Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2015 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2015 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Nipple-sparing mastectomy in breast cancer patients: The role of adjuvant radiotherapy (Review)

  • Authors:
    • Stefan Janssen
    • Edna Holz‑Sapra
    • Dirk Rades
    • Alexander Moser
    • Gabriela Studer
  • View Affiliations / Copyright

    Affiliations: Medical Practice for Radiotherapy and Radiation Oncology, Hannover, Germany, Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland, Department of Radiation Oncology, University of Luebeck, Luebeck, Germany, Department of Gynecology and Obstetrics, Nordstadt Hospital, Hannover, Germany
  • Pages: 2435-2441
    |
    Published online on: March 27, 2015
       https://doi.org/10.3892/ol.2015.3084
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to evaluate the role of adjuvant radiotherapy (RT) following nipple-sparing mastectomy (NSM) for patients with ductal carcinoma in situ and invasive breast cancer, based on the published literature. Currently, there is no standard for RT following NSM. NSM aims to spare the nipple areola complex (NAC) without compromising locoregional control. Long‑term follow‑up studies have begun to show promising results. A search of the English literature was performed using the Medline database and Cochrane central library, with the keywords ‘nipple/areola‑sparing mastectomy’, ‘whole skin mastectomy’ and ‘NAC preservation’. A total of 32 original studies with data on NSM in terms of locoregional control, NAC control, NAC necrosis and adjuvant RT were identified. The median locoregional and NAC recurrence rates were 3.2 and 1.4% (range, 0‑28.4% and 0‑3.7%), respectively. The volume of remaining breast tissue following NSM was reported inconsistently. In 15 studies, RT was not mentioned. In the remaining 17 studies, RT was administered in 0‑100% of patients. Only 7 studies provided detailed information regarding the use of adjuvant RT. Adjuvant thoracic wall irradiation was not used in certain studies, not even for locoregionally advanced tumors. Overall, NSM appears a feasible treatment without increased risk of locoregional recurrence for selected patients. The role of adjuvant RT following NSM requires further clarification. The decision regarding adjuvant RT must be made in interdisciplinary tumor boards and with consideration of the individual situation of the patient.
View Figures

Figure 1

View References

1 

Mallon P, Feron JG, Couturaud B, Fitoussi A, Lemasurier P, Guihard T, Cothier-Savay I and Reyal F: The role of nipple-sparing mastectomy in breast cancer: A comprehensive review of the literature. Plast Reconstr Surg. 131:969–984. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Tokin C, Weiss A, Wang-Rodriguez J and Blair SL: Oncologic safety of skin-sparing and nipple-sparing mastectomy: a discussion and review of the literature. Int J Surg Oncol. 2012:9218212012.PubMed/NCBI

3 

Gerber B, Krause A, Reimer T, Müller H, Küchenmeister I, Makovitzky J, Kundt G and Friese K: Skin-sparing mastectomy with conservation of the nipple-areola complex and autologous reconstruction is an oncologically safe procedure. Ann Surg. 238:120–127. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Coopey SB, Tang R, Lei L, Freer PE, Kansal K, Colwell AS, Gadd MA, Specht MC, Austen WG Jr and Smith BL: Increasing eligibility for nipple-sparing mastectomy. Ann Surg Oncol. 20:3218–3222. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Niemeyera M, Ettla J, Plattnera B, Schmida R, Müllerb D, Machensb HG, Kiechlea M and Paepkea S: Nipple-Sparing Mastectomy - Extended Indications and Limitations. Breast Care (Basel). 5:253–258. 2010.PubMed/NCBI

6 

Murthy V and Chamberlain RS: Defining a place for nipple sparing mastectomy in modern breast care: An evidence based review. Breast J. 19:571–581. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Chung AP and Sacchini V: Nipple-sparing mastectomy: Where are we now? Surg Oncol. 17:261–266. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Rusby JE, Smith BL and Gui GP: Nipple-sparing mastectomy. Br J Surg. 97:305–316. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Salani B, Riera R, Barrett J, Atallah AN and Bevilacqua JLB: Nipple- and areola-sparing mastectomy for the treatment of breast cancer. Cochrane Database of Systematic Reviews.

10 

Petit JY, Veronesi U, Lohsiriwat V, Rey P, Curigliano G, Martella S, Garusi C, et al: Nipple-sparing mastectomy - is it worth the risk? Nat Rev Clin Oncol. 8:742–747. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Niemeyer M, Paepke S, Schmid R, Plattner B, Müller D, Kiechle M, Garusi C, et al: Extended indications for nipple-sparing mastectomy. Breast J. 17:296–299. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Voltura AM, Tsangaris TN, Rosson GD, Jacobs LK, Flores JI, Singh NK, Argani P and Balch CM: Nipple-sparing mastectomy: Critical assessment of 51 procedures and implications for selection criteria. Ann Surg Oncol. 15:3396–3401. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Shi A, Wu D, Li X, Zhang S, Li S, Xu H, Xie H and Fan Z: Subcutaneous Nipple-Sparing Mastectomy and Immediate Breast Reconstruction. Breast Care (Basel). 7:131–136. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Harness JK, Vetter TS and Salibian AH: Areola and nipple-areola-sparing mastectomy for breast cancer treatment and risk reduction: Report of an initial experience in a community hospital setting. Ann Surg Oncol. 18:917–922. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Sakamoto N, Fukuma E, Higa K, Ozaki S, Sakamoto M, Abe S, Kurihara T and Tozaki M: Early results of an endoscopic nipple-sparing mastectomy for breast cancer. Indian J Surg Oncol. 1:232–239. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Fortunato L, Loreti A, Andrich R, Costarelli L, Amini M, Farina M, Santini E and Vitelli CE: When mastectomy is needed: Is the nipple-sparing procedure a new standard with very few contraindications? J Surg Oncol. 108:207–212. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Benediktsson KP and Perbeck L: Survival in breast cancer after nipple-sparing subcutaneous mastectomy and immediate reconstruction with implants: A prospective trial with 13 years median follow-up in 216 patients. Eur J Surg Oncol. 34:143–148. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Rulli A, Caracappa D, Barberini F, Boselli C, Cirocchi R, Castellani E, Noya G and Covarelli P: Oncologic reliability of nipple-sparing mastectomy for selected patients with breast cancer. In Vivo. 27:387–394. 2013.PubMed/NCBI

19 

Spear SL, Willey SC, Feldman ED, Cocilovo C, Sidawy M, Al-Attar A, Hannan C, Seiboth L and Nahabedian MY: Nipple-sparing mastectomy for prophylactic and therapeutic indications. Plast Reconstr Surg. 128:1005–1014. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Tancredi A, Ciuffreda L, Petito L, Natale F and Murgo R: Nipple-areola-complex sparing mastectomy: Five years of experience in a single centre. Updates Surg. 65:289–294. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Kim HJ, Park EH, Lim WS, Seo JY, Koh BS, Lee TJ, Eom JS, Lee SW, Son BH, Lee JW, et al: Nipple areola skin-sparing mastectomy with immediate transverse rectus abdominis musculocutaneous flap reconstruction is an oncologically safe procedure: A single center study. Ann Surg. 251:493–498. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Crowe JP, Patrick RJ, Yetman RJ and Djohan R: Nipple-sparing mastectomy update: One hundred forty-nine procedures and clinical outcomes. Arch Surg. 143:1106–1110; discussion 1110. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Sacchini V, Pinotti JA, Barros AC, Luini A, Pluchinotta A, Pinotti M, Boratto MG, Ricci MD, Ruiz CA, Nisida AC, et al: Nipple-sparing mastectomy for breast cancer and risk reduction: oncologic or technical problem? J Am Coll Surg. 203:704–714. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Stanec Z, Žic R, Budi S, Stanec S, Milanović R, Vlajčić Z, Roje Z, Rudman F, Martić K, Held R and Božo G: Skin and nipple-areola complex sparing mastectomy in breast cancer patients: 15-year experience. Ann Plast Surg. 73:485–491. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Boneti C, Yuen J, Santiago C, Diaz Z, Robertson Y, Korourian S, Westbrook KC, Henry-Tillman RS and Klimberg VS: Oncologic safety of nipple skin-sparing or total skin-sparing mastectomies with immediate reconstruction. J Am Coll Surg. 212:686–693; discussion 693–695. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Djohan R, Gage E, Gatherwright J, Pavri S, Firouz J, Bernard S and Yetman R: Patient satisfaction following nipple-sparing mastectomy and immediate breast reconstruction: An 8-year outcome study. Plast Reconstr Surg. 125:818–829. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Salibian AH, Harness JK and Mowlds DS: Inframammary approach to nipple-areola-sparing mastectomy. Plast Reconstr Surg. 132:700e–708e. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Moyer HR, Ghazi B, Daniel JR, Gasgarth R and Carlson GW: Nipple-sparing mastectomy: Technical aspects and aesthetic outcomes. Ann Plast Surg. 68:446–450. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Petit JY, Veronesi U, Orecchia R, Rey P, Martella S, Didier F, Viale G, Veronesi P, Luini A, Galimberti V, et al: Nipple sparing mastectomy with nipple areola intraoperative radiotherapy: One thousand and one cases of a five years experience at the European institute of oncology of Milan (EIO). Breast Cancer Res Treat. 117:333–338. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Stolier AJ and Levine EA: Reducing the risk of nipple necrosis: Technical observations in 340 nipple-sparing mastectomies. Breast J. 19:173–179. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Chen CM, Disa JJ, Sacchini V, Pusic AL, Mehrara BJ, Garcia-Etienne CA and Cordeiro PG: Nipple-sparing mastectomy and immediate tissue expander/implant breast reconstruction. Plast Reconstr Surg. 124:1772–80. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Carlson GW, Chu CK, Moyer HR, Duggal C and Losken A: Predictors of nipple ischemia after nipple sparing mastectomy. Breast J. 20:69–73. 2014. View Article : Google Scholar : PubMed/NCBI

33 

de Alcantara Filho P, Capko D, Barry JM, Morrow M, Pusic A and Sacchini VS: Nipple-sparing mastectomy for breast cancer and risk-reducing surgery: The Memorial Sloan-Kettering Cancer Center experience. Ann Surg Oncol. 18:3117–3122. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Burdge EC, Yuen J, Hardee M, Gadgil PV, Das C, Henry-Tillman R, Ochoa D, Korourian S and Suzanne Klimberg V: Nipple skin-sparing mastectomy is feasible for advanced disease. Ann Surg Oncol. 20:3294–3302. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Warren Peled A, Foster RD, Stover AC, Itakura K, Ewing CA, Alvarado M, Hwang ES and Esserman LJ: Outcomes after total skin-sparing mastectomy and immediate reconstruction in 657 breasts. Ann Surg Oncol. 19:3402–3409. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Babiera G and Simmons R: Nipple-areolar complex-sparing mastectomy: Feasibility, patient selection, and technique. Ann Surg Oncol. 17:(Suppl 3). 245–248. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Steen ST, Chung AP, Han SH, Vinstein AL, Yoon JL and Giuliano AE: Predicting nipple-areolar involvement using preoperative breast MRI and primary tumor characteristics. Ann Surg Oncol. 20:633–639. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Sakurai T, Zhang N, Suzuma T, Umemura T, Yoshimura G, Sakurai T and Yang Q: Long-term follow-up of nipple-sparing mastectomy without radiotherapy: A single center study at a Japanese institution. Med Oncol. 30:4812013. View Article : Google Scholar : PubMed/NCBI

39 

Munhoz AM, Aldrighi CM, Montag E, Arruda EG, Aldrighi JM, Gemperli R, Filassi JR and Ferreira MC: Clinical outcomes following nipple-areola-sparing mastectomy with immediate implant-based breast reconstruction: A 12-year experience with an analysis of patient and breast-related factors for complications. Breast Cancer Res Treat. 140:545–555. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Paepke S, Schmid R, Fleckner S, Paepke D, Niemeyer M, Schmalfeldt B, Jacobs VR and Kiechle M: Subcutaneous mastectomy with conservation of the nipple-areola skin: Broadening the indications. Ann Surg. 250:288–292. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Algaithy ZK, Petit JY, Lohsiriwat V, Maisonneuve P, Rey PC, Baros N, Lai H, Mulas P, Barbalho DM, Veronesi P and Rietjens M: Nipple sparing mastectomy: can we predict the factors predisposing to necrosis? Eur J Surg Oncol. 38:125–129. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Petit JY, Veronesi U, Orecchia R, Rey P, Didier F, Giraldo A, Luini A, De Lorenzi F, Rietjens M, Garusi C, et al: The nipple-sparing mastectomy: Early results of a feasibility study of a new application of perioperative radiotherapy (ELIOT) in the treatment of breast cancer when mastectomy is indicated. Tumori. 89:288–291. 2003.PubMed/NCBI

43 

Gould DJ, Hunt KK, Liu J, Kuerer HM, Crosby MA, Babiera G and Kronowitz SJ: Impact of surgical techniques, biomaterials, and patient variables on rate of nipple necrosis after nipple-sparing mastectomy. Plast Reconstr Surg. 132:330e–338e. 2013. View Article : Google Scholar : PubMed/NCBI

44 

National Comprehensive Cancer Network (NCCN), . Practical Guidlines in Oncology-Breast Cancer-. Version 1. 2014.

45 

Interdisciplinary S3 Guidelines for the Diagnosis, . Treatment and Follow-up Care of Breast Cancer. Version 3. 2012.http://www.awmf.org/uploads/tx_szleitlinien/032-045OL_k_S3__Brustkrebs_Mammakarzinom_Diagnostik_Therapie_Nachsorge_2012-07.pdf[(In German)].

46 

Senkus E, Kyriakides S, Penault-Llorca F, Poortmans P, Thompson A, Zackrisson S and Cardoso F: Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 24 Suppl 6:vi7–vi23. 2013.PubMed/NCBIPubMed/NCBI

47 

Komorowski AL, Zanini V, Regolo L, Carolei A, Wysocki WM and Costa A: Necrotic complications after nipple- and areola-sparing mastectomy. World J Surg. 30:1410–1413. 2006. View Article : Google Scholar : PubMed/NCBI

48 

EBCTCG (Early Breast Cancer Trialists' Collaborative Group), . McGale P, Taylor C, Correa C, et al: Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet. 383:2127–2135. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Caruso F, Ferrara M, Castiglione G, Trombetta G, De Meo L, Catanuto G and Carillio G: Nipple sparing subcutaneous mastectomy: Sixty-six months follow-up. Eur J Surg Oncol. 32:937–940. 2006. View Article : Google Scholar : PubMed/NCBI

50 

Smith BD, Arthur DW, Buchholz TA, Haffty BG, Hahn CA, Hardenbergh PH, Julian TB, Marks LB, Todor DA, Vicini FA, et al: Accelerated partial breast irradiation consensus statement from the American Society for Radiation Oncology (ASTRO). Int J Radiat Oncol Biol Phys. 74:987–1001. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Polgár C, Fodor J, Major T, Németh G, Lövey K, Orosz Z, Sulyok Z, Takácsi-Nagy Z and Kásler M: Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast carcinoma - 5-year results of a randomized trial. Int J Radiat Oncol Biol Phys. 69:694–702. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Janssen S, Holz‑Sapra E, Rades D, Moser A and Studer G: Nipple-sparing mastectomy in breast cancer patients: The role of adjuvant radiotherapy (Review). Oncol Lett 9: 2435-2441, 2015.
APA
Janssen, S., Holz‑Sapra, E., Rades, D., Moser, A., & Studer, G. (2015). Nipple-sparing mastectomy in breast cancer patients: The role of adjuvant radiotherapy (Review). Oncology Letters, 9, 2435-2441. https://doi.org/10.3892/ol.2015.3084
MLA
Janssen, S., Holz‑Sapra, E., Rades, D., Moser, A., Studer, G."Nipple-sparing mastectomy in breast cancer patients: The role of adjuvant radiotherapy (Review)". Oncology Letters 9.6 (2015): 2435-2441.
Chicago
Janssen, S., Holz‑Sapra, E., Rades, D., Moser, A., Studer, G."Nipple-sparing mastectomy in breast cancer patients: The role of adjuvant radiotherapy (Review)". Oncology Letters 9, no. 6 (2015): 2435-2441. https://doi.org/10.3892/ol.2015.3084
Copy and paste a formatted citation
x
Spandidos Publications style
Janssen S, Holz‑Sapra E, Rades D, Moser A and Studer G: Nipple-sparing mastectomy in breast cancer patients: The role of adjuvant radiotherapy (Review). Oncol Lett 9: 2435-2441, 2015.
APA
Janssen, S., Holz‑Sapra, E., Rades, D., Moser, A., & Studer, G. (2015). Nipple-sparing mastectomy in breast cancer patients: The role of adjuvant radiotherapy (Review). Oncology Letters, 9, 2435-2441. https://doi.org/10.3892/ol.2015.3084
MLA
Janssen, S., Holz‑Sapra, E., Rades, D., Moser, A., Studer, G."Nipple-sparing mastectomy in breast cancer patients: The role of adjuvant radiotherapy (Review)". Oncology Letters 9.6 (2015): 2435-2441.
Chicago
Janssen, S., Holz‑Sapra, E., Rades, D., Moser, A., Studer, G."Nipple-sparing mastectomy in breast cancer patients: The role of adjuvant radiotherapy (Review)". Oncology Letters 9, no. 6 (2015): 2435-2441. https://doi.org/10.3892/ol.2015.3084
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team