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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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June-2015 Volume 9 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Case Report

Advanced squamous lung carcinoma in a patient experiencing long-term survival following repeated responses to gemcitabine and cisplatin chemotherapy: A case report

  • Authors:
    • Min Yu
    • Shuang Zhang
    • Yanying Li
    • Zhenyu Ding
    • Feng Peng
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
  • Pages: 2874-2878
    |
    Published online on: April 2, 2015
       https://doi.org/10.3892/ol.2015.3097
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Abstract

The cisplatin and gemcitabine regimen is one of the most effective regimens against advanced non-small-cell lung cancer. However, tumors that are initially sensitive to chemotherapy treatment may acquire drug resistance. Excision repair cross complementation 1 gene (ERCC1) is involved in the repair of DNA damage caused by cisplatin, and ribonucleotide reductase M1 subunit (RRM1) is associated with gemcitabine resistance in tumor cells. The current study reports the case of a patient with advanced squamous cell lung carcinoma exhibiting low ERCC1 and RRM1 expression levels, who experienced long‑term survival following repeated responses to gemcitabine and cisplatin chemotherapy. This case indicates that selected patients may benefit from multiple courses of gemcitabine and cisplatin chemotherapy, and the sustained clinical benefits suggest that further investigation into individualized therapy is merited.
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Copy and paste a formatted citation
Spandidos Publications style
Yu M, Zhang S, Li Y, Ding Z and Peng F: Advanced squamous lung carcinoma in a patient experiencing long-term survival following repeated responses to gemcitabine and cisplatin chemotherapy: A case report. Oncol Lett 9: 2874-2878, 2015.
APA
Yu, M., Zhang, S., Li, Y., Ding, Z., & Peng, F. (2015). Advanced squamous lung carcinoma in a patient experiencing long-term survival following repeated responses to gemcitabine and cisplatin chemotherapy: A case report. Oncology Letters, 9, 2874-2878. https://doi.org/10.3892/ol.2015.3097
MLA
Yu, M., Zhang, S., Li, Y., Ding, Z., Peng, F."Advanced squamous lung carcinoma in a patient experiencing long-term survival following repeated responses to gemcitabine and cisplatin chemotherapy: A case report". Oncology Letters 9.6 (2015): 2874-2878.
Chicago
Yu, M., Zhang, S., Li, Y., Ding, Z., Peng, F."Advanced squamous lung carcinoma in a patient experiencing long-term survival following repeated responses to gemcitabine and cisplatin chemotherapy: A case report". Oncology Letters 9, no. 6 (2015): 2874-2878. https://doi.org/10.3892/ol.2015.3097
Copy and paste a formatted citation
x
Spandidos Publications style
Yu M, Zhang S, Li Y, Ding Z and Peng F: Advanced squamous lung carcinoma in a patient experiencing long-term survival following repeated responses to gemcitabine and cisplatin chemotherapy: A case report. Oncol Lett 9: 2874-2878, 2015.
APA
Yu, M., Zhang, S., Li, Y., Ding, Z., & Peng, F. (2015). Advanced squamous lung carcinoma in a patient experiencing long-term survival following repeated responses to gemcitabine and cisplatin chemotherapy: A case report. Oncology Letters, 9, 2874-2878. https://doi.org/10.3892/ol.2015.3097
MLA
Yu, M., Zhang, S., Li, Y., Ding, Z., Peng, F."Advanced squamous lung carcinoma in a patient experiencing long-term survival following repeated responses to gemcitabine and cisplatin chemotherapy: A case report". Oncology Letters 9.6 (2015): 2874-2878.
Chicago
Yu, M., Zhang, S., Li, Y., Ding, Z., Peng, F."Advanced squamous lung carcinoma in a patient experiencing long-term survival following repeated responses to gemcitabine and cisplatin chemotherapy: A case report". Oncology Letters 9, no. 6 (2015): 2874-2878. https://doi.org/10.3892/ol.2015.3097
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