Nasopharyngeal chordoma in a patient with a severe form of sleep-disordered breathing: A case report

  • Authors:
    • Joanna Radzikowska
    • Zuzanna Gronkiewicz
    • Andrzej Kukwa
    • Wojciech Lisik
    • Anna M. Czarnecka
    • Antoni Krzeski
    • Wojciech Kukwa
  • View Affiliations

  • Published online on: June 19, 2015     https://doi.org/10.3892/ol.2015.3393
  • Pages: 1805-1809
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Abstract

Nasopharyngeal chordoma is a rare type of malignant neoplasm that originates in the remnants of the notochord, a primitive tissue of embryonic origin preserved outside the axial skeleton. Approximately one‑third of chordomas are located in the base of the skull, in the midline of the body. The slow growth rate of the tumor, which gradually fills the nasopharyngeal cavity, contributes to a delayed oncological diagnosis. Among its isolated and non‑specific symptoms, the obstruction of the nasopharynx is dominant, thus, sleep‑disordered breathing (SDB) may occur. The current study presents the case of a 32‑year‑old female patient who was incidentally diagnosed with a nasopharyngeal chordoma during a diagnostic examination for SDB. The diagnostic examination was performed as a part of a research program for pathologically obese patients who qualified for bariatric surgery. Following tumor resection, a significant improvement in various polysomnographic parameters occurred, including a decrease in the apnea hypopnea index from 53.5 to 6.4 and an increase in the mean saturation rate from 92.5 to 95%, confirming that an association exists between tumor obstruction of the nasopharynx and SDB. The incidental diagnosis of this rare type of neoplasm drew attention to diagnostic and therapeutic problems associated with nasopharyngeal chordomas. Furthermore, it indicated the necessity for the accurate laryngological examination of patients with SDB.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Radzikowska J, Gronkiewicz Z, Kukwa A, Lisik W, Czarnecka AM, Krzeski A and Kukwa W: Nasopharyngeal chordoma in a patient with a severe form of sleep-disordered breathing: A case report. Oncol Lett 10: 1805-1809, 2015
APA
Radzikowska, J., Gronkiewicz, Z., Kukwa, A., Lisik, W., Czarnecka, A.M., Krzeski, A., & Kukwa, W. (2015). Nasopharyngeal chordoma in a patient with a severe form of sleep-disordered breathing: A case report. Oncology Letters, 10, 1805-1809. https://doi.org/10.3892/ol.2015.3393
MLA
Radzikowska, J., Gronkiewicz, Z., Kukwa, A., Lisik, W., Czarnecka, A. M., Krzeski, A., Kukwa, W."Nasopharyngeal chordoma in a patient with a severe form of sleep-disordered breathing: A case report". Oncology Letters 10.3 (2015): 1805-1809.
Chicago
Radzikowska, J., Gronkiewicz, Z., Kukwa, A., Lisik, W., Czarnecka, A. M., Krzeski, A., Kukwa, W."Nasopharyngeal chordoma in a patient with a severe form of sleep-disordered breathing: A case report". Oncology Letters 10, no. 3 (2015): 1805-1809. https://doi.org/10.3892/ol.2015.3393