Lambert‑Eaton myasthenic syndrome in a patient with small‑cell lung cancer: A case report

Zhang,Ran‑Ran; Han,Tao; Guo,Fang; Liu,Zhao‑Zhe; Han,Ya‑Ling; Chen,Wei‑Chi; Liu,Yong‑Ye; Xie,Xiao‑Dong

doi:10.3892/ol.2015.3473

September-2015 Volume 10 Issue 3

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September-2015 Volume 10 Issue 3

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Case Report Open Access

Lambert‑Eaton myasthenic syndrome in a patient with small‑cell lung cancer: A case report

Authors:
- Ran‑Ran Zhang
- Tao Han
- Fang Guo
- Zhao‑Zhe Liu
- Ya‑Ling Han
- Wei‑Chi Chen
- Yong‑Ye Liu
- Xiao‑Dong Xie
View Affiliations / Copyright

Affiliations: Department of Oncology, Cancer Center, People's Liberation Army General Hospital of Shenyang Military Region, Shenyang, Liaoning 110016, P.R. China, Department of Cardiology, Institute of Cardiovascular Research, People's Liberation Army General Hospital of Shenyang Military Region, Shenyang, Liaoning 110016, P.R. China

Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 1339-1342
|
Published online on: July 8, 2015

https://doi.org/10.3892/ol.2015.3473
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Abstract

Lambert‑Eaton myasthenic syndrome (LEMS) is a neuromuscular junction disorder characterized by fluctuating proximal limb muscle weakness, decreased deep tendon reflexes and various autonomic symptoms. LEMS is reportedly the most common neurological paraneoplastic syndrome. This is the case report of a patient with small‑cell lung cancer (SCLC) who developed LEMS. A 68‑year‑old male patient presented with a 6‑month history of progressive weakness of the proximal limbs and a 2‑month history of xerostomia. The patient was admitted to the Department of Neurology of the People's Liberation Army General Hospital of Shenyang Military Region (Shenyang, China). the symptoms of the patient were not relieved with supportive therapy. Further laboratory tests, electrodiagnostic studies, chest computed tomography and immunohistochemical staining confirmed the diagnosis of LEMS in the presence of SCLC. Following administration of two cycles of rescue chemotherapy with a combination of etoposide and cisplatin, the symptoms of the patient were gradually relieved and, after six cycles of therapy, the primary malignancy completely regressed. In conclusion, a diagnosis of LEMS may lead to the timely detection of SCLC, significantly improving patient prognosis and survival.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Lambert‑Eaton myasthenic syndrome in a patient with small‑cell lung cancer: A case report

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