Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2015 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2015 Volume 9 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development

  • Authors:
    • Xiao‑Xue Ke
    • Dunke Zhang
    • Hailong Zhao
    • Renjian Hu
    • Zhen Dong
    • Rui Yang
    • Shunqin Zhu
    • Qingyou Xia
    • Han‑Fei Ding
    • Hongjuan Cui
  • View Affiliations / Copyright

    Affiliations: Cell Biology Laboratory, State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, P.R. China, Department of Pharmaceutical Engineering, School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing 400050, P.R. China, Department of Biochemistry and Molecular Biology, Cancer Center, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA
    Copyright: © Ke et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2507-2514
    |
    Published online on: March 31, 2015
       https://doi.org/10.3892/ol.2015.3088
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Neuroblastoma is the one of the most common extracranial childhood malignancies, accounting for ~15% of tumor‑associated deaths in children. It is generally considered that neuroblastoma originates from neural crest cells in the paravertebral sympathetic ganglia and the adrenal medulla. However, the mechanism by which neuroblastoma arises during sympathetic neurogenesis and the cellular mechanism that drives neuroblastoma development remains unclear. The present study investigated the cell components during neuroblastoma development in the tyrosine hydroxylase‑v‑myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (TH‑MYCN) mouse model, a transgenic mouse model of human neuroblastoma. The present study demonstrates that paired‑like homeobox 2b (Phox2B)+ neuronal progenitors are the major cellular population in hyperplastic lesions and primary tumors. In addition, Phox2B+ neuronal progenitors in hyperplastic lesions or primary tumors were observed to be in an actively proliferative and undifferentiated state. The current study also demonstrated that high expression levels of Phox2B promotes neuroblastoma cell proliferation and xenograft tumor growth. These findings indicate that the proliferation of undifferentiated Phox2B+ neuronal progenitors is a cellular mechanism that promotes neuroblastoma development and indicates that Phox2B is a critical regulator in neuroblastoma pathogenesis.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Hsieh MH, Meng MV, Walsh TJ, Matthay KK and Baskin LS: Increasing incidence of neuroblastoma and potentially higher associated mortality of children from nonmetropolitan areas: analysis of the surveillance, epidemiology, and end results database. J Pediatr Hematol Oncol. 31:942–946. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Brodeur GM: Neuroblastoma: biological insights into a clinical enigma. Nat Rev Cancer. 3:203–216. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Baker CV and Bronner-Fraser M: The origins of the neural crest. Part I: embryonic induction. Mech Dev. 69:3–11. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Mayor R and Theveneau E: The neural crest. Development. 140:2247–2251. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Anderson DJ: Molecular control of cell fate in the neural crest: the sympathoadrenal lineage. Annu Rev Neurosci. 16:129–158. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Unsicker K: The chromaffin cell: paradigm in cell, developmental and growth factor biology. J Anat. 183:207–221. 1993.PubMed/NCBI

7 

Sano H, Bonadio J, Gerbing RB, et al: International neuroblastoma pathology classification adds independent prognostic information beyond the prognostic contribution of age. Eur J Cancer. 42:1113–1119. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Shimada H, Ambros IM, Dehner LP, et al: The International Neuroblastoma Pathology Classification (the Shimada system). Cancer. 86:364–372. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Tsarovina K, Schellenberger J, Schneider C and Rohrer H: Progenitor cell maintenance and neurogenesis in sympathetic ganglia involves Notch signaling. Mol Cell Neurosci. 37:20–31. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Shah NM, Groves AK and Anderson DJ: Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Cell. 85:331–343. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Reissmann E, Ernsberger U, Francis-West PH, Rueger D, Brickell PM and Rohrer H: Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons. Development. 122:2079–2088. 1996.PubMed/NCBI

12 

Vincentz JW, VanDusen NJ, Fleming AB, et al: A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis. J Neurosci. 32:2110–2120. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Hirsch MR, Tiveron MC, Guillemot F, Brunet JF and Goridis C: Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development. 125:599–608. 1998.PubMed/NCBI

14 

Lo L, Tiveron MC and Anderson DJ: MASH1 activates expression of the paired homeodomain transcription factor Phox2a, and couples pan-neuronal and subtype-specific components of autonomic neuronal identity. Development. 125:609–620. 1998.PubMed/NCBI

15 

Stanke M, Junghans D, Geissen M, Goridis C, Ernsberger U and Rohrer H: The Phox2 homeodomain proteins are sufficient to promote the development of sympathetic neurons. Development. 126:4087–4094. 1999.PubMed/NCBI

16 

Tsarovina K, Pattyn A, Stubbusch J, et al: Essential role of Gata transcription factors in sympathetic neuron development. Development. 131:4775–4786. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Pattyn A, Morin X, Cremer H, Goridis C and Brunet JF: The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature. 399:366–370. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Lim KC, Lakshmanan G, Crawford SE, Gu Y, Grosveld F and Engel JD: Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system. Nat Genet. 25:209–212. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Schneider C, Wicht H, Enderich J, Wegner M and Rohrer H: Bone morphogenetic proteins are required in vivo for the generation of sympathetic neurons. Neuron. 24:861–870. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Dyer MA: Mouse models of childhood cancer of the nervous system. J Clin Pathol. 57:561–576. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Seeger RC, Brodeur GM, Sather H, et al: Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med. 313:1111–1116. 1985. View Article : Google Scholar : PubMed/NCBI

22 

Maris JM and Matthay KK: Molecular biology of neuroblastoma. J Clin Oncol. 17:2264–2279. 1999.PubMed/NCBI

23 

Cohn SL, Pearson AD, London WB, et al: INRG Task Force: The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J Clin Oncol. 27:289–297. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Weiss WA, Aldape K, Mohapatra G, Feuerstein BG and Bishop JM: Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J. 16:2985–2995. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Hansford LM, Thomas WD, Keating JM, et al: Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. Proc Natl Acad Sci USA. 101:12664–12669. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Muñoz-Velasco I, Ortíz R, Echeverría OM, Escobar ML and Vázquez-Nin GH: Characterization of the pre-meiotic S phase through incorporation of BrdU during spermatogenesis in the rat. J Histochem Cytochem. 61:680–689. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Pathmanathan N and Balleine RL: Ki67 and proliferation in breast cancer. J Clin Pathol. 66:512–516. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Dubreuil V, Hirsch MR, Jouve C, Brunet JF and Goridis C: The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis. Development. 129:5241–5253. 2002.PubMed/NCBI

29 

Shimada H, Stram DO, Chatten J, et al: Identification of subsets of neuroblastomas by combined histopathologic and N-myc analysis. J Natl Cancer Inst. 87:1470–1476. 1995. View Article : Google Scholar : PubMed/NCBI

30 

Egawa C and Kameda Y: Innervation of the chicken parathyroid glands: immunohistochemical study with the TuJ1, galanin, VIP, substance P, CGRP and tyrosine hydroxylase antibodies. Anat Embryol (Berl). 191:445–450. 1995. View Article : Google Scholar : PubMed/NCBI

31 

Sommer L, Shah N, Rao M and Anderson DJ: The cellular function of MASH1 in autonomic neurogenesis. Neuron. 15:1245–1258. 1995. View Article : Google Scholar : PubMed/NCBI

32 

Maris JM, Hogarty MD, Bagatell R and Cohn SL: Neuroblastoma. Lancet. 369:2106–2120. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Huang M and Weiss WA: Neuroblastoma and MYCN. Cold Spring Harb Perspect Med. 3:a0144152013. View Article : Google Scholar : PubMed/NCBI

34 

Adhikary S and Eilers M: Transcriptional regulation and transformation by Myc proteins. Nat Rev Mol Cell Biol. 6:635–645. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Hipp NI, Christner L, Wirth T, et al: MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts. Carcinogenesis. 35:479–488. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Brodeur GM and Seeger RC: Gene amplification in human neuroblastomas: basic mechanisms and clinical implications. Cancer Genet Cytogenet. 19:101–111. 1986. View Article : Google Scholar : PubMed/NCBI

37 

Bourdeaut F, Trochet D, Janoueix-Lerosey I, et al: Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma. Cancer Lett. 228:51–58. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ke XX, Zhang D, Zhao H, Hu R, Dong Z, Yang R, Zhu S, Xia Q, Ding HF, Cui H, Cui H, et al: Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development. Oncol Lett 9: 2507-2514, 2015.
APA
Ke, X., Zhang, D., Zhao, H., Hu, R., Dong, Z., Yang, R. ... Cui, H. (2015). Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development. Oncology Letters, 9, 2507-2514. https://doi.org/10.3892/ol.2015.3088
MLA
Ke, X., Zhang, D., Zhao, H., Hu, R., Dong, Z., Yang, R., Zhu, S., Xia, Q., Ding, H., Cui, H."Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development". Oncology Letters 9.6 (2015): 2507-2514.
Chicago
Ke, X., Zhang, D., Zhao, H., Hu, R., Dong, Z., Yang, R., Zhu, S., Xia, Q., Ding, H., Cui, H."Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development". Oncology Letters 9, no. 6 (2015): 2507-2514. https://doi.org/10.3892/ol.2015.3088
Copy and paste a formatted citation
x
Spandidos Publications style
Ke XX, Zhang D, Zhao H, Hu R, Dong Z, Yang R, Zhu S, Xia Q, Ding HF, Cui H, Cui H, et al: Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development. Oncol Lett 9: 2507-2514, 2015.
APA
Ke, X., Zhang, D., Zhao, H., Hu, R., Dong, Z., Yang, R. ... Cui, H. (2015). Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development. Oncology Letters, 9, 2507-2514. https://doi.org/10.3892/ol.2015.3088
MLA
Ke, X., Zhang, D., Zhao, H., Hu, R., Dong, Z., Yang, R., Zhu, S., Xia, Q., Ding, H., Cui, H."Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development". Oncology Letters 9.6 (2015): 2507-2514.
Chicago
Ke, X., Zhang, D., Zhao, H., Hu, R., Dong, Z., Yang, R., Zhu, S., Xia, Q., Ding, H., Cui, H."Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development". Oncology Letters 9, no. 6 (2015): 2507-2514. https://doi.org/10.3892/ol.2015.3088
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team