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Article

C-X-C motif receptor 7 in gastrointestinal cancer (Review)

  • Authors:
    • Hwan‑Jung Yun
    • Hyewon Ryu
    • Yoon Seok Choi
    • Ik‑Chan Song
    • Deog‑Yeon Jo
    • Samyong Kim
    • Hyo Jin Lee
  • View Affiliations / Copyright

    Affiliations: Division of Hematology/Oncology, Department of Internal Medicine, Chungnam National University Hospital, Daejeon 301‑721, Republic of Korea
  • Pages: 1227-1232
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    Published online on: June 22, 2015
       https://doi.org/10.3892/ol.2015.3407
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Abstract

Chemokine receptors are key mediators of normal physiology and numerous pathological conditions, including inflammation and cancer. This receptor family is an emerging target for anticancer drug development. C‑X‑C motif receptor 7 (CXCR7) is an atypical chemokine receptor that was first cloned from a canine cDNA library as an orphan receptor and was initially named receptor dog cDNA 1 (RDC1). Shortly after demonstrating that RDC1 binds with its ligand, stromal cell‑derived factor‑1α and interferon‑inducible T‑cell α chemoattractant, RDC1 was officially deorphanized and renamed CXCR7, as the seventh receptor in the CXC class of the chemokine receptor family. Recent accumulating evidence has demonstrated that CXCR7 expression is augmented in the majority of tumor cells compared with their normal counterparts and is involved in cell proliferation, survival, migration, invasion and angiogenesis during the initiation and progression of breast, lung and prostate cancer. In the present review, the expression and role of CXCR7, as well as its clinical relevance in cancer of the gastrointestinal system, were investigated. In addition, the potential of this chemokine receptor as a therapeutic target in the treatment of gastrointestinal cancer was discussed.
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1 

Bachelerie F, Ben-Baruch A, Burkhardt AM, Combadiere C, Farber JM, Graham GJ, Horuk R, Sparre-Ulrich AH, Locati M, Luster AD, et al: International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacol Rev. 66:1–79. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Lee HJ, Song IC, Yun HJ, Jo DY and Kim S: CXC chemokines and chemokine receptors in gastric cancer: From basic findings towards therapeutic targeting. World J Gastroenterol. 20:1681–1693. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Balkwill FR: The chemokine system and cancer. J Pathol. 226:148–157. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Lee HJ and Jo DY: The role of the CXCR4/CXCL12 axis and its clinical implications in gastric cancer. Histol Histopathol. 27:1155–1161. 2012.PubMed/NCBI

5 

Libert F, Parmentier M, Lefort A, Dumont JE and Vassart G: Complete nucleotide sequence of a putative G protein coupled receptor: RDC1. Nucleic Acids Res. 18:19171990. View Article : Google Scholar : PubMed/NCBI

6 

Sánchez-Martín L, Sánchez-Mateos P and Cabañas C: CXCR7 impact on CXCL12 biology and disease. Trends Mol Med. 19:12–22. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Tarnowski M, Liu R, Wysoczynski M, Ratajczak J, Kucia M and Ratajczak MZ: CXCR7: A new SDF-1-binding receptor in contrast to normal CD34(+) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells. Eur J Haematol. 85:472–483. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, et al: Interferon-inducible T cell alpha chemoattractant (I-TAC): A novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med. 187:2009–2021. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Maksym RB, Tarnowski M, Grymula K, Tarnowska J, Wysoczynski M, Liu R, Czerny B, Ratajczak J, Kucia M and Ratajczak MZ: The role of stromal-derived factor-1 - CXCR7 axis in development and cancer. Eur J Pharmacol. 625:31–40. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Hartmann TN, Grabovsky V, Pasvolsky R, Shulman Z, Buss EC, Spiegel A, Nagler A, Lapidot T, Thelen M and Alon R: A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J Leukoc Biol. 84:1130–1140. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Infantino S, Moepps B and Thelen M: Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. J Immunol. 176:2197–2207. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Mazzinghi B, Ronconi E, Lazzeri E, Sagrinati C, Ballerini L, Angelotti ML, Parente E, Mancina R, Netti GS, Becherucci F, et al: Essential but differential role for CXCR4 and CXCR7 in the therapeutic homing of human renal progenitor cells. J Exp Med. 205:479–490. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Naumann U, Cameroni E, Pruenster M, Mahabaleshwar H, Raz E, Zerwes HG, Rot A and Thelen M: CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS One. 5:e91752010. View Article : Google Scholar : PubMed/NCBI

14 

Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, et al: A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J Exp Med. 203:2201–2213. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Eva C and Sprengel R: A novel putative G protein-coupled receptor highly expressed in lung and testis. DNA Cell Biol. 12:393–399. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, Simons MJ, Dumont JE and Vassart G: Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science. 244:569–572. 1989. View Article : Google Scholar : PubMed/NCBI

17 

Tripathi V, Verma R, Dinda A, Malhotra N, Kaur J and Luthra K: Differential expression of RDC1/CXCR7 in the human placenta. J Clin Immunol. 29:379–386. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Sun X, Cheng G, Hao M, Zheng J, Zhou X, Zhang J, Taichman RS, Pienta KJ and Wang J: CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev. 29:709–722. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Keeley EC, Mehrad B and Strieter RM: CXC chemokines in cancer angiogenesis and metastases. Adv Cancer Res. 106:91–111. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Raggo C, Ruhl R, McAllister S, Koon H, Dezube BJ, Früh K and Moses AV: Novel cellular genes essential for transformation of endothelial cells by Kaposi's sarcoma-associated herpesvirus. Cancer Res. 65:5084–5095. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Miao Z, Luker KE, Summers BC, Berahovich R, Bhojani MS, Rehemtulla A, Kleer CG, Essner JJ, Nasevicius A, Luker GD, et al: CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc Natl Acad Sci USA. 104:15735–15740. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Loberg R and Taichman RS: The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem. 283:4283–4294. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Berahovich RD, Zabel BA, Penfold ME, Lewén S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, et al: CXCR7 protein is not expressed on human or mouse leukocytes. J Immunol. 185:5130–5139. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Bennani-Baiti IM, Cooper A, Lawlor ER, Kauer M, Ban J, Aryee DN and Kovar H: Intercohort gene expression co-analysis reveals chemokine receptors as prognostic indicators in Ewing's sarcoma. Clin Cancer Res. 16:3769–3778. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Tarnowski M, Grymula K, Reca R, Jankowski K, Maksym R, Tarnowska J, Przybylski G, Barr FG, Kucia M and Ratajczak MZ: Regulation of expression of stromal-derived factor-1 receptors: CXCR4 and CXCR7 in human rhabdomyosarcomas. Mol Cancer Res. 8:1–14. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Van Rechem C, Rood BR, Touka M, Pinte S, Jenal M, Guérardel C, Ramsey K, Monté D, Bégue A, Tschan MP, et al: Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1). J Biol Chem. 284:20927–20935. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Calatozzolo C, Canazza A, Pollo B, Di Pierro E, Ciusani E, Maderna E, Salce E, Sponza V, Frigerio S, Di Meco F, et al: Expression of the new CXCL12 receptor, CXCR7, in gliomas. Cancer Biol Ther. 11:242–253. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Hattermann K, Held-Feindt J, Lucius R, Müerköster SS, Penfold ME, Schall TJ and Mentlein R: The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects. Cancer Res. 70:3299–3308. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Mehra R, Serebriiskii IG, Burtness B, Astsaturov I and Golemis EA: Aurora kinases in head and neck cancer. Lancet Oncol. 14:e425–e435. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Miyazaki H, Takabe K and Yeudall WA: Chemokines, chemokine receptors and the gastrointestinal system. World J Gastroenterol. 19:2847–2863. 2013.PubMed/NCBI

31 

Yeudall WA and Miyazaki H: Chemokines and squamous cancer of the head and neck: Targets for therapeutic intervention? Expert Rev Anticancer Ther. 7:351–360. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Xia J, Wang J, Chen N, Dai Y, Hong Y, Chen X and Cheng B: Expressions of CXCR7/ligands may be involved in oral carcinogenesis. J Mol Histol. 42:175–180. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Maussang D, Mujić-Delić A, Descamps FJ, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, Vischer HF, van Roy M, Vosjan M, Gonzalez-Pajuelo M, et al: Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo. J Biol Chem. 288:29562–29572. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Ge XS, Ma HJ, Zheng XH, Ruan HL, Liao XY, Xue WQ, Chen YB, Zhang Y and Jia WH: HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway. Cancer Sci. 104:1675–1682. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Tachezy M, Zander H, Gebauer F, von Loga K, Pantel K, Izbicki JR and Bockhorn M: CXCR7 expression in esophageal cancer. J Transl Med. 11:2382013. View Article : Google Scholar : PubMed/NCBI

36 

Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, Wada H, Date H and Miyahara R: Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer. Cancer. 115:2580–2593. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Zhi Y, Chen J, Zhang S, Chang X, Ma J and Dai D: Down-regulation of CXCL12 by DNA hypermethylation and its involvement in gastric cancer metastatic progression. Dig Dis Sci. 57:650–659. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Xu H, Wu Q, Dang S, Jin M, Xu J, Cheng Y, Pan M, Wu Y, Zhang C and Zhang Y: Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma. PLoS One. 6:e273992011. View Article : Google Scholar : PubMed/NCBI

39 

Guillemot E, Karimdjee-Soilihi B, Pradelli E, Benchetrit M, Goguet-Surmenian E, Millet MA, Larbret F, Michiels JF, Birnbaum D, Alemanno P, et al: CXCR7 receptors facilitate the progression of colon carcinoma within lung not within liver. Br J Cancer. 107:1944–1949. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Romain B, Hachet-Haas M, Rohr S, Brigand C, Galzi JL, Gaub MP, Pencreach E and Guenot D: Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer. Mol Cancer. 13:582014. View Article : Google Scholar : PubMed/NCBI

41 

Rupertus K, Sinistra J, Scheuer C, Nickels RM, Schilling MK, Menger MD and Kollmar O: Interaction of the chemokines I-TAC (CXCL11) and SDF-1 (CXCL12) in the regulation of tumor angiogenesis of colorectal cancer. Clin Exp Metastasis. 31:447–459. 2014. View Article : Google Scholar

42 

Heckmann D, Maier P, Laufs S, Li L, Sleeman JP, Trunk MJ, Leupold JH, Wenz F, Zeller WJ, Fruehauf S, et al: The disparate twins: A comparative study of CXCR4 and CXCR7 in SDF-1α -induced gene expression, invasion and chemosensitivity of colon cancer. Clin Cancer Res. 20:604–616. 2014. View Article : Google Scholar : PubMed/NCBI

43 

D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, et al: A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients. Int J Cancer. 135:379–390. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Kheirelseid EA, Miller N, Chang KH, Nugent M and Kerin MJ: Clinical applications of gene expression in colorectal cancer. J Gastrointest Oncol. 4:144–157. 2013.PubMed/NCBI

45 

Wang L, Zhang X, Jia LT, Hu SJ, Zhao J, Yang JD, Wen WH, Wang Z, Wang T, Zhao J, et al: c-Myc-mediated epigenetic silencing of MicroRNA-101 contributes to dysregulation of multiple pathways in hepatocellular carcinoma. Hepatology. 59:1850–1863. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Xue TC, Chen RX, Han D, Chen J, Xue Q, Gao DM, Sun RX, Tang ZY and Ye SL: Down-regulation of CXCR7 inhibits the growth and lung metastasis of human hepatocellular carcinoma cells with highly metastatic potential. Exp Ther Med. 3:117–123. 2012.PubMed/NCBI

47 

Xue TC, Han D, Chen RX, Zou JH, Wang Y, Tang ZY and Ye SL: High expression of CXCR7 combined with Alpha fetoprotein in hepatocellular carcinoma correlates with extra-hepatic metastasis to lung after hepatectomy. Asian Pac J Cancer Prev. 12:657–663. 2011.PubMed/NCBI

48 

Zheng K, Li HY, Su XL, Wang XY, Tian T, Li F and Ren GS: Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells. J Exp Clin Cancer Res. 29:312010. View Article : Google Scholar : PubMed/NCBI

49 

Monnier J, Boissan M, L'Helgoualc'h A, Lacombe ML, Turlin B, Zucman-Rossi J, Théret N, Piquet-Pellorce C and Samson M: CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells. Eur J Cancer. 48:138–148. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Ghanem I, Riveiro ME, Paradis V, Faivre S, de Parga PM and Raymond E: Insights on the CXCL12-CXCR4 axis in hepatocellular carcinoma carcinogenesis. Am J Transl Res. 6:340–352. 2014.PubMed/NCBI

51 

Xue TC, Jia QA, Bu Y, Chen RX, Cui JF, Tang ZY and Ye SL: CXCR7 correlates with the differentiation of hepatocellular carcinoma and suppresses HNF4α expression through the ERK pathway. Oncol Rep. 32:2387–2396. 2014.PubMed/NCBI

52 

Xue TC, Chen RX, Ren ZG, Zou JH, Tang ZY and Ye SL: Transmembrane receptor CXCR7 increases the risk of extrahepatic metastasis of relatively well-differentiated hepatocellular carcinoma through upregulation of osteopontin. Oncol Rep. 30:105–110. 2013.PubMed/NCBI

53 

Hong TS, Ryan DP, Borger DR, Blaszkowsky LS, Yeap BY, Ancukiewicz M, Deshpande V, Shinagare S, Wo JY, Boucher Y, et al: A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma. Int J Radiat Oncol Biol Phys. 89:830–838. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Heinrich EL, Lee W, Lu J, Lowy AM and Kim J: Chemokine CXCL12 activates dual CXCR4 and CXCR7-mediated signaling pathways in pancreatic cancer cells. J Transl Med. 10:682012. View Article : Google Scholar : PubMed/NCBI

55 

Guo JC, Li J, Yang YC, Zhou L, Zhang TP and Zhao YP: Oligonucleotide microarray identifies genes differentially expressed during tumorigenesis of DMBA-induced pancreatic cancer in rats. PLoS One. 8:e829102013. View Article : Google Scholar : PubMed/NCBI

56 

Gebauer F, Tachezy M, Effenberger K, von Loga K, Zander H, Marx A, Kaifi JT, Sauter G, Izbicki JR and Bockhorn M: Prognostic impact of CXCR4 and CXCR7 expression in pancreatic adenocarcinoma. J Surg Oncol. 104:140–145. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Weekes CD, Song D, Arcaroli J, Wilson LA, Rubio-Viqueira B, Cusatis G, Garrett-Mayer E, Messersmith WA, Winn RA and Hidalgo M: Stromal cell-derived factor 1α mediates resistance to mTOR-directed therapy in pancreatic cancer. Neoplasia. 14:690–701. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB and Dwinell MB: CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. PLoS One. 9:e904002014. View Article : Google Scholar : PubMed/NCBI

59 

Maréchal R, Demetter P, Nagy N, Berton A, Decaestecker C, Polus M, Closset J, Devière J, Salmon I and Van Laethem JL: High expression of CXCR4 may predict poor survival in resected pancreatic adenocarcinoma. Br J Cancer. 100:1444–1451. 2009. View Article : Google Scholar : PubMed/NCBI

60 

Yao X, Zhou L, Han S and Chen Y: High expression of CXCR4 and CXCR7 predicts poor survival in gallbladder cancer. J Int Med Res. 39:1253–1264. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Zabel BA, Wang Y, Lewén S, Berahovich RD, Penfold ME, Zhang P, Powers J, Summers BC, Miao Z, Zhao B, et al: Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 183:3204–3211. 2009. View Article : Google Scholar : PubMed/NCBI

62 

Luker KE, Gupta M and Luker GD: Imaging chemokine receptor dimerization with firefly luciferase complementation. FASEB J. 23:823–834. 2009. View Article : Google Scholar : PubMed/NCBI

63 

Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D and Jain RK: CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: An emerging sensitizer for anticancer therapies? Clin Cancer Res. 17:2074–2080. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Dai X, Xiong X, Wang L, Pan K, He L and Li H: Effects of CXCR7-shRNA lentiviral vector on the growth and invasiveness of human hepatoma carcinoma cells in vitro. Nan Fang Yi Ke Da Xue Xue Bao. 33:994–998. 2013.(In Chinese). PubMed/NCBI

65 

Ribas R, Ghazoui Z, Gao Q, Pancholi S, Rani A, Dunbier A, Dowsett M and Martin LA: Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor-positive breast cancers. Breast Cancer Res. 16:4472014. View Article : Google Scholar : PubMed/NCBI

66 

Walters MJ, Ebsworth K, Berahovich RD, Penfold ME, Liu SC, Al Omran R, Kioi M, Chernikova SB, Tseng D, Mulkearns-Hubert EE, et al: Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats. Br J Cancer. 110:1179–1188. 2014. View Article : Google Scholar : PubMed/NCBI

67 

Hou KL, Hao MG, Bo JJ and Wang JH: CXCR7 in tumorigenesis and progression. Chin J Cancer. 29:456–459. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yun HJ, Ryu H, Choi YS, Song IC, Jo DY, Kim S and Lee HJ: C-X-C motif receptor 7 in gastrointestinal cancer (Review) . Oncol Lett 10: 1227-1232, 2015.
APA
Yun, H., Ryu, H., Choi, Y.S., Song, I., Jo, D., Kim, S., & Lee, H.J. (2015). C-X-C motif receptor 7 in gastrointestinal cancer (Review) . Oncology Letters, 10, 1227-1232. https://doi.org/10.3892/ol.2015.3407
MLA
Yun, H., Ryu, H., Choi, Y. S., Song, I., Jo, D., Kim, S., Lee, H. J."C-X-C motif receptor 7 in gastrointestinal cancer (Review) ". Oncology Letters 10.3 (2015): 1227-1232.
Chicago
Yun, H., Ryu, H., Choi, Y. S., Song, I., Jo, D., Kim, S., Lee, H. J."C-X-C motif receptor 7 in gastrointestinal cancer (Review) ". Oncology Letters 10, no. 3 (2015): 1227-1232. https://doi.org/10.3892/ol.2015.3407
Copy and paste a formatted citation
x
Spandidos Publications style
Yun HJ, Ryu H, Choi YS, Song IC, Jo DY, Kim S and Lee HJ: C-X-C motif receptor 7 in gastrointestinal cancer (Review) . Oncol Lett 10: 1227-1232, 2015.
APA
Yun, H., Ryu, H., Choi, Y.S., Song, I., Jo, D., Kim, S., & Lee, H.J. (2015). C-X-C motif receptor 7 in gastrointestinal cancer (Review) . Oncology Letters, 10, 1227-1232. https://doi.org/10.3892/ol.2015.3407
MLA
Yun, H., Ryu, H., Choi, Y. S., Song, I., Jo, D., Kim, S., Lee, H. J."C-X-C motif receptor 7 in gastrointestinal cancer (Review) ". Oncology Letters 10.3 (2015): 1227-1232.
Chicago
Yun, H., Ryu, H., Choi, Y. S., Song, I., Jo, D., Kim, S., Lee, H. J."C-X-C motif receptor 7 in gastrointestinal cancer (Review) ". Oncology Letters 10, no. 3 (2015): 1227-1232. https://doi.org/10.3892/ol.2015.3407
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