Hodgkin's lymphoma associated with myelofibrosis: A case report

Fu,Rong; Yu,Hong; Wu,Yu‑Hong; Liu,Hui; Shao,Zong‑Hong

doi:10.3892/ol.2015.3438

Hodgkin's lymphoma associated with myelofibrosis: A case report

Authors:
- Rong Fu
- Hong Yu
- Yu‑Hong Wu
- Hui Liu
- Zong‑Hong Shao
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Affiliations: Department of Hematology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
Published online on: June 30, 2015 https://doi.org/10.3892/ol.2015.3438
Pages: 1551-1554

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Abstract

In the present study, the case of a patient with nodular sclerosing Hodgkin's lymphoma (NSHL) presenting with diffuse fibrosis of the bone marrow (BM) was reported. A 30‑year‑old male complained of fever for 1 year, as well as lumbago, lymph node swelling and night sweats for 3 months. A biopsy of the lymph nodes established a diagnosis of NSHL. Aspiration of BM was a dry tap, and the BM biopsy demonstrated marked myelofibrosis with increased proliferation of reticulin fiber. Multiple skeletal lesions were detected in the patient's vertebra, pelvis, sternum and bilateral femur by magnetic resonance imaging and computed tomography. Following numerous courses of chemotherapy and radiotherapy, remission of the lymphoma was achieved. Subsequently, the BM aspiration became possible, and BM biopsy demonstrated a reduction in fibrosis.

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