Primary central nervous system lymphoma mimicking recurrent depressive disorder: A case report

Liu,Weibo; Xue,Jing; Yu,Shaohua; Chen,Qiaozhen; Li,Xiuzhen; Yu,Risheng

doi:10.3892/ol.2015.2963

April-2015 Volume 9 Issue 4

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April-2015 Volume 9 Issue 4

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Case Report

Primary central nervous system lymphoma mimicking recurrent depressive disorder: A case report

Authors:
- Weibo Liu
- Jing Xue
- Shaohua Yu
- Qiaozhen Chen
- Xiuzhen Li
- Risheng Yu
View Affiliations / Copyright

Affiliations: Department of Psychiatry, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Rheumatology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Pathology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
Pages: 1819-1821
|
Published online on: February 13, 2015

https://doi.org/10.3892/ol.2015.2963
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Abstract

Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal non‑Hodgkin lymphoma, which is limited to the central nervous system. Few studies are available reporting psychiatric symptoms as the initial and dominant presentation of PCNSL. The current study reports the case of a PCNSL patient with a history of major depressive disorder and coexisting rheumatoid arthritis (treated with methotrexate), who initially presented with recurrent depressive disorder that showed no response to antidepressant drug therapy. Magnetic resonance imaging revealed multiple mass lesions in the brain, and pathological examination of the biopsy confirmed the diagnosis of diffuse large B cell lymphoma of the central nervous system. The present case demonstrated that PCNSL may affect mood in the early stages of the disease and thus, clinicians must be aware of this manifestation in patients with depressive disorder co‑existing with immunosuppressive conditions, as early detection and appropriate treatment are important prognostic factors for PCNSL.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary central nervous system lymphoma mimicking recurrent depressive disorder: A case report

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