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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-2015 Volume 10 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

Expression and mutation analysis of Cyclin A and Ki‑67 in glioma and their correlation with tumor progression

  • Authors:
    • Cheng Miao
    • Zhiyong Wang
    • Jing Yang
    • Jing Li
    • Xunzhao Gao
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China, Department of Anatomy, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China, Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 1716-1720
    |
    Published online on: July 8, 2015
       https://doi.org/10.3892/ol.2015.3474
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Abstract

The present study aimed to analyze the expression and mutation of Cyclin A and Ki‑67 in gliomas, and determine their correlation with tumor progression. Tissue samples of 186 diagnosed glioma patients were examined immunohistochemically for Cyclin A and Ki‑67 expression. Gene mutation analysis was performed on genomic DNA extracted from patient samples, using polymerase chain reaction amplification and sequencing. Cyclin A and Ki‑67 expression were observed in the glioma and lymphatic metastasis tissues, and were analyzed using SPSS 14.0 statistical software. Of the total patients, 64 (34.41%) were Cyclin A‑positive and 68 (36.56%) were Ki‑67‑positive. The expression of Cyclin A and Ki‑67 in glioma was positively correlated with lymphatic metastasis. Statistically significant differences were observed in the mutation rate of Ki‑67 (P<0.05), but not Cyclin A (P>0.05), between the gliomas and metastatic tumors. In conclusion, Cyclin A and Ki‑67 are highly expressed in glioma tissues, and their expression and mutation are associated with the lymphatic metastasis of glioma in the brain. It may be concluded that Cyclin A and Ki‑67 may be used as biomarkers to guide the diagnosis of glioma and evaluate the prognosis of affected patients.
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Copy and paste a formatted citation
Spandidos Publications style
Miao C, Wang Z, Yang J, Li J and Gao X: Expression and mutation analysis of Cyclin A and Ki‑67 in glioma and their correlation with tumor progression. Oncol Lett 10: 1716-1720, 2015.
APA
Miao, C., Wang, Z., Yang, J., Li, J., & Gao, X. (2015). Expression and mutation analysis of Cyclin A and Ki‑67 in glioma and their correlation with tumor progression. Oncology Letters, 10, 1716-1720. https://doi.org/10.3892/ol.2015.3474
MLA
Miao, C., Wang, Z., Yang, J., Li, J., Gao, X."Expression and mutation analysis of Cyclin A and Ki‑67 in glioma and their correlation with tumor progression". Oncology Letters 10.3 (2015): 1716-1720.
Chicago
Miao, C., Wang, Z., Yang, J., Li, J., Gao, X."Expression and mutation analysis of Cyclin A and Ki‑67 in glioma and their correlation with tumor progression". Oncology Letters 10, no. 3 (2015): 1716-1720. https://doi.org/10.3892/ol.2015.3474
Copy and paste a formatted citation
x
Spandidos Publications style
Miao C, Wang Z, Yang J, Li J and Gao X: Expression and mutation analysis of Cyclin A and Ki‑67 in glioma and their correlation with tumor progression. Oncol Lett 10: 1716-1720, 2015.
APA
Miao, C., Wang, Z., Yang, J., Li, J., & Gao, X. (2015). Expression and mutation analysis of Cyclin A and Ki‑67 in glioma and their correlation with tumor progression. Oncology Letters, 10, 1716-1720. https://doi.org/10.3892/ol.2015.3474
MLA
Miao, C., Wang, Z., Yang, J., Li, J., Gao, X."Expression and mutation analysis of Cyclin A and Ki‑67 in glioma and their correlation with tumor progression". Oncology Letters 10.3 (2015): 1716-1720.
Chicago
Miao, C., Wang, Z., Yang, J., Li, J., Gao, X."Expression and mutation analysis of Cyclin A and Ki‑67 in glioma and their correlation with tumor progression". Oncology Letters 10, no. 3 (2015): 1716-1720. https://doi.org/10.3892/ol.2015.3474
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