Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2015 Volume 9 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2015 Volume 9 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study

  • Authors:
    • Jianzhong Yu
    • We Shi
    • Rui Zhao
    • Xiaofeng Gao
    • Hao Li
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Children's Hospital of Fudan University, Shanghai 201102, P.R. China
  • Pages: 1651-1656
    |
    Published online on: February 9, 2015
       https://doi.org/10.3892/ol.2015.2943
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of present study was to evaluate the incidence, clinical symptoms, pathological characteristics, surgical treatment strategies and prognosis of brain tumors in children aged two and under. The current study obtained data regarding 32 consecutive infants and young children aged two years and under, who were treated for brain tumors in the Children's Hospital of Fudan University (Shanghai, China) between 2003 and 2013. The types of tumor, clinical manifestations, location, histological features, applied treatment strategies and outcomes were retrospectively evaluated. The male to female ratio was 1.13:1, and among a total of 32 tumors, 14 (43.8%) were suptratentorial and 18 (56.3%) were infratentorial. Intracranial hypertension was the most common onset symptom, and astrocytoma was the most common tumor type (10 cases; 31.3%), followed by ependymoma (nine cases; 28.1%) and medulloblastoma (six cases; 18.8%). Surgical tumor resection was performed in 20 patients (62.5%), who experienced a mean post‑operative survival time of 67.6 months. By contrast, conservative treatment with medications was administered in 12 patients (37.5%), with a mean survival time of 25.3 months. Furthermore, four patients underwent conservative therapy combined with ventriculoperitoneal shunting to relieve intracranial pressure arising from cerebrospinal fluid accumulation, resulting in a mean survival time of 10.5 months. In conclusion, the present study indicates that surgical tumor resection may improve the overall prognosis of infants and young children aged two years and under who presented with brain tumors. In addition, ventriculoperitoneal shunts may facilitate pre‑ and post‑operative improvement in clinical symptoms by relieving intracranial pressure; however, the shunts do not appear to increase long‑term survival. Furthermore, high surgical risk is an important prognostic factor in this pediatric patient population.
View Figures

Figure 1

Figure 2

View References

1 

Baldwin RT and Preston-Martin S: Epidemiology of brain tumors in childhood - a review. Toxicol Appl Pharmacol. 199:118–131. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Magnani C, Aareleid T, Viscomi S, Pastore G and Berrino F; EUROCARE Working Group. Variation in survival of children with central nervous system (CNS) malignancies diagnosed in Europe between 1978 and 1992: the EUROCARE study. Eur J Cancer. 37:711–721. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Macedoni-Luksic M, Jereb B and Todorovski L: Long-term sequelae in children treated for brain tumors: impairments, disability, and handicap. Pediatr Hematol Oncol. 20:89–101. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Aarsen FK, Paquier PF, Reddingius RE, Streng IC, Arts WF, Evera-Preesman M and Catsman-Berrevoets CE: Functional outcome after low-grade astrocytoma treatment in childhood. Cancer. 106:396–402. 2006. View Article : Google Scholar

5 

Raaschou-Nielsen O, Sørensen M, Carstensen H, Jensen T, Bernhardtsen T, Gjerris F and Schmiegelow K: Increasing incidence of childhood tumours of the central nervous system in Denmark, 1980–1996. Br J Cancer. 95:416–422. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Sala F, Colarusso E, Mazza C, Talacchi A and Bricolo A: Brain tumors in children under 3 years of age. Recent experience (1987–1997) in 39 patients. Pediatr Neurosurg. 31:16–26. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Isaacs H Jr: I. Perinatal brain tumors: a review of 250 cases. Pediatr Neurol. 27:249–261. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Bishop AJ, McDonald MW, Chang AL and Esiashvili N: Infant brain tumors: incidence, survival, and the role of radiation based on Surveillance, Epidemiology, and End Results (SEER) Data. Int J Radiat Oncol Biol Phys. 82:341–347. 2012. View Article : Google Scholar

9 

Johnson MW, Eberhart CG, Perry A, Tihan T, Cohen KJ, Rosenblum MK, Rais-Bahrami S, Goldthwaite P and Burger PC: Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors. Am J Surg Pathol. 34:1783–1791. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Furuta T, Tabuchi A, Adachi Y, Mizumatsu S, Tamesa N, Ichikawa T, Tamiya T, Matsumoto K and Ohmoto T: Primary brain tumors in children under age 3 years. Brain Tumor Pathol. 15:7–12. 1998. View Article : Google Scholar

11 

Hanieh S, Hanieh A, Bourne AJ and Byard RW: Brain tumours in infancy: a clinicopathological study. J Clin Neurosci. 4:181–185. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Larouche V, Huang A, Bartels U and Bouffet E: Tumors of the central nervous system in the first year of life. Pediatr Blood Cancer. 49(Suppl): 1074–1082. 2007. View Article : Google Scholar : PubMed/NCBI

13 

DiRosso C, Ianelli A and Papacci F: Infantile brain tumors. Tumors of the Pediatric Central Nervous System. 2. Keating RF, Goodrich JT and Packer R: Thieme; New York: pp. 3942013

14 

Magdum SA: Neonatal brain tumours - a review. Early Hum Dev. 86:627–631. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Thorp N: Basic principles of paediatric radiotherapy. Clin Oncol (R Coll Radiol). 25:3–10. 2013. View Article : Google Scholar

16 

Kim YH, Song SW, Lee JY, et al: Surgically treated brain tumors: a retrospective case series of 10,009 cases at a single institution. World Neurosurg. 76:555–563. 2011. View Article : Google Scholar

17 

Soriano SG, Eldredge EA and Rockoff MA: Pediatric neuroanesthesia. Anesthesiol Clin North America. 20:389–404. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Gaggero R, Consales A, Fazzini F, et al: Epilepsy associated with supratentorial brain tumors under 3 years of life. Epilepsy Res. 87:184–189. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Dunham C, Pillai S and Steinbok P: Infant brain tumors: a neuropathologic population-based institutional reappraisal. Hum Pathol. 43:1668–1676. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Ramanan M and Chaseling R: Paediatric brain tumours treated at a single, tertiary paediatric neurosurgical referral centre from 1999 to 2010 in Australia. J Clin Neurosci. 19:1387–1391. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Ibrahim K and Appleton R: Seizures as the presenting symptom of brain tumours in children. Seizure. 13:108–112. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Balestrini MR, Micheli R, et al: Brain tumors with symptomatic onset in the first two years of life. Childs Nerv Syst. 10:104–110. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Rickert CH, Probst-Cousin S and Gullotta F: Primary intracranial neoplasms of infancy and early childhood. Childs Nerv Syst. 13:507–513. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Rangwala LM and Liu GT: Pediatric idiopathic intracranial hypertension. Surv Ophthalmol. 52:597–617. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Cohen BH: Headaches as a symptom of neurological disease. Semin Pediatr Neurol. 2:144–150. 1995. View Article : Google Scholar : PubMed/NCBI

27 

Fleming AJ and Chi SN: Brain tumors in children. Curr Probl Pediatr Adolesc Health Care. 42:80–103. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Orbach D, Sarnacki S, Brisse HJ, et al: Neonatal cancer. Lancet Oncol. 14:e609–e620. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Khan SN and Sepahdari AR: Orbital masses: CT and MRI of common vascular lesions, benign tumors, and malignancies. Saudi J Ophthalmol. 26:373–383. 2012. View Article : Google Scholar

30 

Parmar HA, Pruthi S, Ibrahim M and Gandhi D: Imaging of congenital brain tumors. Semin Ultrasound CT MR. 32:578–589. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Koob M and Girard N: Cerebral tumors: specific features in children. Diagn Interv Imaging. 95:965–983. 2014. View Article : Google Scholar : PubMed/NCBI

32 

McGirt MJ, Chaichana KL, Gathinji M, et al: Independent association of extent of resection with survival in patients with malignant brain astrocytoma. J Neurosurg. 110:156–162. 2009. View Article : Google Scholar

33 

Khalil EM: Treatment results of adults and children with medulloblastoma NCI, Cairo University experience. J Egypt Natl Canc Inst. 20:175–186. 2008.PubMed/NCBI

34 

Vabulas M, Kumar VA, Hamilton JD, Martinez JJ, Rao G, Sawaya R and Prabhu SS: Real-time atlas-based stereotactic neuronavigation. Neurosurgery. 74:128–134. 2014. View Article : Google Scholar

35 

Steinbok P, Mangat JS, Kerr JM, Sargent M, Suryaningtyas W, Singhal A and Cochrane D: Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas. Childs Nerv Syst. 29:1269–1275. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Roujeau T, Di Rocco F, Dufour C, et al: Shall we treat hydrocephalus associated to brain stem glioma in children? Childs Nerv Syst. 27:1735–1739. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Han YP, Zhao Y, He XG and Ma J: Peritoneal metastasis of third ventricular atypical teratoid/rhabdoid tumor after VP shunt implantation for unexplained hydrocephalus. World J Pediatr. 8:367–370. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Garzón M, García-Fructuoso G, Guillén A, Suñol M, Mora J and Cruz O: Brain stem tumors in children and adolescents: single institutional experience. Childs Nerv Syst. 29:1321–1331. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu J, Shi W, Zhao R, Gao X and Li H: Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study. Oncol Lett 9: 1651-1656, 2015.
APA
Yu, J., Shi, W., Zhao, R., Gao, X., & Li, H. (2015). Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study. Oncology Letters, 9, 1651-1656. https://doi.org/10.3892/ol.2015.2943
MLA
Yu, J., Shi, W., Zhao, R., Gao, X., Li, H."Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study". Oncology Letters 9.4 (2015): 1651-1656.
Chicago
Yu, J., Shi, W., Zhao, R., Gao, X., Li, H."Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study". Oncology Letters 9, no. 4 (2015): 1651-1656. https://doi.org/10.3892/ol.2015.2943
Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Shi W, Zhao R, Gao X and Li H: Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study. Oncol Lett 9: 1651-1656, 2015.
APA
Yu, J., Shi, W., Zhao, R., Gao, X., & Li, H. (2015). Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study. Oncology Letters, 9, 1651-1656. https://doi.org/10.3892/ol.2015.2943
MLA
Yu, J., Shi, W., Zhao, R., Gao, X., Li, H."Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study". Oncology Letters 9.4 (2015): 1651-1656.
Chicago
Yu, J., Shi, W., Zhao, R., Gao, X., Li, H."Epidemiology of brain tumors in children aged two and under: A 10-year single-institute study". Oncology Letters 9, no. 4 (2015): 1651-1656. https://doi.org/10.3892/ol.2015.2943
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team