Knockdown of Aurora-B inhibits the growth of non-small cell lung cancer A549 cells

  • Authors:
    • Jing Jing Yu
    • Long Dian Zhou
    • Tian Tian Zhao
    • Wei Bai
    • Jing Zhou
    • Wei Zhang
  • View Affiliations

  • Published online on: July 8, 2015     https://doi.org/10.3892/ol.2015.3467
  • Pages: 1642-1648
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Abstract

Elevated expression of Aurora-B affects cell apoptosis and proliferation in a variety of solid tumors. However, the role of Aurora-B has been poorly evaluated in non‑small cell lung cancer (NSCLC). In the present study, it was found that Aurora‑B was overexpressed in tissue specimens obtained from 174 patients with lung cancer. It was also demonstrated that knockdown of Aurora‑B induces apoptosis and inhibits the growth of lung cancer A549 cells in vitro and in vivo. Furthermore, it was found that silencing Aurora‑B decreased the activity of the phosphoinositide 3‑kinase (PI3K)/AKT pathway. Therefore, it was concluded that knockdown of Aurora‑B induces apoptosis and inhibits growth in NSCLC A549 cells, in addition to inhibiting the activity of the PI3K/AKT signaling pathway. Targeting Aurora-B may provide a novel target for lung cancer therapy.

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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yu JJ, Zhou LD, Zhao TT, Bai W, Zhou J and Zhang W: Knockdown of Aurora-B inhibits the growth of non-small cell lung cancer A549 cells. Oncol Lett 10: 1642-1648, 2015
APA
Yu, J.J., Zhou, L.D., Zhao, T.T., Bai, W., Zhou, J., & Zhang, W. (2015). Knockdown of Aurora-B inhibits the growth of non-small cell lung cancer A549 cells. Oncology Letters, 10, 1642-1648. https://doi.org/10.3892/ol.2015.3467
MLA
Yu, J. J., Zhou, L. D., Zhao, T. T., Bai, W., Zhou, J., Zhang, W."Knockdown of Aurora-B inhibits the growth of non-small cell lung cancer A549 cells". Oncology Letters 10.3 (2015): 1642-1648.
Chicago
Yu, J. J., Zhou, L. D., Zhao, T. T., Bai, W., Zhou, J., Zhang, W."Knockdown of Aurora-B inhibits the growth of non-small cell lung cancer A549 cells". Oncology Letters 10, no. 3 (2015): 1642-1648. https://doi.org/10.3892/ol.2015.3467