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Article

Prognostic factors for elderly patients with primary malignant bone and soft tissue tumors

  • Authors:
    • Tadashi Iwai
    • Manabu Hoshi
    • Jun Takada
    • Naoto Oebisu
    • Masanari Aono
    • Masatsugu Takami
    • Makoto Ieguchi
    • Hiroaki Nakamura
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Abeno‑Ku, Osaka 545‑8585, Japan
  • Pages: 1799-1804
    |
    Published online on: June 29, 2015
       https://doi.org/10.3892/ol.2015.3432
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Abstract

The number of patients with primary malignant bone and soft tissue tumors in Japan is increasing in line with the increasing size of the elderly population. The aim of the present study was to determine the prognostic factors of primary malignant bone or soft tissue tumors in elderly patients. Clinical data was obtained from 90 patients, aged ≥65 years, with primary malignant bone or soft tissue tumors (bone, 20 cases; and soft tissue, 70 cases), treated at the Osaka City University Hospital between 1993 and 2013. Clinical information prior to treatment and tumor type, location, size, depth, grade and American Society of Anesthesiologists‑Physical Status (ASA‑PS) score were evaluated in order to identify prognostic factors using the Cox proportional hazards regression model. In addition, 5‑year survival rates were evaluated using the Kaplan‑Meier method. The average follow‑up period was 44.8 months and the 5‑year overall survival rate was 77.5%. In the multivariate analysis, ASA‑PS score and high‑grade sarcoma were found to be associated with a poorer overall survival. No significant differences were observed between the patient group aged 65‑74 years and that aged ≥75 years. In general, aging is associated with physically reduced function and an increased prevalence of comorbidities. It was therefore expected that increasing age may be a predictive factor for poor prognosis. However, the results of the present study suggested that ASA‑PS score and tumor grade were significant factors associated with poor prognosis, whereas increasing age was not. Therefore, the treatment of elderly patients with primary bone and soft tissue tumors should not be based on age.
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Copy and paste a formatted citation
Spandidos Publications style
Iwai T, Hoshi M, Takada J, Oebisu N, Aono M, Takami M, Ieguchi M and Nakamura H: Prognostic factors for elderly patients with primary malignant bone and soft tissue tumors. Oncol Lett 10: 1799-1804, 2015.
APA
Iwai, T., Hoshi, M., Takada, J., Oebisu, N., Aono, M., Takami, M. ... Nakamura, H. (2015). Prognostic factors for elderly patients with primary malignant bone and soft tissue tumors. Oncology Letters, 10, 1799-1804. https://doi.org/10.3892/ol.2015.3432
MLA
Iwai, T., Hoshi, M., Takada, J., Oebisu, N., Aono, M., Takami, M., Ieguchi, M., Nakamura, H."Prognostic factors for elderly patients with primary malignant bone and soft tissue tumors". Oncology Letters 10.3 (2015): 1799-1804.
Chicago
Iwai, T., Hoshi, M., Takada, J., Oebisu, N., Aono, M., Takami, M., Ieguchi, M., Nakamura, H."Prognostic factors for elderly patients with primary malignant bone and soft tissue tumors". Oncology Letters 10, no. 3 (2015): 1799-1804. https://doi.org/10.3892/ol.2015.3432
Copy and paste a formatted citation
x
Spandidos Publications style
Iwai T, Hoshi M, Takada J, Oebisu N, Aono M, Takami M, Ieguchi M and Nakamura H: Prognostic factors for elderly patients with primary malignant bone and soft tissue tumors. Oncol Lett 10: 1799-1804, 2015.
APA
Iwai, T., Hoshi, M., Takada, J., Oebisu, N., Aono, M., Takami, M. ... Nakamura, H. (2015). Prognostic factors for elderly patients with primary malignant bone and soft tissue tumors. Oncology Letters, 10, 1799-1804. https://doi.org/10.3892/ol.2015.3432
MLA
Iwai, T., Hoshi, M., Takada, J., Oebisu, N., Aono, M., Takami, M., Ieguchi, M., Nakamura, H."Prognostic factors for elderly patients with primary malignant bone and soft tissue tumors". Oncology Letters 10.3 (2015): 1799-1804.
Chicago
Iwai, T., Hoshi, M., Takada, J., Oebisu, N., Aono, M., Takami, M., Ieguchi, M., Nakamura, H."Prognostic factors for elderly patients with primary malignant bone and soft tissue tumors". Oncology Letters 10, no. 3 (2015): 1799-1804. https://doi.org/10.3892/ol.2015.3432
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