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Article

Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient

  • Authors:
    • Muhammad Asif
    • Abrar Hussain
    • Arif Malik
    • Mahmood Rasool
  • View Affiliations / Copyright

    Affiliations: Department of Biotechnology and Informatics, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan, Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan, Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia
  • Pages: 1728-1730
    |
    Published online on: July 15, 2015
       https://doi.org/10.3892/ol.2015.3495
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Abstract

Chronic myeloid leukemia (CML) is a disease of the clonal hematopoietic stem cells caused by a balanced translocation between the long arms of chromosomes 9 and 22. Overall, 90‑95% of CML patients present with a Philadelphia (Ph) chromosome t(9;22)(q34;q11) translocation and in addition, variant complex translocations, involving a third chromosome, are observed in 5‑8% of CML patients. Cytogenic testing using bone marrow sample was performed and the FISH test was used for the detection of BCR-ABL fusion gene and complete blood analysis of CML patient was also performed. Results of hematological analysis showed the induced values of white blood cells (168,5000/mm3) and platelets (300,000/mm3) and FISH analysis test showed that 98% cells were positive for BCR/ABL gene translocation. The present study describes a three‑way (1;9;22)(p36;q34;q11) Ph chromosome translocation in a 24‑year‑old female with CML. The patient, who was in the chronic phase of the disease, was treated with daily dose of 400 mg/dl with imatinib mesylateand was monitored constantly at various intervals over a 6‑month period. Many studies reported that certain CML patents with variant translocation responded poorly to imatinib. In the current case report, the CML patient exhibited a suboptimal response to imatinib, denoting a poor prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Asif M, Hussain A, Malik A and Rasool M: Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient. Oncol Lett 10: 1728-1730, 2015.
APA
Asif, M., Hussain, A., Malik, A., & Rasool, M. (2015). Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient. Oncology Letters, 10, 1728-1730. https://doi.org/10.3892/ol.2015.3495
MLA
Asif, M., Hussain, A., Malik, A., Rasool, M."Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient". Oncology Letters 10.3 (2015): 1728-1730.
Chicago
Asif, M., Hussain, A., Malik, A., Rasool, M."Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient". Oncology Letters 10, no. 3 (2015): 1728-1730. https://doi.org/10.3892/ol.2015.3495
Copy and paste a formatted citation
x
Spandidos Publications style
Asif M, Hussain A, Malik A and Rasool M: Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient. Oncol Lett 10: 1728-1730, 2015.
APA
Asif, M., Hussain, A., Malik, A., & Rasool, M. (2015). Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient. Oncology Letters, 10, 1728-1730. https://doi.org/10.3892/ol.2015.3495
MLA
Asif, M., Hussain, A., Malik, A., Rasool, M."Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient". Oncology Letters 10.3 (2015): 1728-1730.
Chicago
Asif, M., Hussain, A., Malik, A., Rasool, M."Three-way complex variant translocation involving short arm chromosome (1;9;22)(p36;q34;q11) in a chronic myeloid leukemia patient". Oncology Letters 10, no. 3 (2015): 1728-1730. https://doi.org/10.3892/ol.2015.3495
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