Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

  • Authors:
    • Hui Cheng
    • Cheng Chen
    • Lu Liu
    • Na Zhan
    • Benhui Li
  • View Affiliations

  • Published online on: April 23, 2015     https://doi.org/10.3892/ol.2015.3146
  • Pages: 2847-2853
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Esophageal squamous cell carcinoma (SCC) possesses one of the worst prognoses out of the digestive carcinomas. Several studies have suggested that transforming growth factor β receptor type II (TGF-βRII), Smad family member 4 (Smad4) and p21 wild‑type p53‑activated factor 1 (p21waf1) are associated with esophageal SCC. The aim of the present study was to evaluate the effect of Smad4, TGF‑βRII and p21waf1 in esophageal squamous cancer tissue and the pathological significance of the effect. An immunohistochemical method was used to evaluate the expression levels of Smad4, TGF‑βRII and p21waf1 in specimens of esophageal SCC lesions obtained from 80 patients. It was found that the expression of Smad4, TGF‑βRII and p21waf1 in histologically‑classified grade I esophageal SCC, without invasion or lymph node metastasis, was markedly higher compared with grade III esophageal SCC that had invaded into the deep muscular or serous layer and metastasized to the lymph nodes (P<0.05). Analysis of the expression level of Smad4, TGF‑βRII and p21waf1, as well as the clinical and pathological characteristics of esophageal SCC, revealed that the three proteins may be associated with the carcinogenesis, biological behavior and prognosis of esophageal SCC, parallel to the pathological stage and cell grade.
View Figures
View References

Related Articles

Journal Cover

June-2015
Volume 9 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cheng H, Chen C, Liu L, Zhan N and Li B: Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue. Oncol Lett 9: 2847-2853, 2015
APA
Cheng, H., Chen, C., Liu, L., Zhan, N., & Li, B. (2015). Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue. Oncology Letters, 9, 2847-2853. https://doi.org/10.3892/ol.2015.3146
MLA
Cheng, H., Chen, C., Liu, L., Zhan, N., Li, B."Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue". Oncology Letters 9.6 (2015): 2847-2853.
Chicago
Cheng, H., Chen, C., Liu, L., Zhan, N., Li, B."Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue". Oncology Letters 9, no. 6 (2015): 2847-2853. https://doi.org/10.3892/ol.2015.3146