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Article

Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue

  • Authors:
    • Hui Cheng
    • Cheng Chen
    • Lu Liu
    • Na Zhan
    • Benhui Li
  • View Affiliations / Copyright

    Affiliations: Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Radiotherapy, Hubei Provincial Tumor Hospital, Wuhan, Hubei 430060, P.R. China
  • Pages: 2847-2853
    |
    Published online on: April 23, 2015
       https://doi.org/10.3892/ol.2015.3146
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Abstract

Esophageal squamous cell carcinoma (SCC) possesses one of the worst prognoses out of the digestive carcinomas. Several studies have suggested that transforming growth factor β receptor type II (TGF-βRII), Smad family member 4 (Smad4) and p21 wild‑type p53‑activated factor 1 (p21waf1) are associated with esophageal SCC. The aim of the present study was to evaluate the effect of Smad4, TGF‑βRII and p21waf1 in esophageal squamous cancer tissue and the pathological significance of the effect. An immunohistochemical method was used to evaluate the expression levels of Smad4, TGF‑βRII and p21waf1 in specimens of esophageal SCC lesions obtained from 80 patients. It was found that the expression of Smad4, TGF‑βRII and p21waf1 in histologically‑classified grade I esophageal SCC, without invasion or lymph node metastasis, was markedly higher compared with grade III esophageal SCC that had invaded into the deep muscular or serous layer and metastasized to the lymph nodes (P<0.05). Analysis of the expression level of Smad4, TGF‑βRII and p21waf1, as well as the clinical and pathological characteristics of esophageal SCC, revealed that the three proteins may be associated with the carcinogenesis, biological behavior and prognosis of esophageal SCC, parallel to the pathological stage and cell grade.
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Copy and paste a formatted citation
Spandidos Publications style
Cheng H, Chen C, Liu L, Zhan N and Li B: Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue. Oncol Lett 9: 2847-2853, 2015.
APA
Cheng, H., Chen, C., Liu, L., Zhan, N., & Li, B. (2015). Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue. Oncology Letters, 9, 2847-2853. https://doi.org/10.3892/ol.2015.3146
MLA
Cheng, H., Chen, C., Liu, L., Zhan, N., Li, B."Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue". Oncology Letters 9.6 (2015): 2847-2853.
Chicago
Cheng, H., Chen, C., Liu, L., Zhan, N., Li, B."Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue". Oncology Letters 9, no. 6 (2015): 2847-2853. https://doi.org/10.3892/ol.2015.3146
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng H, Chen C, Liu L, Zhan N and Li B: Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue. Oncol Lett 9: 2847-2853, 2015.
APA
Cheng, H., Chen, C., Liu, L., Zhan, N., & Li, B. (2015). Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue. Oncology Letters, 9, 2847-2853. https://doi.org/10.3892/ol.2015.3146
MLA
Cheng, H., Chen, C., Liu, L., Zhan, N., Li, B."Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue". Oncology Letters 9.6 (2015): 2847-2853.
Chicago
Cheng, H., Chen, C., Liu, L., Zhan, N., Li, B."Expression of Smad4, TGF-βRII, and p21waf1 in esophageal squamous cell carcinoma tissue". Oncology Letters 9, no. 6 (2015): 2847-2853. https://doi.org/10.3892/ol.2015.3146
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