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Article

B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor

  • Authors:
    • Yupeng Yang
    • Ke Wu
    • Ende Zhao
    • Wei Li
    • Liang Shi
    • Gengchen Xie
    • Bin Jiang
    • Yaxin Wang
    • Ruidong Li
    • Peng Zhang
    • Xiaoming Shuai
    • Guobin Wang
    • Kaixiong Tao
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Anesthesiology and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Pages: 1833-1838
    |
    Published online on: February 10, 2015
       https://doi.org/10.3892/ol.2015.2949
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Abstract

Cancer stem‑like cells (CSCs) are a rare tumorigenic population with the ability to self‑renew in numerous cancer types. Their existence is considered a pivotal contributor to tumor recurrence. B7‑H1 is a ligand of inhibitory inducible co‑stimulator (ICOS) that is broadly expressed on various human cancers. ICOS acts as a ligand of programmed death‑1 (PD‑1) on T cells, induces the immune escape of cancer cells and also acts as a receptor mediating anti‑apoptotic effects on cancer cells. However, the expression and function of B7‑H1 on CSCs is not yet clear. In the present study, gastric cancer samples were collected and the B7‑H1 expression in gastric cancer CSCs was detected. Ki67, a proliferation marker, was found to be expressed at a higher rate in B7‑H1+ CSCs compared with the B7‑H1‑ counterparts. SGC‑7901 cells, a gastric cancer cell line, were cultured in serum‑free medium to form sphere cells that possessed stem cell characteristics and could express B7‑H1 with the stimulation of interferon‑γ. The proliferative ability of sphere cells was enhanced following B7‑H1 activation with recombinant PD‑1 in vivo and in vitro. This effect could be eliminated by neutralizing B7‑H1. Overall, B7‑H1 can act as a stimulating receptor for CSCs, and induce CSC proliferation. Blocking B7‑H1 on CSCs may possess therapeutic potential for treating gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Wu K, Zhao E, Li W, Shi L, Xie G, Jiang B, Wang Y, Li R, Zhang P, Zhang P, et al: B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor. Oncol Lett 9: 1833-1838, 2015.
APA
Yang, Y., Wu, K., Zhao, E., Li, W., Shi, L., Xie, G. ... Tao, K. (2015). B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor. Oncology Letters, 9, 1833-1838. https://doi.org/10.3892/ol.2015.2949
MLA
Yang, Y., Wu, K., Zhao, E., Li, W., Shi, L., Xie, G., Jiang, B., Wang, Y., Li, R., Zhang, P., Shuai, X., Wang, G., Tao, K."B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor". Oncology Letters 9.4 (2015): 1833-1838.
Chicago
Yang, Y., Wu, K., Zhao, E., Li, W., Shi, L., Xie, G., Jiang, B., Wang, Y., Li, R., Zhang, P., Shuai, X., Wang, G., Tao, K."B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor". Oncology Letters 9, no. 4 (2015): 1833-1838. https://doi.org/10.3892/ol.2015.2949
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Wu K, Zhao E, Li W, Shi L, Xie G, Jiang B, Wang Y, Li R, Zhang P, Zhang P, et al: B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor. Oncol Lett 9: 1833-1838, 2015.
APA
Yang, Y., Wu, K., Zhao, E., Li, W., Shi, L., Xie, G. ... Tao, K. (2015). B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor. Oncology Letters, 9, 1833-1838. https://doi.org/10.3892/ol.2015.2949
MLA
Yang, Y., Wu, K., Zhao, E., Li, W., Shi, L., Xie, G., Jiang, B., Wang, Y., Li, R., Zhang, P., Shuai, X., Wang, G., Tao, K."B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor". Oncology Letters 9.4 (2015): 1833-1838.
Chicago
Yang, Y., Wu, K., Zhao, E., Li, W., Shi, L., Xie, G., Jiang, B., Wang, Y., Li, R., Zhang, P., Shuai, X., Wang, G., Tao, K."B7-H1 enhances proliferation ability of gastric cancer stem-like cells as a receptor". Oncology Letters 9, no. 4 (2015): 1833-1838. https://doi.org/10.3892/ol.2015.2949
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