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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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June-2015 Volume 9 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small cell lung cancer

  • Authors:
    • Tengfei Chen
    • Chun Xu
    • Jun Chen
    • Cheng Ding
    • Zhenlei Xu
    • Chang Li
    • Jun Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou, Jiangsu 215006, P.R. China
  • Pages: 2639-2646
    |
    Published online on: March 27, 2015
       https://doi.org/10.3892/ol.2015.3080
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Abstract

MicroRNAs are proposed to serve vital functions in the regulation of tumor progression and invasion. However, the expression levels of miR‑203 in non‑small cell lung cancer (NSCLC) and its clinical significance remain unknown. In the present study, the association between B‑cell‑specific moloney murine leukemia virus insertion site 1 (Bmi1) and miR‑203 was investigated. miR‑203 was demonstrated to act as a tumor suppressor by regulating the expression of Bmi1. miR‑203 expression levels were downregulated in NSCLC tissues while Bmi1 expression was upregulated in NSCLC tissues and cell lines. Furthermore, downregulated Bmi1 or enhanced miR‑203 expression inhibited NSCLC cell proliferation and invasion in vitro. In addition, a dual‑luciferase reporter assay was performed, which identified Bmi1 as a novel target of miR‑203. In conclusion, the present study demonstrated that miR‑203 functions as a tumor suppressor and is important in inhibiting the proliferation of NSCLC cells through targeting Bmi1. These findings indicate that miR‑203 may be useful as a novel potential therapeutic target for NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Chen T, Xu C, Chen J, Ding C, Xu Z, Li C and Zhao J: MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small cell lung cancer. Oncol Lett 9: 2639-2646, 2015.
APA
Chen, T., Xu, C., Chen, J., Ding, C., Xu, Z., Li, C., & Zhao, J. (2015). MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small cell lung cancer. Oncology Letters, 9, 2639-2646. https://doi.org/10.3892/ol.2015.3080
MLA
Chen, T., Xu, C., Chen, J., Ding, C., Xu, Z., Li, C., Zhao, J."MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small cell lung cancer". Oncology Letters 9.6 (2015): 2639-2646.
Chicago
Chen, T., Xu, C., Chen, J., Ding, C., Xu, Z., Li, C., Zhao, J."MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small cell lung cancer". Oncology Letters 9, no. 6 (2015): 2639-2646. https://doi.org/10.3892/ol.2015.3080
Copy and paste a formatted citation
x
Spandidos Publications style
Chen T, Xu C, Chen J, Ding C, Xu Z, Li C and Zhao J: MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small cell lung cancer. Oncol Lett 9: 2639-2646, 2015.
APA
Chen, T., Xu, C., Chen, J., Ding, C., Xu, Z., Li, C., & Zhao, J. (2015). MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small cell lung cancer. Oncology Letters, 9, 2639-2646. https://doi.org/10.3892/ol.2015.3080
MLA
Chen, T., Xu, C., Chen, J., Ding, C., Xu, Z., Li, C., Zhao, J."MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small cell lung cancer". Oncology Letters 9.6 (2015): 2639-2646.
Chicago
Chen, T., Xu, C., Chen, J., Ding, C., Xu, Z., Li, C., Zhao, J."MicroRNA-203 inhibits cellular proliferation and invasion by targeting Bmi1 in non-small cell lung cancer". Oncology Letters 9, no. 6 (2015): 2639-2646. https://doi.org/10.3892/ol.2015.3080
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