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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2015 Volume 10 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Anti‑metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA‑MB‑231 cells

  • Authors:
    • Chao Sun
    • Hongxia Cui
    • Hongyan Yang
    • Xiaohui Du
    • Liling Yue
    • Jicheng Liu
    • Yu Lin

  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China, The Institute of Medicine, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China
  • Pages: 1117-1122
    |
    Published online on: June 2, 2015
       https://doi.org/10.3892/ol.2015.3310
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Abstract

Tumor metastasis is the main cause of mortality in cancer patients. However, no effective therapies are currently available to prevent metastasis. Cell adhesion to the extracellular matrix (ECM) is crucial in cancer progression and metastasis. Thus, suppression of cell adhesion may be an effective therapeutic strategy for the prevention of metastasis. In the present study, the anti‑adhesion and anti‑invasion effects of jolkinolide B, a diterpenoid compound from Euphorbia fischeriana Steud, that were exerted through suppression of β1‑integrin expression and phosphorylation of focal adhesion kinase (FAK) were examined in human breast cancer MDA‑MB‑231 cells. Jolkinolide B inhibited the adhesion of MDA‑MB‑231 cells to fibronectin but not to poly‑L‑lysine. In addition, jolkinolide B inhibited extracellular signal‑regulated kinase (ERK) phosphorylation. U0126, an ERK inhibitor, also suppressed the invasion and adhesion of MDA‑MB‑231 cells. Overall, the present data demonstrated that jolkinolide B is a novel inhibitor of FAK‑mediated signaling pathways that is involved in decreasing cell adhesion and invasion. Mitogen‑activated protein kinase/ERK kinase may play a critical role in these effects, indicating that jolkinolide B possesses therapeutic potential for the treatment of breast cancer metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Sun C, Cui H, Yang H, Du X, Yue L, Liu J and Lin Y: Anti‑metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA‑MB‑231 cells. Oncol Lett 10: 1117-1122, 2015.
APA
Sun, C., Cui, H., Yang, H., Du, X., Yue, L., Liu, J., & Lin, Y. (2015). Anti‑metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA‑MB‑231 cells. Oncology Letters, 10, 1117-1122. https://doi.org/10.3892/ol.2015.3310
MLA
Sun, C., Cui, H., Yang, H., Du, X., Yue, L., Liu, J., Lin, Y."Anti‑metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA‑MB‑231 cells". Oncology Letters 10.2 (2015): 1117-1122.
Chicago
Sun, C., Cui, H., Yang, H., Du, X., Yue, L., Liu, J., Lin, Y."Anti‑metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA‑MB‑231 cells". Oncology Letters 10, no. 2 (2015): 1117-1122. https://doi.org/10.3892/ol.2015.3310
Copy and paste a formatted citation
x
Spandidos Publications style
Sun C, Cui H, Yang H, Du X, Yue L, Liu J and Lin Y: Anti‑metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA‑MB‑231 cells. Oncol Lett 10: 1117-1122, 2015.
APA
Sun, C., Cui, H., Yang, H., Du, X., Yue, L., Liu, J., & Lin, Y. (2015). Anti‑metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA‑MB‑231 cells. Oncology Letters, 10, 1117-1122. https://doi.org/10.3892/ol.2015.3310
MLA
Sun, C., Cui, H., Yang, H., Du, X., Yue, L., Liu, J., Lin, Y."Anti‑metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA‑MB‑231 cells". Oncology Letters 10.2 (2015): 1117-1122.
Chicago
Sun, C., Cui, H., Yang, H., Du, X., Yue, L., Liu, J., Lin, Y."Anti‑metastatic effect of jolkinolide B and the mechanism of activity in breast cancer MDA‑MB‑231 cells". Oncology Letters 10, no. 2 (2015): 1117-1122. https://doi.org/10.3892/ol.2015.3310
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