Open Access

Anticancer potential of selected Fallopia Adans species

  • Authors:
    • Octavian Tudorel Olaru
    • Luanne Venables
    • Maryna van de Venter
    • George Mihai Nitulescu
    • Denisa Margina
    • Demetrios A. Spandidos
    • Aristidis M. Tsatsakis
  • View Affiliations

  • Published online on: July 2, 2015     https://doi.org/10.3892/ol.2015.3453
  • Pages: 1323-1332
  • Copyright: © Olaru et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to determine the anticancer potential of three species belonging to the Fallopia genus (Polygonaceae): Fallopia convolvulus (F. convolvulus, Fallopia dumetorum  (F. dumetorum) and Fallopia aubertii (F. aubertii). For this purpose, crude extracts were obtained and characterized for their phenolic and flavonoid total content and examined for their anticancer activity on three tumor cell lines: breast cancer (MCF7), colon carcinoma (Caco-2) and cervical cancer (HeLa) cells. The cytotoxic potential of the three species was assessed by MTT assay, cell cycle analysis and by the evaluation of mitochondrial membrane potential (MMP). The acute toxicity of the extracts was evaluated using one in vitro cell model (Vero cells, an African Green monkey kidney cell line) and two invertebrate in vivo models (Daphnia magna and Artemia salina). The highest total phenolic and flavonoid content was found in the F. aubertii flower extracts. The cytotoxic effects of the extracts from F. aubertii and F. convolvulus on all three cell lines were examined at concentrations ranging from 3 to 300 µg/ml. G2/M cell cycle arrest was induced by all the extracts, and a significant increase in the subG1 cell population was observed. The hydroethanolic extract from the flowers of F. aubertii induced cell apoptosis more rapidly than the other extracts. The MMP indicates the involvement of the mitochondria in the induction of apoptosis. A positive correlation between the total phenolic content of the extracts and the IC50 values against the HeLa cells was also noted. None of the extracts exhibited significantly toxic effects. Considering the antitumor potential of F. aubertii and F. convolvulus, these two species may represent a good source of plant extracts with anticancer properties.
View Figures
View References

Related Articles

Journal Cover

September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Olaru OT, Venables L, van de Venter M, Nitulescu GM, Margina D, Spandidos DA and Tsatsakis AM: Anticancer potential of selected Fallopia Adans species. Oncol Lett 10: 1323-1332, 2015
APA
Olaru, O.T., Venables, L., van de Venter, M., Nitulescu, G.M., Margina, D., Spandidos, D.A., & Tsatsakis, A.M. (2015). Anticancer potential of selected Fallopia Adans species. Oncology Letters, 10, 1323-1332. https://doi.org/10.3892/ol.2015.3453
MLA
Olaru, O. T., Venables, L., van de Venter, M., Nitulescu, G. M., Margina, D., Spandidos, D. A., Tsatsakis, A. M."Anticancer potential of selected Fallopia Adans species". Oncology Letters 10.3 (2015): 1323-1332.
Chicago
Olaru, O. T., Venables, L., van de Venter, M., Nitulescu, G. M., Margina, D., Spandidos, D. A., Tsatsakis, A. M."Anticancer potential of selected Fallopia Adans species". Oncology Letters 10, no. 3 (2015): 1323-1332. https://doi.org/10.3892/ol.2015.3453