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High expression level of T-box transcription factor 5 predicts unfavorable survival in stage I and II gastric adenocarcinoma

  • Authors:
    • Yan Zheng
    • Yuan‑Fang Li
    • Wei Wang
    • Yong‑Ming Chen
    • Dan‑Dan Wang
    • Jing‑Jing Zhao
    • Qiu‑Zhong Pan
    • Shan‑Shan Jiang
    • Xiao‑Fei Zhang
    • Shu‑Qiang Yuan
    • Hai‑Bo Qiu
    • Chun‑Yu Huang
    • Bai‑Wei Zhao
    • Zhi‑Wei Zhou
    • Jian‑Chuan Xia

  • View Affiliations / Copyright

    Affiliations: Sun Yat‑sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2021-2026
    |
    Published online on: July 20, 2015
       https://doi.org/10.3892/ol.2015.3515
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Abstract

The expression of T-box transcription factor 5 (TBX5) has previously been observed in human cancer. The aim of the present study was to investigate TBX5 expression and its potential clinical significance in gastric cancer (GC). Using reverse transcription‑quantitative polymerase chain reaction, the TBX5 mRNA expression levels in 30 pairs of surgically resected healthy gastric tissues and early stage (stages I and II) GC tissues were evaluated. The TBX5 mRNA expression levels were increased in GC stage I and II tumor tissues (P=0.01, n=30) compared with the matched adjacent non‑tumor tissue. However, no significant difference was observed in TBX5 mRNA expression levels in matched adjacent non‑tumor tissue compared with the tumor tissue from stage III and IV GC samples (P=0.318, n=30). Immunohistochemical analysis for TBX5 expression was performed on 161 paraffin‑embedded stage I and II GC tissue blocks. Statistical analysis was performed to evaluate the associations between TBX5 expression, clinicopathological factors and prognosis. Patients with stage I and II GC and tumors with high TBX5 expression levels presented poor overall survival (OS) rate (P=0.024). The Cox proportional hazards model analysis demonstrated that TBX5 expression was an independent risk factor (P=0.017). The present study indicates that high expression of TBX5 is associated with unfavorable OS rates in patients with stage I and II GC. In conclusion, the expression of TBX5 may be a valuable biomarker for the selection of cases of high-risk stage I and II GC.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng Y, Li YF, Wang W, Chen YM, Wang DD, Zhao JJ, Pan QZ, Jiang SS, Zhang XF, Yuan SQ, Yuan SQ, et al: High expression level of T-box transcription factor 5 predicts unfavorable survival in stage I and II gastric adenocarcinoma. Oncol Lett 10: 2021-2026, 2015.
APA
Zheng, Y., Li, Y., Wang, W., Chen, Y., Wang, D., Zhao, J. ... Xia, J. (2015). High expression level of T-box transcription factor 5 predicts unfavorable survival in stage I and II gastric adenocarcinoma. Oncology Letters, 10, 2021-2026. https://doi.org/10.3892/ol.2015.3515
MLA
Zheng, Y., Li, Y., Wang, W., Chen, Y., Wang, D., Zhao, J., Pan, Q., Jiang, S., Zhang, X., Yuan, S., Qiu, H., Huang, C., Zhao, B., Zhou, Z., Xia, J."High expression level of T-box transcription factor 5 predicts unfavorable survival in stage I and II gastric adenocarcinoma". Oncology Letters 10.4 (2015): 2021-2026.
Chicago
Zheng, Y., Li, Y., Wang, W., Chen, Y., Wang, D., Zhao, J., Pan, Q., Jiang, S., Zhang, X., Yuan, S., Qiu, H., Huang, C., Zhao, B., Zhou, Z., Xia, J."High expression level of T-box transcription factor 5 predicts unfavorable survival in stage I and II gastric adenocarcinoma". Oncology Letters 10, no. 4 (2015): 2021-2026. https://doi.org/10.3892/ol.2015.3515
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Y, Li YF, Wang W, Chen YM, Wang DD, Zhao JJ, Pan QZ, Jiang SS, Zhang XF, Yuan SQ, Yuan SQ, et al: High expression level of T-box transcription factor 5 predicts unfavorable survival in stage I and II gastric adenocarcinoma. Oncol Lett 10: 2021-2026, 2015.
APA
Zheng, Y., Li, Y., Wang, W., Chen, Y., Wang, D., Zhao, J. ... Xia, J. (2015). High expression level of T-box transcription factor 5 predicts unfavorable survival in stage I and II gastric adenocarcinoma. Oncology Letters, 10, 2021-2026. https://doi.org/10.3892/ol.2015.3515
MLA
Zheng, Y., Li, Y., Wang, W., Chen, Y., Wang, D., Zhao, J., Pan, Q., Jiang, S., Zhang, X., Yuan, S., Qiu, H., Huang, C., Zhao, B., Zhou, Z., Xia, J."High expression level of T-box transcription factor 5 predicts unfavorable survival in stage I and II gastric adenocarcinoma". Oncology Letters 10.4 (2015): 2021-2026.
Chicago
Zheng, Y., Li, Y., Wang, W., Chen, Y., Wang, D., Zhao, J., Pan, Q., Jiang, S., Zhang, X., Yuan, S., Qiu, H., Huang, C., Zhao, B., Zhou, Z., Xia, J."High expression level of T-box transcription factor 5 predicts unfavorable survival in stage I and II gastric adenocarcinoma". Oncology Letters 10, no. 4 (2015): 2021-2026. https://doi.org/10.3892/ol.2015.3515
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