Ruptured thymoma causing a hemothorax: A case report

Hokka,Daisuke; Ogawa,Hiroyuki; Tane,Shinya; Tanaka,Yugo; Tauchi,Shunsuke; Maniwa,Yoshimasa

doi:10.3892/ol.2015.3476

September-2015 Volume 10 Issue 3

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September-2015 Volume 10 Issue 3

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Case Report

Ruptured thymoma causing a hemothorax: A case report

Authors:
- Daisuke Hokka
- Hiroyuki Ogawa
- Shinya Tane
- Yugo Tanaka
- Shunsuke Tauchi
- Yoshimasa Maniwa
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Affiliations: Division of Thoracic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Hyōgo 650-0017, Japan
Pages: 1810-1812
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Published online on: July 8, 2015

https://doi.org/10.3892/ol.2015.3476
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Abstract

A thymoma is a neoplasm that arises from the epithelial cells of the thymus, and may cause various signs and symptoms dependent upon its local extent. A non‑traumatic hemothorax is extremely rare. The present study reports the case of a 77‑year‑old female who presented with an acute onset of chest pain. Imaging procedures revealed a mass occupying the anterior mediastinum and left hemithorax, and a left pleural effusion. Progressive anemia was noted following admission. Left hemothorax due to rupture of the anterior mediastinal mass was suspected, and emergency surgery was performed. Hemorrhage was observed on the cut surface of the tumor. An analysis of frozen sections indicated a thymoma, and a thymo‑partial thymectomy was subsequently performed to remove as much of the hematoma as possible. The patient was discharged on post‑operative day 13 following an uneventful recovery. The present case suggests that in previously healthy individuals, sudden‑onset dyspnea and chest pain co‑occurring with an acute widening of the mediastinum observed on roentgenograph may be indicative of a ruptured thymoma.

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1	Thomas CR, Wright CD and Loehrer PJ: Thymoma: State of the art. J Clin Oncol. 17:2280–2289. 1999.PubMed/NCBI
2	Gerein AN, Srivastava SP and Burgess J: Thymoma: A ten year review. Am J Surg. 136:49–53. 1978. View Article : Google Scholar : PubMed/NCBI
3	Loehrer PJ Sr, Jiroutek M, Aisner S, Aisner J, Green M, Thomas CR Jr, Livingston R and Johnson DH: Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma: An intergroup trial. Cancer. 91:2010–2015. 2001. View Article : Google Scholar : PubMed/NCBI
4	Janik M, Straka L, Krajcovic J, et al: Non-traumatic and spontaneous hemothorax in the setting of forensic medical examination: A systematic literature survey. Forensic Sci Int. 236:22–29. 2014. View Article : Google Scholar : PubMed/NCBI
5	Rosai J and Sobin LH: World Health Organization. International Histological Classification of Tumours: Histological Typing of Tumours of the Thymus. 2nd. Springer-Verlag Berlin Heidelberg; Germany: 1999
6	Okumura M, Ohta M, Tateyama H, et al: The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: A clinical study of 273 patients. Cancer. 94:624–632. 2002. View Article : Google Scholar : PubMed/NCBI
7	Choi SJ, Lee JS, Song KS and Lim TH: Mediastinal teratoma: CT differentiation of ruptured and unruptured tumors. AJR Am J Roentogenol. 171:591–594. 1998. View Article : Google Scholar
8	Sasaka K, Kurihara Y, Nakajima Y, et al: Spontaneous rupture: A complication of benign mature teratomas of the mediastinum. AJR Am J Roentogenol. 170:323–328. 1998. View Article : Google Scholar
9	Caplin JL, Gullan RW, Dymond DS, Bradley SMO, Hill IM and Banim SO: Hemothorax due to rupture of a benign thymoma. Jpn Heart J. 26:123–125. 1985. View Article : Google Scholar : PubMed/NCBI
10	Templeton PA, Vainright JR, Rodriguez A and Diaconis JN: Mediastinal tumors presenting as spontaneous hemothorax, simulating aortic dissection. Chest. 93:828–830. 1988. View Article : Google Scholar : PubMed/NCBI
11	Fukuse T, Matsukura T, Nakamura A, Kosaka S and Tamada J: Mediastinal hematoma due to thymoma hemorrhage - A case report. Nihon Kyobu Geka Gakkai Zasshi. 39:930–934. 1991.(In Japanese). PubMed/NCBI
12	Shimokawa S, Watanabe S, Sakasegawa K and Tani A: Ruptured thymoma causing mediastinal hemorrhage resected via partial sternotomy. Ann Thorac Surg. 71:370–372. 2001. View Article : Google Scholar : PubMed/NCBI
13	Santoprete S, Ragusa M, Urbani M and Puma F: Shock induced by spontaneous rupture of a giant thymoma. Ann Thorac Surg. 83:1526–1528. 2007. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Ruptured thymoma causing a hemothorax: A case report

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