Insights into the roles of hnRNP A2/B1 and AXL in non‑small cell lung cancer

  • Authors:
    • Xiao‑Han Qu
    • Jin‑Lu Liu
    • Xin‑Wen Zhong
    • Xi Li
    • Qi‑Gang Zhang
  • View Affiliations

  • Published online on: July 3, 2015     https://doi.org/10.3892/ol.2015.3457
  • Pages: 1677-1685
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Abstract

Lung cancer has long been one of the most serious types of malignant tumor, and is associated with high incidence and mortality rates. Despite advancements in the comprehensive treatment of the disease, particularly with targeted therapeutic agents, there has been little improvement in the 5‑year survival rates of patients. One of the leading causes of mortality in lung cancer is the lack of effective early diagnostic criteria. On this basis, the present study aimed to identify an index with potential in the early diagnosis and prognosis of lung cancer. The current study determined the expression of heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 and AXL proteins in non‑small cell lung cancer (NSCLC) tumor samples, and performed prognostic analysis of the collected clinical data to identify any association. In addition, RNA interference was performed to silence the expression of hnRNP A2/B1, allowing evaluation of its molecular and cellular functions, and determination of the mechanism of hnRNP A2/B1 in NSCLC by means of AXL mediation. It was identified that the positive expression rate of hnRNP A2/B1 and AXL proteins were significantly higher in NSCLC compared with paracancerous lung tissues (P<0.05). Furthermore, the expression of hnRNP A2/B1 protein was correlated with the expression AXL. Thus, the expression of hnRNP A2/B1 and AXL protein are factors affecting prognosis in patients with NSCLC. Of these, hnRNP A2/B1 appears to be an independent risk factor.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Qu XH, Liu JL, Zhong XW, Li X and Zhang QG: Insights into the roles of hnRNP A2/B1 and AXL in non‑small cell lung cancer. Oncol Lett 10: 1677-1685, 2015
APA
Qu, X., Liu, J., Zhong, X., Li, X., & Zhang, Q. (2015). Insights into the roles of hnRNP A2/B1 and AXL in non‑small cell lung cancer. Oncology Letters, 10, 1677-1685. https://doi.org/10.3892/ol.2015.3457
MLA
Qu, X., Liu, J., Zhong, X., Li, X., Zhang, Q."Insights into the roles of hnRNP A2/B1 and AXL in non‑small cell lung cancer". Oncology Letters 10.3 (2015): 1677-1685.
Chicago
Qu, X., Liu, J., Zhong, X., Li, X., Zhang, Q."Insights into the roles of hnRNP A2/B1 and AXL in non‑small cell lung cancer". Oncology Letters 10, no. 3 (2015): 1677-1685. https://doi.org/10.3892/ol.2015.3457