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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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June-2015 Volume 9 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis

Retraction in: /10.3892/ol.2015.3620
  • Authors:
    • Yanbin Zhang
    • Can Wei
    • Junhua Xi
    • Zhiguo Tang
    • Chaozhao Liang

  • View Affiliations / Copyright

    Affiliations: Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China
  • Pages: 2809-2814
    |
    Published online on: March 26, 2015
       https://doi.org/10.3892/ol.2015.3075
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Abstract

The present study aimed to examine the relationship between mammalian target of rapamycin (mTOR) and glucose transporter 3 (Glut3) in the process of mTOR‑mediated oncogenic glycolysis and tumorigenesis. Western blot analysis and quantitative polymerase chain reaction were used to compare the expression of Glut3 in mouse embryonic fibroblasts (MEFs) null for tuberous sclerosis complex 2 (Tsc2‑/‑) and control Tsc2+/+ MEFs. In addition, the glycolytic rate was tested following siRNA‑mediated knockdown of Glut3 in Tsc2‑/‑ cells. To determine whether Glut3 depletion affects the ability of cells to form tumors in vivo. Tsc2‑/‑ MEFs infected shGlut3 and shControl were injected into nude mice subcutaneously. The present study demonstrated that the expression of Glut3 is controlled by mTOR in Tsc2‑/‑ cells and that downregulation of Glut3 reduced the glycolytic rate in Tsc2‑/‑ cells. cells. Further studies in nude mice demonstrated that reduced Glut3 expression levels reduced the tumorigenetic effect in cells with hyperactive mTOR complex 1 (mTORC1). The present study indicates for the first time that Glut3 is a downstream target of mTORC1 and that Glut3 is critical in mTORC1‑associated tumorigenesis. Therefore, Glut3 is a potential target for the treatment of diseases associated with dysregulated mTORC1 signaling.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Wei C, Xi J, Tang Z and Liang C: Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis Retraction in /10.3892/ol.2015.3620. Oncol Lett 9: 2809-2814, 2015.
APA
Zhang, Y., Wei, C., Xi, J., Tang, Z., & Liang, C. (2015). Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis Retraction in /10.3892/ol.2015.3620. Oncology Letters, 9, 2809-2814. https://doi.org/10.3892/ol.2015.3075
MLA
Zhang, Y., Wei, C., Xi, J., Tang, Z., Liang, C."Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis Retraction in /10.3892/ol.2015.3620". Oncology Letters 9.6 (2015): 2809-2814.
Chicago
Zhang, Y., Wei, C., Xi, J., Tang, Z., Liang, C."Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis Retraction in /10.3892/ol.2015.3620". Oncology Letters 9, no. 6 (2015): 2809-2814. https://doi.org/10.3892/ol.2015.3075
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Wei C, Xi J, Tang Z and Liang C: Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis Retraction in /10.3892/ol.2015.3620. Oncol Lett 9: 2809-2814, 2015.
APA
Zhang, Y., Wei, C., Xi, J., Tang, Z., & Liang, C. (2015). Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis Retraction in /10.3892/ol.2015.3620. Oncology Letters, 9, 2809-2814. https://doi.org/10.3892/ol.2015.3075
MLA
Zhang, Y., Wei, C., Xi, J., Tang, Z., Liang, C."Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis Retraction in /10.3892/ol.2015.3620". Oncology Letters 9.6 (2015): 2809-2814.
Chicago
Zhang, Y., Wei, C., Xi, J., Tang, Z., Liang, C."Glucose transporter 3 performs a critical role in mTOR-mediated oncogenic glycolysis and tumorigenesis Retraction in /10.3892/ol.2015.3620". Oncology Letters 9, no. 6 (2015): 2809-2814. https://doi.org/10.3892/ol.2015.3075
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