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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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April-2015 Volume 9 Issue 4

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Case Report

Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report

  • Authors:
    • Yoshiko Okita
    • Masahiro Nonaka
    • Toru Umehara
    • Yonehiro Kanemura
    • Yoshinori Kodama
    • Masayuki Mano
    • Shin Nakajima
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan, Department of Central Laboratory and Surgical Pathology, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan
  • Pages: 1885-1888
    |
    Published online on: February 6, 2015
       https://doi.org/10.3892/ol.2015.2940
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Abstract

The prognosis of leptomeningeal dissemination of recurrent glioblastoma is poor, and chemotherapy results in minimal palliative efficacy. Temozolomide (TMZ) is an established therapy for patients with malignant glioma and the standard of care in parenchymal gliomas; however, few reports have been published with regard to its use for the treatment of leptomeningeal dissemination. Only one report has indicated the radiographic response of leptomeningeal dissemination to a TMZ rechallenge, suggesting a potential causative effect. While bevacizumab is an effective therapy for recurrent glioblastoma, its effect on leptomeningeal dissemination of recurrent glioblastoma remains unclear. The present study reports a case of leptomeningeal dissemination of recurrent glioblastoma in which transient neurological and radiological improvement was observed following chemotherapy with TMZ and bevacizumab. However, five months after the diagnosis of leptomeningeal dissemination the patient succumbed to the disease.
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1 

Stupp R, Mason WP, van den Bent MJ, et al; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Lamborn KR, Yung WK, Chang SM, et al; North American Brain Tumor Consortium. Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas. Neuro Oncol. 10:162–170. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Wong ET, Hess KR, Gleason MJ, et al: Outcomes and prognostic factors in recurrent glioma patients enrolled onto phase II clinical trials. J Clin Oncol. 17:2572–2578. 1999.PubMed/NCBI

4 

Arita N, Taneda M and Hayakawa T: Leptomeningeal dissemination of malignant gliomas. Incidence, diagnosis and outcome. Acta Neurochir (Wien). 126:84–92. 1994. View Article : Google Scholar

5 

Awad I, Bay JW and Rogers L: Leptomeningeal metastasis from supratentorial malignant gliomas. Neurosurgery. 19:247–251. 1986. View Article : Google Scholar : PubMed/NCBI

6 

Vertosick FT Jr and Selker RG: Brain stem and spinal metastases of supratentorial glioblastoma multiforme: a clinical series. Neurosurgery. 27:516–522. 1990. View Article : Google Scholar : PubMed/NCBI

7 

Delattre JY, Walker RW and Rosenblum MK: Leptomeningeal gliomatosis with spinal cord or cauda equina compression: a complication of supratentorial gliomas in adults. Acta Neurol Scand. 79:133–139. 1989. View Article : Google Scholar : PubMed/NCBI

8 

Nandipati S and Demopoulos A: Leptomeningeal dissemination of anaplastic glioma: prolonged survival in two patients treated with temozolomide. J Neurooncol. 105:663–665. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Narita Y: Drug review: Safety and efficacy of bevacizumab for glioblastoma and other brain tumors. Jpn J Clin Oncol. 43:587–595. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Groves MD, DeGroot J, Tremont I, Forman A, Kang S, Pei BL, et al: A pilot study of systemically administered bevacizumab with neoplastic meningitis NM: imaging, clinical, CSF, and biomarker outcomes. Neuro Oncol (OT-02). 13:iii85–iii91. 2011.

11 

Fiorentino A, Caivano R, Chiumento C, Cozzolino M and Fusco V: Radiotherapy and bevacizumab for intramedullary and leptomenigeal metastatic glioblastoma: a case report and review of the literature. Int J Neurosci. 122:691–694. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Hübner F, Braun V and Richter HP: Case reports of symptomatic metastases in four patients with primary intracranial gliomas. Acta Neurochir (Wien). 143:25–29. 2001. View Article : Google Scholar

13 

Onda K, Tanaka R, Takahashi H, Takeda N and Ikuta F: Cerebral glioblastoma with cerebrospinal fluid dissemination: a clinicopathological study of 14 cases examined by complete autopsy. Neurosurgery. 25:533–540. 1989. View Article : Google Scholar : PubMed/NCBI

14 

Chamberlain MC: Combined-modality treatment of leptomeningeal gliomatosis. Neurosurgery. 52:324–330. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Miller K, Wang M, Gralow J, et al: Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med. 357:2666–2676. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Yang JC, Haworth L, Sherry RM, et al: A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med. 349:427–434. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Giantonio BJ, Catalano PJ, Meropol NJ, et al; Eastern Cooperative Oncology Group Study E3200. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol. 25:1539–1544. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 350:2335–2342. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Sandler A, Gray R, Perry MC, et al: Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med. 355:2542–2550. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Vincent A, Lesser G, Brown D, et al: Prolonged regression of metastatic leptomeningeal breast cancer that has failed conventional therapy: a case report and review of the literature. J Breast Cancer. 16:122–126. 2013. View Article : Google Scholar : PubMed/NCBI

21 

De Braganca KC, Janjigian YY, Azzoli CG, et al: Efficacy and safety of bevacizumab in active brain metastases from non-small cell lung cancer. J Neurooncol. 100:443–447. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Ku GY, Krol G and Ilson DH: Successful treatment of leptomeningeal disease in colorectal cancer with a regimen of bevacizumab, temozolomide, and irinotecan. J Clin Oncol. 25:e14–e16. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Le Rhun E, Taillibert S and Chamberlain MC: Carcinomatous meningitis: Leptomeningeal metastases in solid tumors. Surg Neurol Int. 4:S265–S288. 2013.PubMed/NCBI

24 

Mohan A and Ponnusankar S: Newer therapies for the treatment of metastatic breast cancer: a clinical update. Indian J Pharm Sci. 75:251–261. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Foubert F, Matysiak-Budnik T and Touchefeu Y: Options for metastatic colorectal cancer beyond the second line of treatment. Dig Liver Dis. 46:105–112. 2014. View Article : Google Scholar

26 

Folkman J: Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov. 6:273–286. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Jain RK: Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 307:58–62. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Jain RK, Duda DG, Clark JW and Loeffler JS: Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol. 3:24–40. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Chamberlain MC and Johnston SK: Salvage therapy with single agent bevacizumab for recurrent glioblastoma. J Neurooncol. 96:259–269. 2010. View Article : Google Scholar

30 

Wong ET, Gautam S, Malchow C, Lun M, Pan E and Brem S: Bevacizumab for recurrent glioblastoma multiforme: a meta-analysis. J Natl Compr Canc Netw. 9:403–407. 2011.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Okita Y, Nonaka M, Umehara T, Kanemura Y, Kodama Y, Mano M and Nakajima S: Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report. Oncol Lett 9: 1885-1888, 2015.
APA
Okita, Y., Nonaka, M., Umehara, T., Kanemura, Y., Kodama, Y., Mano, M., & Nakajima, S. (2015). Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report. Oncology Letters, 9, 1885-1888. https://doi.org/10.3892/ol.2015.2940
MLA
Okita, Y., Nonaka, M., Umehara, T., Kanemura, Y., Kodama, Y., Mano, M., Nakajima, S."Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report". Oncology Letters 9.4 (2015): 1885-1888.
Chicago
Okita, Y., Nonaka, M., Umehara, T., Kanemura, Y., Kodama, Y., Mano, M., Nakajima, S."Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report". Oncology Letters 9, no. 4 (2015): 1885-1888. https://doi.org/10.3892/ol.2015.2940
Copy and paste a formatted citation
x
Spandidos Publications style
Okita Y, Nonaka M, Umehara T, Kanemura Y, Kodama Y, Mano M and Nakajima S: Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report. Oncol Lett 9: 1885-1888, 2015.
APA
Okita, Y., Nonaka, M., Umehara, T., Kanemura, Y., Kodama, Y., Mano, M., & Nakajima, S. (2015). Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report. Oncology Letters, 9, 1885-1888. https://doi.org/10.3892/ol.2015.2940
MLA
Okita, Y., Nonaka, M., Umehara, T., Kanemura, Y., Kodama, Y., Mano, M., Nakajima, S."Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report". Oncology Letters 9.4 (2015): 1885-1888.
Chicago
Okita, Y., Nonaka, M., Umehara, T., Kanemura, Y., Kodama, Y., Mano, M., Nakajima, S."Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report". Oncology Letters 9, no. 4 (2015): 1885-1888. https://doi.org/10.3892/ol.2015.2940
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