|
1
|
Bielack SS, KempfBielack B, Delling G,
Exner GU, Flege S, Helmke K, Kotz R, SalzerKuntschik M, Werner M,
Winkelmann W, et al: Prognostic factors in high-grade osteosarcoma
of the extremities or trunk: An analysis of 1,702 patients treated
on neoadjuvant cooperative osteosarcoma study group protocols. J
Clin Oncol. 20:776–790. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Friedman MA and Carter SK: The therapy of
osteogenic sarcoma: Current status and thoughts for the future. J
Surg Oncol. 4:482–510. 1972. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Jaffe N: Recent advances in the
chemotherapy of metastatic osteogenic sarcoma. Cancer.
30:1627–1631. 1972. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Cortes EP, Holland JF, Wang JJ, Sinks LF,
Blom J, Senn H, Bank A and Glidewell O: Amputation and adriamycin
in primary osteosarcoma. N Engl J Med. 291:998–1000. 1974.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Clark AM: Natural products as a resource
for new drugs. Pharm Res. 13:1133–1144. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Potterat O and Hamburger M: Drug discovery
and development with plant-derived compounds. Prog Drug Res.
65:47–118. 2008.
|
|
7
|
Sarfaraz S, Adhami VM, Syed DN, Afaq F and
Mukhtar H: Cannabinoids for cancer treatment: Progress and promise.
Cancer Res. 68:339–342. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Guzmán M: Cannabinoids: Potential
anticancer agents. Nat Rev Cancer. 3:745–755. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
EllertMiklaszewska A, Kaminska B and
Konarska L: Cannabinoids down-regulate PI3K/Akt and Erk signalling
pathways and activate proapoptotic function of Bad protein. Cell
Signal. 17:25–37. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Flygare J, Gustafsson K, Kimby E,
Christensson B and Sander B: Cannabinoid receptor ligands mediate
growth inhibition and cell death in mantle cell lymphoma. Febs
Lett. 579:6885–6889. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Ruiz L, Miguel A and Diaz-Laviada I: Delta
(9)-tetrahydrocannabinol induces apoptosis in human prostate PC-3
cells via a receptor-independent mechanism. FEBS Lett. 458:400–404.
1999. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Nithipatikom K, Endsley MP, Isbell MA,
Falck JR, Iwamoto Y, Hillard CJ and Campbell WB:
2-arachidonoylglycerol: A novel inhibitor of androgen-independent
prostate cancer cell invasion. Cancer Res. 64:8826–8830. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Carracedo A, Gironella M, Lorente M,
Garcia S, Guzmán M, Velasco G and Iovanna JL: Cannabinoids induce
apoptosis of pancreatic tumor cells via endoplasmic reticulum
stress-related genes. Cancer Res. 66:6748–6755. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ligresti A, Moriello AS, Starowicz K,
Matias I, Pisanti S, De Petrocellis L, Laezza C, Portella G,
Bifulco M and Di Marzo V: Antitumor activity of plant cannabinoids
with emphasis on the effect of cannabidiol on human breast
carcinoma. J Pharmacol Exp Ther. 318:1375–1387. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Blázquez C, Carracedo A, Barrado L, Real
PJ, Fernández-Luna JL, Velasco G, Malumbres M and Guzmán M:
Cannabinoid receptors as novel targets for the treatment of
melanoma. Faseb J. 20:2633–2635. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Fogli S, Nieri P, Chicca A, Adinolfi B,
Mariotti V, Iacopetti P, Breschi MC and Pellegrini S: Cannabinoid
derivatives induce cell death in pancreatic MIA PaCa-2 cells via a
receptor-independent mechanism. Febs Lett. 580:1733–1739. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Howlett AC, Barth F, Bonner TI, Cabral G,
Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR,
et al: International union of pharmacology. XXVII. Classification
of cannabinoid receptors. Pharmacol Rev. 54:161–202. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Fernández-Ruiz J, Romero J, Velasco G,
Tolón RM, Ramos JA and Guzmán M: Cannabinoid CB2 receptor: A new
target for controlling neural cell survival? Trends Pharmacol Sci.
28:39–45. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Caffarel MM, Sarrió D, Palacios J, Guzman
M and Sánchez C: Delta9-tetrahydrocannabinol inhibits cell cycle
progression in human breast cancer cells through Cdc2 regulation.
Cancer Res. 66:6615–6621. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Takeda S, Okajima S, Miyoshi H, Yoshida K,
Okamoto Y, Okada T, Amamoto T, Watanabe K, Omiecinski CJ and
Aramaki H: Cannabidiolic acid, a major cannabinoid in fiber-type
cannabis, is an inhibitor of MDA-MB-231 breast cancer cell
migration. Toxicol Lett. 214:314–319. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Carracedo A, Lorente M, Egia A, Blázquez
C, García S, Giroux V, Malicet C, Villuendas R, Gironella M,
González-Feria L, et al: The stress-regulated protein p8 mediates
cannabinoid-induced apoptosis of tumor cells. Cancer Cell.
9:301–312. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Torres S, Lorente M, Rodríguez-Fornés F,
Hernández-Tiedra S, Salazar M, García-Taboada E, Barcia J, Guzmán M
and Velasco G: A combined preclinical therapy of cannabinoids and
temozolomide against glioma. Mol Cancer Ther. 10:90–103. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2 (-Delta Delta C (T) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Sarfaraz S, Afaq F, Adhami VM, Malik A and
Mukhtar H: Cannabinoid receptor agonist-induced apoptosis of human
prostate cancer cells LNCaP proceeds through sustained activation
of ERK1/2 leading to G1 cell cycle arrest. J Biol Chem.
281:39480–39491. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Mackie K: Cannabinoid receptors as
therapeutic targets. Annu. Rev Pharmacol Toxicol. 46:101–122. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Pertwee RG: Emerging strategies for
exploiting cannabinoid receptor agonists as medicines. Br J
Pharmacol. 156:397–411. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Hall W, Christie M and Currow D:
Cannabinoids and cancer: Causation, remediation and palliation. The
lancet oncology. 6:35–42. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Wang YH, Han XD, Qiu Y, Xiong J, Yu Y,
Wang B, Zhu ZZ, Qian BP, Chen YX, Wang SF, et al: Increased
expression of insulin-like growth factor-1 receptor is correlated
with tumor metastasis and prognosis in patients with osteosarcoma.
J Surg Oncol. 105:235–243. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Preet A, Ganju R and Groopman J:
Delta9-Tetrahydrocannabinol inhibits epithelial growth
factor-induced lung cancer cell migration in vitro as well as its
growth and metastasis in vivo. Oncogene. 27:339–346. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Berx G, Nollet F and Van Roy F:
Dysregulation of the E-cadherin/catenin complex by irreversible
mutations in human carcinomas. Cell Adhes Commun. 6:171–184. 1998.
View Article : Google Scholar : PubMed/NCBI
|
|
31
|
ArtavanisTsakonas S, Rand MD and Lake RJ:
Notch signaling: Cell fate control and signal integration in
development. Science. 284:770–776. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Wang J, Fu L, Gu F and Ma Y: Notch1 is
involved in migration and invasion of human breast cancer cells.
Oncol Rep. 26:1295–1303. 2011.PubMed/NCBI
|
|
33
|
Curran S and Murray G: Matrix
metalloproteinases: Molecular aspects of their roles in tumour
invasion and metastasis. Eur J Cancer. 36:1621–1630. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
John A and Tuszynski G: The role of matrix
metalloproteinases in tumor angiogenesis and tumor metastasis.
Pathology oncology research. 7:14–23. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Nagakawa Y, Aoki T, Kasuya K, Tsuchida A
and Koyanagi Y: Histologic features of venous invasion, expression
of vascular endothelial growth factor and matrix
metalloproteinase-2 and matrix metalloproteinase-9 and the relation
with liver metastasis in pancreatic cancer. Pancreas. 24:169–178.
2002. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Xiong HQ, Abbruzzese JL, Lin E, Wang L,
Zheng L and Xie K: NF-kappaaB activity blockade impairs the
angiogenic potential of human pancreatic cancer cells. Int J
Cancer. 108:181–188. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Dong Z, Bonfil RD, Chinni S, Deng X,
Trindade Filho JC, Bernardo M, Vaishampayan U, Che M, Sloane BF,
Sheng S, et al: Matrix metalloproteinase activity and osteoclasts
in experimental prostate cancer bone metastasis tissue. Am J
Pathol. 166:1173–1186. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Wang Z, Banerjee S, Li Y, Rahman KM, Zhang
Y and Sarkar FH: Down-regulation of notch-1 inhibits invasion by
inactivation of nuclear factor-kappaB, vascular endothelial growth
factor and matrix metalloproteinase-9 in pancreatic cancer cells.
Cancer Res. 66:2778–2784. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Jezierska A and Motyl T: Matrix
metalloproteinase-2 involvement in breast cancer progression: A
mini-review. Med Sci Monit. 15:RA32–RA40. 2009.PubMed/NCBI
|
|
40
|
Ramer R and Hinz B: Inhibition of cancer
cell invasion by cannabinoids via increased expression of tissue
inhibitor of matrix metalloproteinases-1. J Natl Cancer Inst.
100:59–69. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
MachadoRocha FC, Dos Dos Santos Júnior JG,
Stefano SC and da Silveira DX: Systematic review of the literature
on clinical and experimental trials on the antitumor effects of
cannabinoids in gliomas. J Neurooncol. 116:11–24. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Kogan NM, Blázquez C, Alvarez L, Gallily
R, Schlesinger M, Guzmán M and Mechoulam R: A cannabinoid quinone
inhibits angiogenesis by targeting vascular endothelial cells.
Molecular Pharmacology. 70:51–59. 2006.PubMed/NCBI
|
|
43
|
Joo YE, Sohn YH, Lee WS, Park CH, Choi SK,
Rew JS, Park CS and Kim SJ: Expression of vascular endothelial
growth factor and p53 in pancreatic carcinomas. Korean J Intern
Med. 17:153–159. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Zeng H, Datta K, Neid M, Li J, Parangi S
and Mukhopadhyay D: Requirement of different signaling pathways
mediated by insulin-like growth factor-I receptor for
proliferation, invasion and VPF/VEGF expression in a pancreatic
carcinoma cell line. Biochem Biophys Res Commun. 302:46–55. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Fujioka S, Sclabas GM, Schmidt C, Niu J,
Frederick WA, Dong QG, Abbruzzese JL, Evans DB, Baker C and Chiao
PJ: Inhibition of constitutive NF-kappa B activity by I kappa B
alpha M suppresses tumorigenesis. Oncogene. 22:1365–1370. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Wey JS, Fan F, Gray MJ, Bauer TW, McCarty
MF, Somcio R, Liu W, Evans DB, Wu Y, Hicklin DJ, et al: Vascular
endothelial growth factor receptor-1 promotes migration and
invasion in pancreatic carcinoma cell lines. Cancer. 104:427–438.
2005. View Article : Google Scholar : PubMed/NCBI
|
