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Article

Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies

  • Authors:
    • Yan Zhao
    • Bingwei Wang
    • Kai Hu
    • Juan Wang
    • Su Lu
    • Yanxi Zhang
    • Weiquan Lu
    • Erjiang Zhao
    • Ling Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, Department of Social Medicine and Health Service Management, College of Public Health, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, Henan Academy of Medical Sciences, Zhengzhou, Henan 450003, P.R. China, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, P.R. China, Department of Radiotherapy, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China
  • Pages: 1947-1953
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    Published online on: February 10, 2015
       https://doi.org/10.3892/ol.2015.2948
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Abstract

The GSTT1 gene encodes a key enzyme involved in the metabolism of xenobiotics and its polymorphisms have been associated with individual susceptibility to various malignancies. Numerous molecular epidemiological studies have been performed to investigate the association between GSTT1 gene polymorphisms and lung cancer susceptibility; however, the results of previous studies were inconsistent. Therefore, the aim of the present study was to conduct a meta‑analysis in order to derive a more precise estimation of the association in the East Asian populations. The meta‑analysis included 7,415 lung cancer cases and 6,084 controls from 26 published studies in East Asia, which were selected from the PubMed and China National Knowledge Infrastructure databases, up to March 20, 2014. Using crude odds ratios (ORs) with 95% confidence intervals (CIs), a statistically significant association was identified between the GSTT1 null genotype and lung cancer in the East Asian populations (OR=1.17; 95% CI, 1.09‑1.25; Pheterogeneity=0.003). Furthermore, subgroup analyses revealed that the lung cancer risk in smokers carrying the GSTT1 null genotype was significantly increased compared with non‑smokers (OR=1.71; 95% CI, 1.04‑2.81; Pheterogeneity=0.002). Thus, the GSTT1 null genotype may increase the risk of lung cancer among the East Asian populations.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Wang B, Hu K, Wang J, Lu S, Zhang Y, Lu W, Zhao E and Yuan L: Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies. Oncol Lett 9: 1947-1953, 2015.
APA
Zhao, Y., Wang, B., Hu, K., Wang, J., Lu, S., Zhang, Y. ... Yuan, L. (2015). Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies. Oncology Letters, 9, 1947-1953. https://doi.org/10.3892/ol.2015.2948
MLA
Zhao, Y., Wang, B., Hu, K., Wang, J., Lu, S., Zhang, Y., Lu, W., Zhao, E., Yuan, L."Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies". Oncology Letters 9.4 (2015): 1947-1953.
Chicago
Zhao, Y., Wang, B., Hu, K., Wang, J., Lu, S., Zhang, Y., Lu, W., Zhao, E., Yuan, L."Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies". Oncology Letters 9, no. 4 (2015): 1947-1953. https://doi.org/10.3892/ol.2015.2948
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Wang B, Hu K, Wang J, Lu S, Zhang Y, Lu W, Zhao E and Yuan L: Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies. Oncol Lett 9: 1947-1953, 2015.
APA
Zhao, Y., Wang, B., Hu, K., Wang, J., Lu, S., Zhang, Y. ... Yuan, L. (2015). Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies. Oncology Letters, 9, 1947-1953. https://doi.org/10.3892/ol.2015.2948
MLA
Zhao, Y., Wang, B., Hu, K., Wang, J., Lu, S., Zhang, Y., Lu, W., Zhao, E., Yuan, L."Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies". Oncology Letters 9.4 (2015): 1947-1953.
Chicago
Zhao, Y., Wang, B., Hu, K., Wang, J., Lu, S., Zhang, Y., Lu, W., Zhao, E., Yuan, L."Glutathione S-transferase θ1 polymorphism contributes to lung cancer susceptibility: A meta-analysis of 26 case-control studies". Oncology Letters 9, no. 4 (2015): 1947-1953. https://doi.org/10.3892/ol.2015.2948
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