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Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma

  • Authors:
    • Yi Yu
    • Wei Wang
    • Lei Song
    • Wentao Hu
    • Chi Dong
    • Hailong Pei
    • Guangming Zhou
    • Zhongjin Yue
  • View Affiliations / Copyright

    Affiliations: Department of Urological Surgery, Key Laboratory of Urinary Diseases of Gansu Province, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R. China, Department of Space Radiobiology, Key Laboratory of Heavy Ion Radiation Biology and Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, P.R. China, Department of Pathology, Second Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2485-2494
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    Published online on: April 23, 2015
       https://doi.org/10.3892/ol.2015.3138
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Abstract

Renal cell carcinoma (RCC) is a common tissue tumor that occurs across all age groups and has become one of the types of cancer with the fastest increasing incidence. Due to the resistance of RCC chemo‑ and radiotherapy, surgery is the only currently effective treatment. Therefore, specific markers for the diagnosis and prognosis of RCC are expected to result in novel methods of treatment. Ecto‑5'‑nucleotidase, also termed cluster of differentiation (CD)73, is a protein that is activated in several types of aggressive cancer and may promote cancer progression. CD73 was examined in the present study to determine the association between the protein and RCC. The expression levels of CD73 in 159 RCC tissue sections and 30 paratumorous normal renal tissue samples obtained from 235 patients that underwent nephrectomy were examined by immunohistochemical staining. By contrast, the expression level of P‑glycoprotein (P‑gp), a potential prognostic factor in RCC, was also examined in 85 RCC and 13 normal tissue samples. Intense CD73 expression was identified in 75 out of 159 RCC cell membranes compared with normal renal tissues. In contrast, there was high P‑gp expression in the blood vessels of 42 out of 85 RCC tissues and there was no significant difference between the P‑gp expression identified in RCC cells (34 out of 85) and the cell membrane of normal renal cells (2 out of 13). The expression level of CD73 in RCC cells was significantly associated with tumor type, tumor node metastasis (TNM) stage, and tumor grade. However, the expression of P‑gp in RCC cells was only associated with the TNM stage and tumor grade. Using a multivariable Cox regression analysis, it was found that the median survival rate of RCC patients with intense CD73 expression in RCC cells was 62.06±5.35 months, which was drastically shorter compared with rare CD73 expression (103.72±3.67 months). In conclusion, the expression level of CD73 is significantly associated with RCC tumor progression and may serve as a favorable marker for the diagnosis and prognosis of RCC, in addition to being a therapeutic target for the treatment of RCC.
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Copy and paste a formatted citation
Spandidos Publications style
Yu Y, Wang W, Song L, Hu W, Dong C, Pei H, Zhou G and Yue Z: Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma. Oncol Lett 9: 2485-2494, 2015.
APA
Yu, Y., Wang, W., Song, L., Hu, W., Dong, C., Pei, H. ... Yue, Z. (2015). Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma. Oncology Letters, 9, 2485-2494. https://doi.org/10.3892/ol.2015.3138
MLA
Yu, Y., Wang, W., Song, L., Hu, W., Dong, C., Pei, H., Zhou, G., Yue, Z."Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma". Oncology Letters 9.6 (2015): 2485-2494.
Chicago
Yu, Y., Wang, W., Song, L., Hu, W., Dong, C., Pei, H., Zhou, G., Yue, Z."Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma". Oncology Letters 9, no. 6 (2015): 2485-2494. https://doi.org/10.3892/ol.2015.3138
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Y, Wang W, Song L, Hu W, Dong C, Pei H, Zhou G and Yue Z: Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma. Oncol Lett 9: 2485-2494, 2015.
APA
Yu, Y., Wang, W., Song, L., Hu, W., Dong, C., Pei, H. ... Yue, Z. (2015). Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma. Oncology Letters, 9, 2485-2494. https://doi.org/10.3892/ol.2015.3138
MLA
Yu, Y., Wang, W., Song, L., Hu, W., Dong, C., Pei, H., Zhou, G., Yue, Z."Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma". Oncology Letters 9.6 (2015): 2485-2494.
Chicago
Yu, Y., Wang, W., Song, L., Hu, W., Dong, C., Pei, H., Zhou, G., Yue, Z."Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma". Oncology Letters 9, no. 6 (2015): 2485-2494. https://doi.org/10.3892/ol.2015.3138
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