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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-2015 Volume 10 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report

  • Authors:
    • Yuehong Wang
    • Yi Hong Shen
    • Shanni Ma
    • Jianying Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Disease, The First Affiliated Hospital of the College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 1575-1578
    |
    Published online on: June 22, 2015
       https://doi.org/10.3892/ol.2015.3405
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Abstract

The present study reports the case of an 84-year-old male with primary pulmonary large cell neuroendocrine carcinoma (LCNEC) harboring an epidermal growth factor receptor (EGFR) gene mutation that exhibited a long‑lasting response to the EGFR‑tyrosine kinase inhibitor (EGFR‑TKI) icotinib. The patient had an extensive smoking history, a poor performance status, and presented with an irregular mass in the middle lobe of the right lung on computed tomography (CT) and an enlarged left supraclavicular lymph node on physical examination. Right middle lobe bronchial brushing during fiberoptic bronchoscopy identified poorly‑differentiated cancer cells. The left supraclavicular lymph node was biopsied and a diagnosis of metastatic LCNEC was determined. Furthermore, an EGFR exon 19 deletion was identified by DNA sequencing. Following diagnosis, icotinib was administered at a dose of 125 mg three times a day. Chest CT scans were performed after 1 month of treatment, which indicated that the tumor was in partial remission. This marked response to icotinib lasted for 8 months. Thus, the present case illustrates the possibility of identifying EGFR mutations in LCNEC and indicates that EGFR‑tyrosine kinase inhibitors may be an alternative treatment strategy for patients with LCNEC harboring activating EGFR mutations.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Shen YH, Ma S and Zhou J: A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report. Oncol Lett 10: 1575-1578, 2015.
APA
Wang, Y., Shen, Y.H., Ma, S., & Zhou, J. (2015). A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report. Oncology Letters, 10, 1575-1578. https://doi.org/10.3892/ol.2015.3405
MLA
Wang, Y., Shen, Y. H., Ma, S., Zhou, J."A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report". Oncology Letters 10.3 (2015): 1575-1578.
Chicago
Wang, Y., Shen, Y. H., Ma, S., Zhou, J."A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report". Oncology Letters 10, no. 3 (2015): 1575-1578. https://doi.org/10.3892/ol.2015.3405
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Shen YH, Ma S and Zhou J: A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report. Oncol Lett 10: 1575-1578, 2015.
APA
Wang, Y., Shen, Y.H., Ma, S., & Zhou, J. (2015). A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report. Oncology Letters, 10, 1575-1578. https://doi.org/10.3892/ol.2015.3405
MLA
Wang, Y., Shen, Y. H., Ma, S., Zhou, J."A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report". Oncology Letters 10.3 (2015): 1575-1578.
Chicago
Wang, Y., Shen, Y. H., Ma, S., Zhou, J."A marked response to icotinib in a patient with large cell neuroendocrine carcinoma harboring an EGFR mutation: A case report". Oncology Letters 10, no. 3 (2015): 1575-1578. https://doi.org/10.3892/ol.2015.3405
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