RAS/BRAF mutational status in familial non-medullary thyroid carcinomas: A retrospective study

  • Authors:
    • Matteo Landriscina
    • Maria Iole Natalicchio
    • Olga Lamacchia
    • Antonella Conserva
    • Annamaria Piscazzi
    • Anna Ciampolillo
    • Matteo Zingrillo
    • Antonio Pennella
    • Pantaleo Bufo
    • Giulia Vita
    • Raffaele Antonetti
    • Eugenio Maiorano
    • Francesco Giorgino
    • Mauro Cignarelli
  • View Affiliations

  • Published online on: June 17, 2015     https://doi.org/10.3892/ol.2015.3386
  • Pages: 1875-1881
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Abstract

There are contrasting views on whether familial non-medullary thyroid carcinomas (FNMTCs) are characterized by aggressive behavior, and limited evidence exists on the prognostic value of BRAF and RAS mutations in these tumors. Thus, in the present study, clinicopathological features were analyzed in 386 non‑medullary thyroid carcinomas (NMTCs), subdivided in 82 familial and 304 sporadic cases. Furthermore, the RAS and BRAF mutational statuses were investigated in a subgroup of 34 FNMTCs to address their clinical and biological significance. The results demonstrated that, compared with sporadic NMTCs, FNMTCs are characterized by significantly higher rates of multicentricity and bilaterality and are more frequently associated with chronic autoimmune thyroiditis. Notably, a statistically significant difference in the rates of multicentricity was observed by subgrouping familial tumors according to the number of relatives involved; those with ≥3 affected relatives were more likely to be multicentric. Furthermore, the FNMTC cohort exhibited higher rates of tumors >4 cm in size with extrathyroidal or lymph node involvement. However, no significant difference was observed. Similarly, no differences were observed with respect to the age of onset or the patient outcome. The mutational profiling exhibited a rate of 58.8% for BRAF V600E mutations in familial tumors, which is at the upper limit of the mutational frequency observed in historical series of sporadic thyroid cancer. A high rate of NRAS mutations (17.6%) was also observed, mostly in the follicular variant histotype. Notably, compared with BRAF/RAS‑wild type FNMTCs, the familial carcinomas bearing BRAF or NRAS mutations exhibited slightly higher rates of bilaterality and multicentricity, in addition to increased frequency of locally advanced stage or lymph node involvement. The present data support the theory that FNMTCs are characterized by clinicopathological features that resemble a more aggressive phenotype and suggest that RAS/BRAF mutational analysis deserves to be further evaluated as a tool for the identification of FNMTCs with a potentially unfavorable prognosis.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Landriscina M, Natalicchio MI, Lamacchia O, Conserva A, Piscazzi A, Ciampolillo A, Zingrillo M, Pennella A, Bufo P, Vita G, Vita G, et al: RAS/BRAF mutational status in familial non-medullary thyroid carcinomas: A retrospective study. Oncol Lett 10: 1875-1881, 2015
APA
Landriscina, M., Natalicchio, M.I., Lamacchia, O., Conserva, A., Piscazzi, A., Ciampolillo, A. ... Cignarelli, M. (2015). RAS/BRAF mutational status in familial non-medullary thyroid carcinomas: A retrospective study. Oncology Letters, 10, 1875-1881. https://doi.org/10.3892/ol.2015.3386
MLA
Landriscina, M., Natalicchio, M. I., Lamacchia, O., Conserva, A., Piscazzi, A., Ciampolillo, A., Zingrillo, M., Pennella, A., Bufo, P., Vita, G., Antonetti, R., Maiorano, E., Giorgino, F., Cignarelli, M."RAS/BRAF mutational status in familial non-medullary thyroid carcinomas: A retrospective study". Oncology Letters 10.3 (2015): 1875-1881.
Chicago
Landriscina, M., Natalicchio, M. I., Lamacchia, O., Conserva, A., Piscazzi, A., Ciampolillo, A., Zingrillo, M., Pennella, A., Bufo, P., Vita, G., Antonetti, R., Maiorano, E., Giorgino, F., Cignarelli, M."RAS/BRAF mutational status in familial non-medullary thyroid carcinomas: A retrospective study". Oncology Letters 10, no. 3 (2015): 1875-1881. https://doi.org/10.3892/ol.2015.3386