Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Common molecularcytogenetic alterations in tumors originating from the pineal region

  • Authors:
    • Florian Böhrnsen
    • Christina Enders
    • Hans-Christoph Ludwig
    • Wolfgang Brück
    • Laszlo Füzesi
    • Angelika Gutenberg
  • View Affiliations / Copyright

    Affiliations: Clinic of Oral and Maxillofacial Surgery, Georg-August University Göttingen, Göttingen D‑37075, Germany, Institute of Pathology, Georg-August University Göttingen, Göttingen D‑37075, Germany, Department of Neurosurgery, Georg-August University Göttingen, Göttingen D‑37075, Germany, Institute of Neuropathology, Georg-August University Göttingen, Göttingen D‑37075, Germany
  • Pages: 1853-1857
    |
    Published online on: June 17, 2015
       https://doi.org/10.3892/ol.2015.3383
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Tumors of the pineal region (PR) are rare and can be subdivided into four main histomorphological groups: Pineal-parenchymal tumors (PPT), germ cell tumors (GCT), glial tumors and miscellaneous tumors. The appropriate pathological classification and grading of these malignancies is essential for determining the clinical management and prognosis. However, an early diagnosis is often delayed due to unspecific clinical symptoms, and histological support is not always decisive to identify the diversity of tumors of the PR. The present study aimed to characterize 18 tumors of the PR using comparative genomic hybridization. All the tumors were primarily surgically resected without any previous irradiation or chemotherapy. In addition to chromosomal aberrations in PPT and different GCTs of the PR, the present study described, for the first time, the chromosomal changes in a few rare entities (solitary‑fibrous and neuroendocrine tumors) of the PR. The tumors in the study, regardless of histology and World Health Organization grade, were characterized by frequent gains at 7, 9q, 12q, 16p, 17 and 22q, and losses at 13q. While the detection of chromosomal aberrations in these tumors appears not to be indicative enough of histological entities and their grade of malignancy, the present data may be of use to select genes of interest for higher resolution genomic analyses.
View Figures

Figure 1

View References

1 

Rickert CH, Simon R, Bergmann M, Dockhorn-Dworniczak B and Paulus W: Comparative genomic hybridization in pineal parenchymal tumors. Genes Chromosomes Cancer. 30:99–104. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Edwards MS, Hudgins RJ, Wilson CB, Levin VA and Wara WM: Pineal region tumors in children. J Neurosurg. 68:689–697. 1988. View Article : Google Scholar : PubMed/NCBI

3 

Regis J, Bouillot P, Rouby-Volot F, Figarella-Branger D, Dufour H and Peragut JC: Pineal region tumors and the role of stereotactic biopsy: Review of the mortality, morbidity and diagnostic rates in 370 cases. Neurosurgery. 39:907–912. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Borja MJ, Plaza MJ, Altman N and Saigal G: Conventional and advanced MRI features of pediatric intracranial tumors: Supratentorial tumors. AJR Am J Roentgenol. 200:W483–W503. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW and Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 114:97–109. 2007. View Article : Google Scholar : PubMed/NCBI

6 

DeGirolami U and Schmidek H: Clinicopathological study of 53 tumors of the pineal region. J Neurosurg. 39:455–462. 1973. View Article : Google Scholar : PubMed/NCBI

7 

Kang JK, Jeun SS, Hong YK, Park CK, Son BC, Lee IW and Kim MC: Experience with pineal region tumors. Childs Nerv Syst. 14:63–68. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Al-Holou WN, Garton HJ, Muraszko KM, Ibrahim M and Maher CO: Prevalence of pineal cysts in children and young adults. Clinical article. J Neurosurg Pediatr. 4:230–236. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Smith AB, Rushing EJ and Smirniotopoulos JG: From the archives of the AFIP: Lesions of the pineal region: Radiologic-pathologic correlation. Radiographics. 30:2001–2020. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Pettorini BL, Al-Mahfoud R, Jenkinson MD, Avula S, Pizer B and Mallucci C: Surgical pathway and management of pineal region tumours in children. Childs Nerv Syst. 2012.

11 

Sajko T, Kudelic N, Lupret V, Lupret V Jr and Nola IA: Treatment of pineal region lesions: Our experience in 39 patients. Coll Antropol. 33:1259–1263. 2009.PubMed/NCBI

12 

Zhang J, Cheng H, Qiao Q, Zhang JS, Wang YM, Fu X and Li Q: Malignant solitary fibrous tumor arising from the pineal region: Case study and literature review. Neuropathology. 30:294–298. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Ozgural O, Kahilogullari G, Bozkurt M, Heper AO and Savas A: Primary pineal glioblastoma: A case report. Turk Neurosurg. 23:572–574. 2013.PubMed/NCBI

14 

Carson BS, Weingart JD, Guarnieri M and Fisher PG: Third ventricular choroid plexus papilloma with psychosis. Case report. J Neurosurg. 87:103–105. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Grozinsky-Glasberg S, Fichman S and Shimon I: Metastatic bronchial neuroendocrine tumor to the pineal gland: A unique manifestation of a rare disease. Hormones (Athens). 9:87–91. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Korogi Y, Takahashi M and Ushio Y: MRI of pineal region tumors. J Neurooncol. 54:251–261. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Dumrongpisutikul N, Intrapiromkul J and Yousem DM: Distinguishing between germinomas and pineal cell tumors on MR imaging. AJNR Am J Neuroradiol. 33:550–555. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Tosi MR, Ricci R, Bottura G and Tugnoli V: In vivo and in vitro nuclear magnetic resonance spectroscopy investigation of an intracranial mass. Oncol Rep. 8:1337–1339. 2001.PubMed/NCBI

19 

Legault G and Allen JC: Potential role of ventricular tumor markers in CNS germ cell tumors. Pediatr Blood Cancer. 60:1647–1650. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Seregni E, Massimino M, Nerini Molteni S, Pallotti F, van der Hiel B, Cefalo G, Spreafico F, Fossati F and Bombardieri E: Serum and cerebrospinal fluid human chorionic gonadotropin (hCG) and alpha-fetoprotein (AFP) in intracranial germ cell tumors. Int J Biol Markers. 17:112–118. 2002.PubMed/NCBI

21 

Leston J, Mottolese C, Champier J, Jouvet A, Brun J, Sindou M, Chazot G, Claustrat B and Fèvre-Montange M: Contribution of the daily melatonin profile to diagnosis of tumors of the pineal region. J Neurooncol. 93:387–394. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Korf HW, Gotz W, Herken R, Theuring F, Gruss P and Schachenmayr W: S-antigen and rod-opsin immunoreactions in midline brain neoplasms of transgenic mice: Similarities to pineal cell tumors and certain medulloblastomas in man. J Neuropathol Exp Neurol. 49:424–437. 1990. View Article : Google Scholar : PubMed/NCBI

23 

Behari S, Jaiswal S, Nair P, Garg P and Jaiswal AK: Tumors of the posterior third ventricular region in pediatric patients: The Indian perspective and a review of literature. J Pediatr Neurosci. 6:S56–71. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Gutenberg A, Brandis A, Hong B, Gunawan B, Enders C, Schaefer IM, Burger R, Ostertag H, Gaab M, Krauss JK, et al: Common molecular cytogenetic pathway in papillary tumors of the pineal region (PTPR). Brain Pathol. 21:672–677. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Berger AH, Knudson AG and Pandolfi PP: A continuum model for tumour suppression. Nature. 476:163–169. 2011. View Article : Google Scholar : PubMed/NCBI

26 

von Bueren AO, Gerss J, Hagel C, Cai H, Remke M, Hasselblatt M, Feuerstein BG, Pernet S, Delattre O, Korshunov A, et al: DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: An international individual patient data meta-analysis. J Neurooncol. 109:415–423. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Miller S, Rogers HA, Lyon P, Rand V, Adamowicz-Brice M, Clifford SC, Hayden JT, Dyer S, Pfister S, Korshunov A, et al: Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma. Neuro Oncol. 13:866–879. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Schneider DT, Zahn S, Sievers S, Alemazkour K, Reifenberger G, Wiestler OD, Calaminus G, Göbel U and Perlman EJ: Molecular genetic analysis of central nervous system germ cell tumors with comparative genomic hybridization. Mod Pathol. 19:864–873. 2006.PubMed/NCBI

29 

Rickert CH, Simon R, Bergmann M, Dockhorn-Dworniczak B and Paulus W: Comparative genomic hybridization in pineal germ cell tumors. J Neuropathol Exp Neurol. 59:815–821. 2000.PubMed/NCBI

30 

Sheikine Y, Genega E, Melamed J, Lee P, Reuter VE and Ye H: Molecular genetics of testicular germ cell tumors. Am J Cancer Res. 2:153–167. 2012.PubMed/NCBI

31 

Belirgen M, Berrak SG, Ozdag H, Bozkurt SU, Eksioglu-Demiralp E and Ozek MM: Biologic tumor behavior in pilocytic astrocytomas. Childs Nerv Syst. 28:375–389. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Sanoudou D, Tingby O, Ferguson-Smith MA, Collins VP and Coleman N: Analysis of pilocytic astrocytoma by comparative genomic hybridization. Br J Cancer. 82:1218–1222. 2000.PubMed/NCBI

33 

Lambert SR, Witt H, Hovestadt V, Zucknick M, Kool M, Pearson DM, Korshunov A, Ryzhova M, Ichimura K, Jabado N, et al: Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma. Acta Neuropathol. 126:291–301. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Hashemi J, Fotouhi O, Sulaiman L, Kjellman M, Höög A, Zedenius J and Larsson C: Copy number alterations in small intestinal neuroendocrine tumors determined by array comparative genomic hybridization. BMC Cancer. 13:5052013. View Article : Google Scholar : PubMed/NCBI

35 

Wang Y, Makedon F and Pearlman J: Tumor classification based on DNA copy number aberrations determined using SNP arrays. Oncol Rep. 15:1057–1059. 2006.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Böhrnsen F, Enders C, Ludwig H, Brück W, Füzesi L and Gutenberg A: Common molecularcytogenetic alterations in tumors originating from the pineal region. Oncol Lett 10: 1853-1857, 2015.
APA
Böhrnsen, F., Enders, C., Ludwig, H., Brück, W., Füzesi, L., & Gutenberg, A. (2015). Common molecularcytogenetic alterations in tumors originating from the pineal region. Oncology Letters, 10, 1853-1857. https://doi.org/10.3892/ol.2015.3383
MLA
Böhrnsen, F., Enders, C., Ludwig, H., Brück, W., Füzesi, L., Gutenberg, A."Common molecularcytogenetic alterations in tumors originating from the pineal region". Oncology Letters 10.3 (2015): 1853-1857.
Chicago
Böhrnsen, F., Enders, C., Ludwig, H., Brück, W., Füzesi, L., Gutenberg, A."Common molecularcytogenetic alterations in tumors originating from the pineal region". Oncology Letters 10, no. 3 (2015): 1853-1857. https://doi.org/10.3892/ol.2015.3383
Copy and paste a formatted citation
x
Spandidos Publications style
Böhrnsen F, Enders C, Ludwig H, Brück W, Füzesi L and Gutenberg A: Common molecularcytogenetic alterations in tumors originating from the pineal region. Oncol Lett 10: 1853-1857, 2015.
APA
Böhrnsen, F., Enders, C., Ludwig, H., Brück, W., Füzesi, L., & Gutenberg, A. (2015). Common molecularcytogenetic alterations in tumors originating from the pineal region. Oncology Letters, 10, 1853-1857. https://doi.org/10.3892/ol.2015.3383
MLA
Böhrnsen, F., Enders, C., Ludwig, H., Brück, W., Füzesi, L., Gutenberg, A."Common molecularcytogenetic alterations in tumors originating from the pineal region". Oncology Letters 10.3 (2015): 1853-1857.
Chicago
Böhrnsen, F., Enders, C., Ludwig, H., Brück, W., Füzesi, L., Gutenberg, A."Common molecularcytogenetic alterations in tumors originating from the pineal region". Oncology Letters 10, no. 3 (2015): 1853-1857. https://doi.org/10.3892/ol.2015.3383
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team