Isolated primary intracranial myeloid sarcoma with neuromeningeal infiltration: A case report

Qian,Jun; Cui,Qu; Liu,Yuanbo; Li,Xiaoyan; Sun,Xuefei; Zhu,Hong; Wang,Chen

doi:10.3892/ol.2015.2964

April-2015 Volume 9 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

April-2015 Volume 9 Issue 4

Full Size Image

Case Report

Isolated primary intracranial myeloid sarcoma with neuromeningeal infiltration: A case report

Authors:
- Jun Qian
- Qu Cui
- Yuanbo Liu
- Xiaoyan Li
- Xuefei Sun
- Hong Zhu
- Chen Wang
View Affiliations / Copyright

Affiliations: Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Dongcheng, Beijing 100050, P.R. China, Department of Internal Medicine, Beijing Tiantan Hospital, Capital Medical University, Dongcheng, Beijing 100050, P.R. China
Pages: 1647-1650
|
Published online on: February 13, 2015

https://doi.org/10.3892/ol.2015.2964
Expand metrics +

Abstract

Myeloid sarcoma is a rare extramedullary malignant tumor, which is often accompanied by the development of systemic myeloid disease at various sites. The involvement of the central nervous system is uncommon and spinal cord compression is particularly rare. In November 2012, a 27-year-old male presented with a paroxysmal headache, accompanied by nausea and vomiting, which had persisted for one year, and eyesight deterioration that had been apparent for five months. Magnetic resonance imaging (MRI) indicated a space-occupying disorder, a craniotomy to resect the brain tumor was undertaken, the pathological diagnosis of which was myeloid sarcoma. Two months after receiving 40 Gy of radiotherapy, the patient experienced numbness of the right thigh. MRI of the lumbar spinal canal revealed a mass involved both inside and outside the lumbar spinal canal. Pathological examination of the mass following resection also indicated myeloid sarcoma. Immunohistochemical analysis was positive for the ETO fusion gene in the bone marrow. Following six cycles of chemotherapy treatment, the patient achieved complete remission. At present, the patient is stable and is attending follow‑up examinations regularly.

View Figures

View References

1	Campidelli C, Agostinelli C, Stitson R and Pileri SA: Myeloid sarcoma: extramedullary manifestation of myeloid disorders. Am J Clin Pathol. 132:426–437. 2009. View Article : Google Scholar : PubMed/NCBI
2	Pileri SA, Ascani S, Cox MC, et al: Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 21:340–350. 2007. View Article : Google Scholar
3	Kasahara S, Tsurumi H, Hara T, et al: Idiopathic myelofibrosis developing isolated granulocytic sarcoma with der (1;7)(q10; p10) after splenectomy and finally transforming to acute myelogenous leukemia. Leuk Lymphoma. 39:427–433. 2000. View Article : Google Scholar
4	Cankaya H, Ugras S and Dilek I: Head and neck granulocytic sarcoma with acute myeloid leukemia: three rare cases. Ear Nose Throat J. 80:224–226. 228–229. 2001.PubMed/NCBI
5	Suzer T, Colakoglu N, Cirak B, et al: Intracerebellar granulocytic sarcoma complicating acute myelogenous leukemia: a case report and review of the literature. J Clin Neurosci. 11:914–917. 2004. View Article : Google Scholar : PubMed/NCBI
6	Szomor A, Baranyai F, Tornóczky T and Losonczy H: Penile chloroma in a patient with secondary acute myeloid leukemia. Eur J Haematol. 68:3222002. View Article : Google Scholar : PubMed/NCBI
7	Imamura T, Matsuo S, Yoshihara T, et al: Granulocytic sarcoma presenting with severe adenopathy (cervical lymph nodes, tonsils, and adenoids) in a child with juvenile myelomonocytic leukemia and successful treatment with allogeneic bone marrow transplantation. Int J Hematol. 80:186–189. 2004. View Article : Google Scholar : PubMed/NCBI
8	Elenitoba-Johnson K, Hodges GF, King TC, et al: Extramedullary myeloid cell tumors arising in the setting of chronic myelomonocytic leukemia. A report of two cases. Arch Pathol Lab Med. 120:62–67. 1996.PubMed/NCBI
9	Tsimberidou AM, Kantarjian HM, Estey E, et al: Outcome in patients with nonleukemic granulocytic sarcoma treated with chemotherapy with or without radiotherapy. Leukemia. 17:1100–1103. 2003. View Article : Google Scholar : PubMed/NCBI
10	Barnett MJ and Zussman WV: Granulocytic sarcoma of the brain: a case report and review of the literature. Radiology. 160:223–225. 1986. View Article : Google Scholar : PubMed/NCBI
11	Widhalm G, Dietrich W, Müllauer L, et al: Myeloid sarcoma with multiple lesions of the central nervous system in a patient without leukemia. Case report. J Neurosurg. 105:916–919. 2006. View Article : Google Scholar
12	Paydas S, Zorludemir S and Ergin M: Granulocytic sarcoma: 32 cases and review of the literature. Leuk Lymphoma. 47:2527–2541. 2006. View Article : Google Scholar : PubMed/NCBI
13	Yamauchi K and Yasuda M: Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature. Cancer. 94:1739–1746. 2002. View Article : Google Scholar : PubMed/NCBI
14	Imrie KR, Kovacs MJ, Selby D, et al: Isolated chloroma: the effect of early antileukemic therapy. Ann Intern Med. 123:351–353. 1995. View Article : Google Scholar : PubMed/NCBI
15	Reinhardt D and Creutzig U: Isolated myelosarcoma in children - update and review. Leuk Lymphoma. 43:565–574. 2002. View Article : Google Scholar : PubMed/NCBI
16	Döhner H, Estey EH, Amadori S, et al; European LeukemiaNet. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 115:453–474. 2010. View Article : Google Scholar
17	Nishimura S, Kyuma Y, Kamijo A and Maruta A: Isolated recurrence of granulocytic sarcoma manifesting as extra- and intracranial masses - case report. Neurol Med Chir (Tokyo). 44:311–316. 2004. View Article : Google Scholar
18	Jafee E, Harris NL and Stein H: Pathology and genetics tumors of haematopoietc and lymphoid tissues. World Health Organization Classification of Tumors. IARC; Lyon, France: pp. 104–105. 2001
19	Bakst RL, Tallman MS, Douer D and Yahalom J: How I treat extramedullary acute myeloid leukemia. Blood. 118:3785–3793. 2011. View Article : Google Scholar : PubMed/NCBI
20	Vorsanova SG, Yurov YB and Iourov IY: Human interphase chromosomes: a review of available molecular cytogenetic technologies. Mol Cytogenet. 3:12010. View Article : Google Scholar : PubMed/NCBI
21	Antic D, Elezovic I, Milic N, et al: Is there a ‘gold’ standard treatment for patients with isolated myeloid sarcoma? Biomed Pharmacother. 67:72–77. 2013. View Article : Google Scholar
22	Bakst R, Wolden S and Yahalom J: Radiation therapy for chloroma (granulocytic sarcoma). Int J Radiat Oncol Biol Phys. 82:1816–1822. 2012. View Article : Google Scholar
23	Xiao RZ, Long ZJ, Xiong MJ, Wang WW and Lin DJ: Diagnosis and treatment of a patient with isolated spinal granulocytic sarcoma: A case report. Oncol Lett. 5:1229–1232. 2013.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Isolated primary intracranial myeloid sarcoma with neuromeningeal infiltration: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Related Articles