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Article

Doxorubicin activates the Notch signaling pathway in osteosarcoma

  • Authors:
    • Hongjun Mei
    • Ling Yu
    • Peng Ji
    • Jian Yang
    • Shuo Fang
    • Weichun Guo
    • Yang Liu
    • Xuanyin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Orthopaedics, Fifth Hospital of Wuhan, Hubei 430050, P.R. China, Department of Orthopaedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 2905-2909
    |
    Published online on: April 21, 2015
       https://doi.org/10.3892/ol.2015.3135
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Abstract

Notch signaling is critical in various biological processes, including cell proliferation, differentiation and apoptosis. Furthermore, accumulating evidence indicated that aberrant Notch signaling has a tumor‑promoting function in osteosarcoma. However, the effect of the conventional chemotherapeutic agent, doxorubicin, on Notch signaling remains unclear. In the present study, osteosarcoma cells were treated with various concentrations of doxorubicin and the effect on Notch signaling was analyzed. A cytostatic dose of doxorubicin (<0.5 µM) was identified to significantly activate the Notch signaling pathway in a dose‑dependent manner (P<0.01), as demonstrated by the elevated expression levels of Notch target genes. However, a toxic dose of doxorubicin (≥0.5 µM) significantly inhibited the Notch signaling pathway (P<0.01). These results indicated a significant correlation between doxorubicin administration and the Notch signaling pathway. Therefore, the present study supports further investigation into Notch and osteosarcoma chemoresistance.
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Copy and paste a formatted citation
Spandidos Publications style
Mei H, Yu L, Ji P, Yang J, Fang S, Guo W, Liu Y and Chen X: Doxorubicin activates the Notch signaling pathway in osteosarcoma. Oncol Lett 9: 2905-2909, 2015.
APA
Mei, H., Yu, L., Ji, P., Yang, J., Fang, S., Guo, W. ... Chen, X. (2015). Doxorubicin activates the Notch signaling pathway in osteosarcoma. Oncology Letters, 9, 2905-2909. https://doi.org/10.3892/ol.2015.3135
MLA
Mei, H., Yu, L., Ji, P., Yang, J., Fang, S., Guo, W., Liu, Y., Chen, X."Doxorubicin activates the Notch signaling pathway in osteosarcoma". Oncology Letters 9.6 (2015): 2905-2909.
Chicago
Mei, H., Yu, L., Ji, P., Yang, J., Fang, S., Guo, W., Liu, Y., Chen, X."Doxorubicin activates the Notch signaling pathway in osteosarcoma". Oncology Letters 9, no. 6 (2015): 2905-2909. https://doi.org/10.3892/ol.2015.3135
Copy and paste a formatted citation
x
Spandidos Publications style
Mei H, Yu L, Ji P, Yang J, Fang S, Guo W, Liu Y and Chen X: Doxorubicin activates the Notch signaling pathway in osteosarcoma. Oncol Lett 9: 2905-2909, 2015.
APA
Mei, H., Yu, L., Ji, P., Yang, J., Fang, S., Guo, W. ... Chen, X. (2015). Doxorubicin activates the Notch signaling pathway in osteosarcoma. Oncology Letters, 9, 2905-2909. https://doi.org/10.3892/ol.2015.3135
MLA
Mei, H., Yu, L., Ji, P., Yang, J., Fang, S., Guo, W., Liu, Y., Chen, X."Doxorubicin activates the Notch signaling pathway in osteosarcoma". Oncology Letters 9.6 (2015): 2905-2909.
Chicago
Mei, H., Yu, L., Ji, P., Yang, J., Fang, S., Guo, W., Liu, Y., Chen, X."Doxorubicin activates the Notch signaling pathway in osteosarcoma". Oncology Letters 9, no. 6 (2015): 2905-2909. https://doi.org/10.3892/ol.2015.3135
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