exp Cell Res. 319:133–141. 2013. View Article : Google Scholar

8 

Philippi C, Loretz B, Schaefer UF and Lehr CM: Telomerase as an emerging target to fight cancer - opportunities and challenges for nanomedicine. J Control Release. 146:228–240. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Counter CM, Meyerson M, Eaton EN, et al: Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene. 16:1217–1222. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Ulaner GA, Hu JF, Vu TH, et al: Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT) transcription and by alternate splicing of hTERT transcripts. Cancer Res. 58:4168–4172. 1998.PubMed/NCBI

11 

Proctor A, Brownhill SC and Burchill SA: The promise of telomere length, telomerase activity and its regulation in the translocation-dependent cancer ESFT; clinical challenges and utility. Biochim Biophys Acta. 1792:260–274. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Simsek BC, Pehlivan S and Karaoglu A: Human telomerase reverse transcriptase expression in colorectal tumors: correlations with immunohistochemical expression and clinicopathologic features. Ann Diagn Pathol. 14:413–417. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Wang G, Wang W, Zhou J and Yang X: Correlation between telomerase activity and matrix metalloproteinases 2 expression in gastric cancer. Cancer Biomark. 13:21–28. 2013.PubMed/NCBI

14 

Poremba C, Heine B, Diallo R, et al: Telomerase as a prognostic marker in breast cancer: high-throughput tissue microarray analysis of hTERT and hTR. J Pathol. 198:181–189. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Tu Y, Chen C, Pan J, et al: The Ubiquitin Proteasome Pathway (UPP) in the regulation of cell cycle control and DNA damage repair and its implication in tumorigenesis. Int J Clin Exp Pathol. 5:726–738. 2012.PubMed/NCBI

16 

Amm I, Sommer T and Wolf DH: Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system. Biochim Biophys Acta. 1843:182–196. 2014. View Article : Google Scholar

17 

Clague MJ and Urbé S: Ubiquitin: same molecule, different degradation pathways. Cell. 143:682–685. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Kleiger G and Mayor T: Perilous journey: a tour of the ubiquitin-proteasome system. Trends Cell Biol. 24:352–359. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Wang W, Yang L, Hu L, et al: Inhibition of UBE2D3 expression attenuates radiosensitivity of MCF-7 human breast cancer cells by increasing hTERT expression and activity. PLoS One. 8:e646602013. View Article : Google Scholar : PubMed/NCBI

20 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumours. 7th edition. Wiley-Blackwell; sWest Sussex: 2009

21 

Yang CH, Hung WC, Wang SL, et al: Immunoexpression and prognostic role of hTERT and cyclin D1 in urothelial carcinoma. APMIS. 116:309–316. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Fujita T, Ikeda H, Kawasaki K, et al: Clinicopathological relevance of UbcH10 in breast cancer. Cancer Sci. 100:238–248. 2009. View Article : Google Scholar

23 

Kumaki F, Kawai T, Hiroi S, et al: Telomerase activity and expression of human telomerase RNA component and human telomerase reverse transcriptase in lung carcinomas. Hum Pathol. 32:188–195. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Yam PC, Tong D and Law S: Comparisons of sixth and seventh edition of the American Joint Cancer Committee staging systems for esophageal cancer. Ann Surg Oncol. 21:583–588. 2014. View Article : Google Scholar

25 

Hsu PK, Wu YC, Chou TY, et al: Comparison of the 6th and 7th editions of the American Joint Committee on Cancer tumor-node-metastasis staging system in patients with resected esophageal carcinoma. Ann Thorac Surg. 89:1024–1031. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Hong JC, Murphy JD, Wang SJ, et al: Chemoradiotherapy before and after surgery for locally advanced esophageal cancer: a SEER-Medicare analysis. Ann Surg Oncol. 20:3999–4007. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Yang HX, Hou X, Liu QW, et al: Tumor location does not impact long-term survival in patients with operable thoracic esophageal squamous cell carcinoma in China. Ann Thorac Surg. 93:1861–1866. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Marjanovic G, Schricker M, Walch A, et al: Detection of lymph node involvement by cytokeratin immunohistochemistry is an independent prognostic factor after curative resection of esophageal cancer. J Gastrointest Surg. 15:29–37. 2011. View Article : Google Scholar

29 

Dhupar R, Correa AM, Ajani J, et al: Concordance of studies for nodal staging is prognostic for worse survival in esophageal cancer. Dis Esophagus. 27:770–776. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Vallböhmer D, Brabender J, Metzger R and Hölscher AH: Genetics in the pathogenesis of esophageal cancer: possible predictive and prognostic factors. J Gastrointest Surg. 14(Suppl 1): S75–S80. 2010. View Article : Google Scholar

31 

Cheung PY, Deng W, Man C, et al: Genetic alterations in a telomerase-immortalized human esophageal epithelial cell line: Implications for carcinogenesis. Cancer Lett. 293:41–51. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Okawa T, Michaylira CZ, Kalabis J, et al: The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev. 21:2788–2803. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Sakabe R, Murakami Y, Uemura K, et al: Prognostic significance of telomerase activity and human telomerase reverse transcriptase expression in ampullary carcinoma. Ann Surg Oncol. 19:3072–3080. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Page RC, Pruneda JN, Amick J, et al: Structural insights into the conformation and oligomerization of E2~ubiquitin conjugates. Biochemistry. 51:4175–4187. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Ye Y and Rape M: Building ubiquitin chains: E2 enzymes at work. Nat Rev Mol Cell Biol. 10:755–764. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Adams J: The proteasome: structure, function, and role in the cell. Cancer Treat Rev. 29(Suppl 1): 3–9. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Khanna-Gupta A and Berliner N: ATRA: Finding targeted APL therapy targets. Blood. 110:476–477. 2007. View Article : Google Scholar

38 

Mittal MK, Singh K, Misra S and Chaudhuri G: SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination. J Biol Chem. 286:469–479. 2011. View Article : Google Scholar :

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Guan GG, Wang WB, Lei BX, Wang QL, Wu L, Fu ZM, Zhou FX and Zhou YF: UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer. Oncol Lett 9: 1567-1574, 2015.
APA
Guan, G.G., Wang, W.B., Lei, B.X., Wang, Q.L., Wu, L., Fu, Z.M. ... Zhou, Y.F. (2015). UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer. Oncology Letters, 9, 1567-1574. https://doi.org/10.3892/ol.2015.2926
MLA
Guan, G. G., Wang, W. B., Lei, B. X., Wang, Q. L., Wu, L., Fu, Z. M., Zhou, F. X., Zhou, Y. F."UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer". Oncology Letters 9.4 (2015): 1567-1574.
Chicago
Guan, G. G., Wang, W. B., Lei, B. X., Wang, Q. L., Wu, L., Fu, Z. M., Zhou, F. X., Zhou, Y. F."UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer". Oncology Letters 9, no. 4 (2015): 1567-1574. https://doi.org/10.3892/ol.2015.2926
Copy and paste a formatted citation
x
Spandidos Publications style
Guan GG, Wang WB, Lei BX, Wang QL, Wu L, Fu ZM, Zhou FX and Zhou YF: UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer. Oncol Lett 9: 1567-1574, 2015.
APA
Guan, G.G., Wang, W.B., Lei, B.X., Wang, Q.L., Wu, L., Fu, Z.M. ... Zhou, Y.F. (2015). UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer. Oncology Letters, 9, 1567-1574. https://doi.org/10.3892/ol.2015.2926
MLA
Guan, G. G., Wang, W. B., Lei, B. X., Wang, Q. L., Wu, L., Fu, Z. M., Zhou, F. X., Zhou, Y. F."UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer". Oncology Letters 9.4 (2015): 1567-1574.
Chicago
Guan, G. G., Wang, W. B., Lei, B. X., Wang, Q. L., Wu, L., Fu, Z. M., Zhou, F. X., Zhou, Y. F."UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer". Oncology Letters 9, no. 4 (2015): 1567-1574. https://doi.org/10.3892/ol.2015.2926
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team