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Case Report

Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature

  • Authors:
    • Li Gong
    • Wen‑Dong Zhang
    • Xiao‑Rong Mu
    • Xiu‑Juan Han
    • Li Yao
    • Shao‑Jun Zhu
    • Fu‑Qin Zhang
    • Yan‑Hong Li
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: The Helmholtz Sino‑German Laboratory for Cancer Research, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China, Department of Gynaecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China
  • Pages: 1565-1568
    |
    Published online on: June 25, 2015
       https://doi.org/10.3892/ol.2015.3422
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Abstract

Metastases to the gingival soft tissues are rare in hepatocellular carcinoma (HCC). To the best of our knowledge, only 13 cases have been reported in English literature to date. The present study described the case of a 43‑year‑old Chinese man who was admitted to Tangdu Hospital (Xi'an, China) due to the presence of a gingival tumor that was initially diagnosed as granulation tissue by a dental surgeon. Examination of the patient's medical history revealed that a solid mass, measuring 1.5 cm in diameter, was identified in the right lobe of the liver 2 years prior to presentation at the current hospital; however, no biopsy was performed. Thus, the tumor was resected and histological examination resulted in an initial diagnosis of atypical squamous cell carcinoma. However, the histopathological characteristics, immunohistochemical features and serum α‑fetoprotein expression levels supported a diagnosis of metastatic HCC. In conclusion, the present case study highlights the difficulties in diagnosing metastatic HCC without a history of primary HCC, and the importance of excluding a diagnosis of metastatic tumor when a lesion is identified in the gingival. Furthermore, it was determined that a final diagnosis of gingival metastasis of HCC predominantly depends on pathological characteristics and immunohistochemical features.
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1 

International Agency for Research on Cancer, . Liver cancer: Estimated incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspxDecember 12–2013

2 

Sawabe M, Nakamura T, Kanno J and Kasuga T: Analysis of morphological factors of hepatocellular carcinoma in 98 autopsy cases with respect to pulmonary metastasis. Acta Pathol Jpn. 37:1389–1404. 1987.PubMed/NCBI

3 

Katyal S, Oliver JH III, Peterson MS, Ferris JV, Carr BS and Baron RL: Extrahepatic metastases of hepatocellular carcinoma. Radiology. 216:698–703. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Natsuizaka M, Omura T, Akaike T, et al: Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol. 20:1781–1787. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Watanabe J, Nakashima O and Kojiro M: Clinicopathologic study on lymph node metastasis of hepatocellular carcinoma: A retrospective study of 660 consecutive autopsy cases. Jpn J Clin Oncol. 24:37–41. 1994.PubMed/NCBI

6 

Lapeyrolerie FM and Manhold JH Jr: Hepatoma metastasic to the gingiva. Oral Surg Oral Med Oral Pathol. 18:365–367. 1964. View Article : Google Scholar : PubMed/NCBI

7 

Lund BA, Soule EH and Moertel CG: Hepatocellular carcinoma with metastasis to gingival mucosa: Report of case. J Oral Surg. 28:604–607. 1970.PubMed/NCBI

8 

Llanes F, Sanz-Ortega J, Suarez B and Sanz-Esponera J: Hepatocellular carcinomas diagnosed following metastasis to the oral cavity. Report of 2 cases. J Periodontol. 67:717–719. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Radden BF and Reade PC: Gingival metastasis from a hepatoma. Oral Surg Oral Med Oral Pathol. 21:621–625. 1966. View Article : Google Scholar : PubMed/NCBI

10 

Wedgwood D, Rusen D and Balk S: Gingival metastasis from primary hepatocellular carcinoma. Report of a case. Oral Surg Oral Med Oral Pathol. 47:263–266. 1979. View Article : Google Scholar : PubMed/NCBI

11 

Nishimura Y, Yakata H, Kawasaki T and Nakajima T: Metastatic tumours of the mouth and jaws. A review of the Japanese literature. J Oral Maxillofac Surg. 10:253–258. 1982.

12 

Morishita M and Fukuda J: Hepatocellular carcinoma metastatic to the maxillary incisal gingiva. J Oral Maxillofac Surg. 42:812–815. 1984. View Article : Google Scholar : PubMed/NCBI

13 

Maiorano E, Piattelli A and Favia G: Hepatocellular carcinoma metastatic to the oral mucosa: Report of a case with multiple gingival localizations. J Periodontol. 71:641–645. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Kanazawa H and Sato K: Gingival metastasis from primary hepatocellular carcinoma: Report of a case and review of literature. J Oral Maxillofac Surg. 47:987–990. 1989. View Article : Google Scholar : PubMed/NCBI

15 

Ramón Ramirez J, Seoane J, Montero J, Esparza Gómez GC and Cerero R: Isolated gingival metastasis from hepatocellular carcinoma mimicking a pyogenic granuloma. J Clin Periodontol. 30:926–929. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Greenstein A, Witherspoon R, Iqbal F and Coleman H: Hepatocellular carcinoma metastasis to the maxilla: A rare case. Aust Dent J. 58:373–375. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Terada T: Hepatocellular carcinoma metastatic to the gingiva as a first manifestation of hepatocellular carcinoma. J Maxillofac Oral Surg. 10:271–274. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Rosai J: Surgical Pathology. Ninth. Mosby; Maryland Heights, MO: pp. 998–1001. 2004

19 

Hamilton SR and Aaltonen LA: Pathology & Genetics of Tumours of the Digestive SystemWorld Health Organization Classification of Tumours. 2nd. IARC Press; Lyon, France: pp. 161–166. 2000

20 

Hujoel PP, Drangsholt M, Spiekerman C and Weiss NS: An exploration of the periodontitis-cancer association. Ann Epidemiol. 13:312–316. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Tezal M, Sullivan MA, Hyland A, Marshall JR, Stoler D, Reid ME, Loree TR, Rigual NR, Merzianu M, Hauck L, et al: Chronic periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 18:2406–2412. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Tezal M, Sullivan MA, Reid ME, Marshall JR, Hyland A, Loree T, Lillis C, Hauck L, Wactawski-Wende J and Scannapieco FA: Chronic periodontitis and the risk of tongue cancer. Arch Otolaryngol Head Neck Surg. 133:450–454. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Tamaki N, Takaki A, Tomofuji T, Endo Y, Kasuyama K, Ekuni D, Yasunaka T, Yamamoto K and Morita M: Stage of hepatocellular carcinoma is associated with periodontitis. J Clin Periodontol. 38:1015–1020. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Sculley DV and Langley-Evans SC: Salivary antioxidants and periodontal disease status. Proc Nutr Soc. 61:137–143. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Severi T, van Malenstein H, Verslype C and van Pelt JF: Tumor initiation and progression in hepatocellular carcinoma: Risk factors, classification, and therapeutic targets. Acta Pharmacol Sin. 31:1409–1420. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Hirshberg A, Leibovich P and Buchner A: Metastases to the oral mucosa: Analysis of 157 cases. J Oral Pathol Med. 22:385–390. 1993. View Article : Google Scholar : PubMed/NCBI

27 

Will TA, Agarwal N and Petruzzelli GJ: Oral cavity metastasis of renal cell carcinoma: A case report. J Med Case Reports. 2:3132008. View Article : Google Scholar

28 

Makos CP and Psomaderis K: A literature review in renal carcinoma metastasis to the oral mucosa and a new report of an epulis-like metastasis. J Oral Maxillofac Surg. 67:653–660. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Edmondson HA and Steiner PE: Primary carcinoma of the liver: A study of 100 cases among 48,900 necropsies. Cancer. 7:462–503. 1954. View Article : Google Scholar : PubMed/NCBI

30 

Hu H, Duan Z, Long X, Hertzanu Y, Shi H, Liu S and Yang Z: Sorafenib combined with transarterial chemoembolization versus transarterial chemoembolization alone for advanced-stage hepatocellular carcinoma: A propensity score matching study. PLoS One. 9:e966202014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gong L, Zhang WD, Mu XR, Han XJ, Yao L, Zhu SJ, Zhang FQ, Li YH and Zhang W: Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature. Oncol Lett 10: 1565-1568, 2015.
APA
Gong, L., Zhang, W., Mu, X., Han, X., Yao, L., Zhu, S. ... Zhang, W. (2015). Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature. Oncology Letters, 10, 1565-1568. https://doi.org/10.3892/ol.2015.3422
MLA
Gong, L., Zhang, W., Mu, X., Han, X., Yao, L., Zhu, S., Zhang, F., Li, Y., Zhang, W."Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature". Oncology Letters 10.3 (2015): 1565-1568.
Chicago
Gong, L., Zhang, W., Mu, X., Han, X., Yao, L., Zhu, S., Zhang, F., Li, Y., Zhang, W."Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature". Oncology Letters 10, no. 3 (2015): 1565-1568. https://doi.org/10.3892/ol.2015.3422
Copy and paste a formatted citation
x
Spandidos Publications style
Gong L, Zhang WD, Mu XR, Han XJ, Yao L, Zhu SJ, Zhang FQ, Li YH and Zhang W: Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature. Oncol Lett 10: 1565-1568, 2015.
APA
Gong, L., Zhang, W., Mu, X., Han, X., Yao, L., Zhu, S. ... Zhang, W. (2015). Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature. Oncology Letters, 10, 1565-1568. https://doi.org/10.3892/ol.2015.3422
MLA
Gong, L., Zhang, W., Mu, X., Han, X., Yao, L., Zhu, S., Zhang, F., Li, Y., Zhang, W."Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature". Oncology Letters 10.3 (2015): 1565-1568.
Chicago
Gong, L., Zhang, W., Mu, X., Han, X., Yao, L., Zhu, S., Zhang, F., Li, Y., Zhang, W."Hepatocellular carcinoma metastasis to the gingival soft tissues: A case report and review of the literature". Oncology Letters 10, no. 3 (2015): 1565-1568. https://doi.org/10.3892/ol.2015.3422
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