Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient

  • Authors:
    • Muhammad Asif
    • Abrar Hussain
    • Arif Malik
    • Mahmood Rasool
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  • Published online on: July 15, 2015     https://doi.org/10.3892/ol.2015.3495
  • Pages: 1728-1730
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Abstract

Chronic myeloid leukemia (CML) is a disease of the clonal hematopoietic stem cells caused by a balanced translocation between the long arms of chromosomes 9 and 22. Overall, 90‑95% of CML patients present with a Philadelphia (Ph) chromosome t(9;22)(q34;q11) translocation and in addition, variant complex translocations, involving a third chromosome, are observed in 5‑8% of CML patients. Cytogenic testing using bone marrow sample was performed and the FISH test was used for the detection of BCR-ABL fusion gene and complete blood analysis of CML patient was also performed. Results of hematological analysis showed the induced values of white blood cells (168,5000/mm3) and platelets (300,000/mm3) and FISH analysis test showed that 98% cells were positive for BCR/ABL gene translocation. The present study describes a three‑way (1;9;22)(p36;q34;q11) Ph chromosome translocation in a 24‑year‑old female with CML. The patient, who was in the chronic phase of the disease, was treated with daily dose of 400 mg/dl with imatinib mesylateand was monitored constantly at various intervals over a 6‑month period. Many studies reported that certain CML patents with variant translocation responded poorly to imatinib. In the current case report, the CML patient exhibited a suboptimal response to imatinib, denoting a poor prognosis.
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September-2015
Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Asif M, Hussain A, Malik A and Rasool M: Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient. Oncol Lett 10: 1728-1730, 2015
APA
Asif, M., Hussain, A., Malik, A., & Rasool, M. (2015). Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient. Oncology Letters, 10, 1728-1730. https://doi.org/10.3892/ol.2015.3495
MLA
Asif, M., Hussain, A., Malik, A., Rasool, M."Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient". Oncology Letters 10.3 (2015): 1728-1730.
Chicago
Asif, M., Hussain, A., Malik, A., Rasool, M."Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient". Oncology Letters 10, no. 3 (2015): 1728-1730. https://doi.org/10.3892/ol.2015.3495