Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study

  • Authors:
    • Shangtong Lei
    • Zihai Ding
    • Junna Ge
    • Donghui Zhao
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Anatomical Institute of Minimally Invasive Surgery, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 1749-1754
    |
    Published online on: June 24, 2015
       https://doi.org/10.3892/ol.2015.3416
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Differentiated thyroid carcinoma (DTC) is one of the most common metabolic disorders and accounts for 98% of all cases of thyroid cancer. Previously, a number of studies have investigated the prognostic factors associated with well‑differentiated thyroid carcinoma (WDTC); however, these studies yielded conflicting results. The current study used a retrospective study design to collect data from WDTC patients who had received the same treatment regimen from the same institute, with a minimum follow‑up of 10 years. The De Groot staging system was used to classify WDTC in a total of 320 patients (240 females and 80 males). Among the subjects, the pathological subtypes identified were as follows: Papillary carcinoma (240 cases, 75%), follicular carcinoma (67 cases, 21%) and Hürthle cell carcinoma (13 cases, 4%). Prognostic factors that significantly affected the clinical outcome of the disease were advanced age (P=0.001), tumor size (P=0.03), presence of thyroglobulin (P=0.001) and De Groot stage (P=0.005). The 10‑year follow‑up study revealed that WDTC is associated with a high survival rate of 96% (307/320 patients survived) and a low mortality rate (4%).
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Kebebew E and Clark OH: Differentiated thyroid cancer: “complete” rational approach. World J Surg. 24:942–951. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Ringel MD and Ladenson PW: Controversies in the follow-up and management of well-differentiated thyroid cancer. Endocr Relat Cancer. 11:97–116. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Caron NR and Clark OH: Well differentiated thyroid cancer. Scand J Surg. 93:261–271. 2004.PubMed/NCBI

4 

Patel KN and Shaha AR: Poorly differentiated and anaplastic thyroid cancer. Cancer Control. 13:119–128. 2006.PubMed/NCBI

5 

Cushing SL, Palm CE, Audet N, Eski S, Walfish PG and Freeman JL: Prognostic factors in well-differentiated thyroid carcinoma. Laryngoscope. 114:2110–2115. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Mazzaferri EL: An overview of the management of papillary and follicular thyroid carcinoma. Thyroid. 9:421–427. 1999. View Article : Google Scholar : PubMed/NCBI

7 

Akslen LA and LiVolsi VA: Prognostic significance of histologic grading compared with subclassification of papillary thyroid carcinoma. Cancer. 88:1902–1908. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Sugg SL, Zheng L, Rosen IB, Freeman JL, Ezzat S and Asa SL: ret/PTC-1, -2 and -3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential? J Clin Endocrinol Metab. 81:3360–3365. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Tuttle RM: Differentiated thyroid cancer: Clinicopathologic staging. http://www.uptodate.com/contents/differentiated-thyroid-cancer-clinicopathologic-stagingOctober 6th–2013

10 

DeGroot LJ, Kaplan EL, McCormick M and Straus FH: Natural history, treatment, and course of papillary thyroid carcinoma. J Clin Endocrinol Metab. 71:414–424. 1990. View Article : Google Scholar : PubMed/NCBI

11 

Kebebew E and Clark OH: Differentiated thyroid cancer: “Complete” rational approach. World J Surg. 24:942–951. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Rami-Porta R, Crowley JJ and Goldstraw P: The revised TNM staging system for lung cancer. Ann Thorac Cardiovasc Surg. 15:4–9. 2009.PubMed/NCBI

13 

Weetman AP: Expert Consult: ThyroiditisConn's Current Therapy 2012. Bope ET and Kellerman RD: Elsevier Saunders; Philadelphia, USA: 2012

14 

Elisei R, Molinaro E, Agate L, et al: Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question. J Clin Endocrinol Metab. 95:1516–1527. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Tanaka K, Sonoo H, Saito W, Ohta Y, Shimo T, Sohda M, Yamamoto Y and Kurebayashi J: Analysis of clinical outcome of patients with poorly differentiated thyroid carcinoma. ISRN Endocrinol. 2011:3080292011. View Article : Google Scholar : PubMed/NCBI

16 

Holler T, Theriault J, Payne RJ, Clark J, Eski S and Freeman JL: Prognostic factors in patients with multiple recurrences of well-differentiated thyroid carcinoma. J Oncol. 2009:6503402009. View Article : Google Scholar : PubMed/NCBI

17 

Palme CE, Waseem Z, Raza SN, Eski S, Walfish P and Freeman JL: Management and outcome of recurrent well-differentiated thyroid carcinoma. Arch Otolaryngol Head Neck Surg. 130:819–824. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Fonseca E, Soares P, Rossi S and Sobrinho-Simões M: Prognostic factors in differentiated thyroid gland carcinoma. Pathologe. 18:275–285. 1997. View Article : Google Scholar : PubMed/NCBI

19 

Akslen LA, Myking AO, Salvesen H and Varhaug JE: Prognostic importance of various clinicopathological features in papillary thyroid carcinoma. Eur J Cancer. 29A:44–51. 1992.PubMed/NCBI

20 

Mazzaferri EL and Jhiang SM: Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med. 97:418–428. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Baloch ZW and LiVolsi VA: Prognostic factors in well-differentiated follicular-derived carcinoma and medullary thyroid carcinoma. Thyroid. 11:637–645. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Schlumberger M and Pacini F: Thyroid tumors. 2nd. Nucléon Editions; Paris, France: pp. 18–24. 2003

23 

Lin JD, Chao TC and Hsueh C: Clinical characteristics of poorly differentiated thyroid carcinomas compared with those of classical papillary thyroid carcinomas. Clin Endocrinol (Oxf). 66:224–228. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Nishida T, Katayama M, Tsujimoto M, Nakamura J and Matsuda H: Clinicopathological significance of poorly differentiated thyroid carcinoma. Am J Surg Pathol. 23:205–211. 1999. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lei S, Ding Z, Ge J and Zhao D: Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study. Oncol Lett 10: 1749-1754, 2015.
APA
Lei, S., Ding, Z., Ge, J., & Zhao, D. (2015). Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study. Oncology Letters, 10, 1749-1754. https://doi.org/10.3892/ol.2015.3416
MLA
Lei, S., Ding, Z., Ge, J., Zhao, D."Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study". Oncology Letters 10.3 (2015): 1749-1754.
Chicago
Lei, S., Ding, Z., Ge, J., Zhao, D."Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study". Oncology Letters 10, no. 3 (2015): 1749-1754. https://doi.org/10.3892/ol.2015.3416
Copy and paste a formatted citation
x
Spandidos Publications style
Lei S, Ding Z, Ge J and Zhao D: Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study. Oncol Lett 10: 1749-1754, 2015.
APA
Lei, S., Ding, Z., Ge, J., & Zhao, D. (2015). Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study. Oncology Letters, 10, 1749-1754. https://doi.org/10.3892/ol.2015.3416
MLA
Lei, S., Ding, Z., Ge, J., Zhao, D."Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study". Oncology Letters 10.3 (2015): 1749-1754.
Chicago
Lei, S., Ding, Z., Ge, J., Zhao, D."Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study". Oncology Letters 10, no. 3 (2015): 1749-1754. https://doi.org/10.3892/ol.2015.3416
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team