Heat shock protein 27 promotes cell proliferation through activator protein-1 in lung cancer

Zhang,Sai; Hu,Yangmin; Huang,Yuwen; Xu,Huimin; Wu,Gongxiong; Dai,Haibin

doi:10.3892/ol.2015.3073

Heat shock protein 27 promotes cell proliferation through activator protein-1 in lung cancer

Authors:
- Sai Zhang
- Yangmin Hu
- Yuwen Huang
- Huimin Xu
- Gongxiong Wu
- Haibin Dai
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Affiliations: Department of Thoracic Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Published online on: March 26, 2015 https://doi.org/10.3892/ol.2015.3073
Pages: 2572-2576

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Abstract

Heat shock protein 27 (HSP27) is an important regulator involved in the development of lung cancer. However, limited evidence exists concerning the underlying molecular mechanisms of its action. The results of the present study revealed that HSP27 was highly expressed in the lung cancer tissues of mice. In an in vitro model, the overexpression of HSP27 promoted cell proliferation, while HSP27 knockdown inhibited cell proliferation. HSP27 promoted cell proliferation in vitro by directly upregulating the expression of HSP27 target genes, which required the activation of the activator protein‑1 (AP‑1) signaling pathway. This was evaluated by the phosphorylation status of an important pathway component, c‑Jun in lung cancer tissue and cells. These results suggested that HSP27 has a promotional role in lung cancer, and therefore indicated a novel mechanism involving lung cancer cell proliferation, which may underlie poor responses to therapy. Therefore, HSP27 may be a suitable therapeutic target for the treatment of lung cancer.

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