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Article

Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma

  • Authors:
    • Luxia Chen
    • Yanjin He
    • Shizhen Sun
    • Baocun Sun
    • Xin Tang
  • View Affiliations / Copyright

    Affiliations: Clinical College of Ophthalmology, Tianjin Medical University, Tianjin Eye Hospital and Eye Institute, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin 300020, P.R. China, Tianjin Medical University Eye Hospital, Tianjin Medical University Eye Research Institute, Tianjin 300384, P.R. China, Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300070, P.R. China
  • Pages: 1635-1641
    |
    Published online on: July 8, 2015
       https://doi.org/10.3892/ol.2015.3469
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Abstract

Vasculogenic mimicry (VM) is a key developmental program, frequently activated during cancer invasion and metastasis. The aim of the present study was to evaluate the role of VM in orbital rhabdomyosarcoma (RMS), the correlation between VM and tumor differentiation, recurrence and survival duration, as well as the contribution of epithelial cell kinase (EphA2) and matrix metalloproteinase‑2 (MMP‑2) in VM initiation. A total of 32 patients were enrolled to investigate the associations between VM in orbital RMS tumors and clinical characteristics, as well as its impact on overall survival. VM was identified and confirmed by CD31/periodic acid‑Schiff double staining, while the presence of EphA2 and MMP‑2 were examined by immunohistochemical analysis. VM was identified in eleven patients, particularly those with poorly differentiated orbital RMS (P=0.001). Patients with VM exhibited significantly worse survival rates (P=0.001, log‑rank test), a significantly increased risk of mortality (P=0.008) and EphA2 and MMP‑2 expression levels were enhanced (P=0.005 and 0.001, respectively). The VM and mitotic rate were independent predictors of poor prognosis (P=0.001 and 0.004, respectively), indicated by multivariate Cox proportional hazards models. These results demonstrated that VM is present in orbital RMS and represents an independent prognostic factor for overall survival. In addition, overexpression of EphA2 and MMP-2 may promote VM formation in orbital RMS.
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1 

Morax S and Desjardins L: Orbital tumor emergencies in childhood. J Fr Ophtalmol. 32:357–367. 2009.(In French). View Article : Google Scholar : PubMed/NCBI

2 

Boutroux H, Levy C, Mosseri V, Desjardins L, Plancher C, Helfre S, Freneaux P, Cellier C and Orbach D: Long-term evaluation of orbital rhabdomyosarcoma in children. Clin Experiment Ophthalmol. 43:12–19. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Maniotis AJ, Folberg R, Hess A, Seftor EA, Gardner LM, Pe'er J, Trent JM, Meltzer PS and Hendrix MJ: Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry. Am J Pathol. 155:739–752. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Sun B, Zhang S, Zhang D, Du J, Guo H, Zhao X, Zhang W and Hao X: Vasculogenic mimicry is associated with high tumor grade, invasion and metastasis and short survival in patients with hepatocellular carcinoma. Oncol Rep. 16:693–698. 2006.PubMed/NCBI

5 

Sun T, Zhao N, Zhao XL, Gu Q, Zhang SW, Che N, Wang XH, Du J, Liu YX and Sun BC: Expression and functional significance of Twist1 in hepatocellular carcinoma: Its role in vasculogenic mimicry. Hepatology. 51:545–556. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Hendrix MJ, Seftor EA, Hess AR and Seftor RE: Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma. Nat Rev Cancer. 3:411–421. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Hao X, Sun B, Zhang S and Zhao X: Microarray study of vasculogenic mimicry in bi-directional differentiation malignant tumor. Zhonghua Yi Xue Za Zhi. 82:1298–1302. 2002.(In Chinese). PubMed/NCBI

8 

Wang W, Lin P, Sun B, Zhang S, Cai W, Han C, Li L, Lu H and Zhao X: Epithelial-mesenchymal transition regulated by EphA2 contributes to vasculogenic mimicry formation of head and neck squamous cell carcinoma. Bio Med Res Int. 2014:8039142014.

9 

Kirschmann DA, Seftor EA, Hardy KM, Seftor RE and Hendrix MJ: Molecular pathways: Vasculogenic mimicry in tumor cells: Diagnostic and therapeutic implications. Clin Cancer Res. 18:2726–2732. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Chen LX, He YJ, Zhao SZ, Wu JG, Wang JT, Zhu LM, Lin TT, Sun BC and Li XR: Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model. Cancer Biol Ther. 11:229–235. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Sun B, Qie S, Zhang S, Sun T, Zhao X, Gao S, Ni C, Wang X, Liu Y and Zhang L: Role and mechanism of vasculogenic mimicry in gastrointestinal stromal tumors. Hum Pathol. 39:444–451. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Sun B, Zhang S, Zhao X, Zhang W and Hao X: Vasculogenic mimicry is associated with poor survival in patients with mesothelial sarcomas and alveolar rhabdomyosarcomas. Int J Oncol. 25:1609–1614. 2004.PubMed/NCBI

13 

Turner JH and Richmon JD: Head and neck rhabdomyosarcoma: A critical analysis of population-based incidence and survival data. Otolaryngol Head Neck Surg. 145:967–973. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Chung EM, Smirniotopoulos JG, Specht CS, Schroeder JW and Cube R: From the archives of the AFIP: Pediatric orbit tumors and tumorlike lesions: Nonosseous lesions of the extraocular orbit. Radiographics. 27:1777–1799. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Rustemeyer J, Günther L and Junker K: Limits and chances in an unfortunate course of recurrent orbital rhabdomyosarcoma. Nepal J Ophthalmol. 3:202–205. 2011.PubMed/NCBI

16 

Seftor RE, Hess AR, Seftor EA, Kirschmann DA, Hardy KM, Margaryan NV and Hendrix MJ: Tumor cell vasculogenic mimicry: From controversy to therapeutic promise. Am J Pathol. 181:1115–1125. 2012. View Article : Google Scholar : PubMed/NCBI

17 

van der Schaft DW, Hillen F, Pauwels P, Kirschmann DA, Castermans K, Egbrink MG, Tran MG, Sciot R, Hauben E, Hogendoorn PC, et al: Tumor cell plasticity in Ewing sarcoma, an alternative circulatory system stimulated by hypoxia. Cancer Res. 65:11520–11528. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Mourad-Zeidan AA, Melnikova VO, Wang H, Raz A and Bar-Eli M: Expression profiling of galectin-3-depleted melanoma cells reveals its major role in melanoma cell plasticity and vasculogenic mimicry. Am J Pathol. 173:1839–1852. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Desch A, Strozyk EA, Bauer AT, Huck V, Niemeyer V, Wieland T and Schneider SW: Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin αvβ5-induced secretion of VEGF-A. Am J Pathol. 181:693–705. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Chen X, Maniotis AJ, Majumdar D, Pe'er J and Folberg R: Uveal melanoma cell staining for CD34 and assessment of tumor vascularity. Invest Ophthalmol Vis Sci. 43:2533–2539. 2002.PubMed/NCBI

21 

Hendrix MJ, Seftor EA, Hess AR and Seftor RE: Molecular plasticity of human melanoma cells. Oncogene. 22:3070–3075. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Folberg R and Maniotis AJ: Vasculogenic mimicry. APMIS. 112:508–525. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Hess AR, Seftor EA, Gardner LM, Carles-Kinch K, Schneider GB, Seftor RE, Kinch MS and Hendrix MJ: Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: Role of epithelial cell kinase (Eck/EphA2). Cancer Res. 61:3250–3255. 2001.PubMed/NCBI

24 

Seftor RE, Seftor EA, Koshikawa N, Meltzer PS, Gardner LM, Bilban M, Stetler-Stevenson WG, Quaranta V and Hendrix MJ: Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2 and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma. Cancer Res. 61:6322–6327. 2001.PubMed/NCBI

25 

Hess AR, Seftor EA, Seftor RE and Hendrix MJ: Phosphoinositide 3-kinase regulates membrane type 1-matrix metalloproteinase (MMP) and MMP-2 activity during melanoma cell vasculogenic mimicry. Cancer Res. 63:4757–4762. 2003.PubMed/NCBI

26 

Chen LX, Sun BC, Li XR, He YJ and Song GX: Overexpression of the receptor tyrosine kinase EphA2 in choroidal melanoma: Correlation with vasculogenic mimicry and prognosis. Zhonghua Yan Ke Za Zhi. 48:985–990. 2012.(In Chinese). PubMed/NCBI

27 

Qie S, Sun BC, Zhao XL, Zhang SW, Sun T, Gao SY and Wang XH: Correlation between expressions of matrix metalloproteinase-2 & 9 and vasculogenic mimicry in gastrointestinal stromal tumors. Zhonghua Yi Xue Za Zhi. 89:1106–1109. 2009.(In Chinese). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen L, He Y, Sun S, Sun B and Tang X: Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma. Oncol Lett 10: 1635-1641, 2015.
APA
Chen, L., He, Y., Sun, S., Sun, B., & Tang, X. (2015). Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma. Oncology Letters, 10, 1635-1641. https://doi.org/10.3892/ol.2015.3469
MLA
Chen, L., He, Y., Sun, S., Sun, B., Tang, X."Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma". Oncology Letters 10.3 (2015): 1635-1641.
Chicago
Chen, L., He, Y., Sun, S., Sun, B., Tang, X."Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma". Oncology Letters 10, no. 3 (2015): 1635-1641. https://doi.org/10.3892/ol.2015.3469
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, He Y, Sun S, Sun B and Tang X: Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma. Oncol Lett 10: 1635-1641, 2015.
APA
Chen, L., He, Y., Sun, S., Sun, B., & Tang, X. (2015). Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma. Oncology Letters, 10, 1635-1641. https://doi.org/10.3892/ol.2015.3469
MLA
Chen, L., He, Y., Sun, S., Sun, B., Tang, X."Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma". Oncology Letters 10.3 (2015): 1635-1641.
Chicago
Chen, L., He, Y., Sun, S., Sun, B., Tang, X."Vasculogenic mimicry is a major feature and novel predictor of poor prognosis in patients with orbital rhabdomyosarcoma". Oncology Letters 10, no. 3 (2015): 1635-1641. https://doi.org/10.3892/ol.2015.3469
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