Low-grade cribriform cystadenocarcinoma of the palatal gland: A case report

Kokabu,Shoichiro; Nojima,Junya; Kayano,Hidekazu; Yoda,Testuya

doi:10.3892/ol.2015.3528

Low-grade cribriform cystadenocarcinoma of the palatal gland: A case report

Authors:
- Shoichiro Kokabu
- Junya Nojima
- Hidekazu Kayano
- Testuya Yoda
View Affiliations

Affiliations: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University, Moroyama, Saitama 350‑0495, Japan, Department of Pathology, Faculty of Medicine, Saitama Medical University, Moroyama, Saitama 350‑0495, Japan
Published online on: July 23, 2015 https://doi.org/10.3892/ol.2015.3528
Pages: 2453-2457

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Low-grade cribriform cystadenocarcinoma (LGCCC) is a malignant salivary gland tumor. LGCCC occurs rarely, with the parotid gland being the most commonly afflicted site. Few cases arise in other sites. The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. A 56‑year‑old female was referred to Saitama Medical University Hospital (Moroyama, Saitama, Japan) due to an intraoral mass. Since cytological examination and biopsy led to a diagnosis favoring a neoplasm, but with uncertain malignant potential, the tumor was resected with a safe surgical margin. The specimen was thoroughly examined. Microscopically, there was a well‑demarcated, unilocular cyst with the lumen lined by tumor cells. The tumor cells were arranged in tubular, cribriform and solid structures in the area of the intracystic mass lesions. Nuclear atypia was inconspicuous, although mitotic figures were observed throughout the tumor. Neither local nor perineural invasion was present. On immunohistochemistry, the tumor cells were diffusely positive for S‑100 protein. Myoepithelial markers, calponin and p63, highlighted the cells rimming the cystic mass. The final histopathological diagnosis was of LGCCC. The tumor was completely resected. At 1 year post‑resection, the patient exhibited no recurrence or distant metastasis. LGCCC is regarded as clinically indolent. However, there is little literature available to aid with prognosis prediction due to the rarity of LGCCC cases. Thus, greater experience and longer follow-up periods are necessary to find the optimal/curative treatment for patients with LGCCC and to clarify the pathophysiology.

View Figures

View References

1	BrandweinGensler MS and Gnepp DR: Low-grade cribriform cystadenocarcinoma. World Health Organization Classification of TumoursPathology and Genetics Head and Neck Tumors. Barnes L, Eveson JW, Reichart P and Sidransky D: IARC Press; Lyon: pp. 2332005
2	Delgado R, Klimstra D and Albores-Saavedra J: Low grade salivary duct carcinoma. A distinctive variant with a low grade histology and a predominant intraductal growth pattern. Cancer. 78:958–967. 1996. View Article : Google Scholar : PubMed/NCBI
3	BrandweinGensler M, Hille J, Wang BY, Urken M, Gordon R, Wang LJ, Simpson JR, Simpson RH and Gnepp DR: Low-grade salivary duct carcinoma: Description of 16 cases. Am J Surg Pathol. 28:1040–1044. 2004. View Article : Google Scholar : PubMed/NCBI
4	Weinreb I, TabandaLichauco R, Van der Kwast T and Perez-Ordoñez B: Low-grade intraductal carcinoma of salivary gland: Report of 3 cases with marked apocrine differentiation. Am J Surg Pathol. 30:1014–1021. 2006. View Article : Google Scholar : PubMed/NCBI
5	Arai A, Taki M, Mimaki S, Ueda M and Hori S: Low-grade cribriform cystadenocarcinoma of the parotid gland: A case report. Auris Nasus Larynx. 36:725–728. 2009. View Article : Google Scholar : PubMed/NCBI
6	Nakatsuka S, Harada H, Fujiyama H, Takeda K, Kitamura K, Kimura H, Nagano T, Ito M and Asada Y: An invasive adenocarcinoma of the accessory parotid gland: A rare example developing from a low-grade cribriform cystadenocarcinoma? Diagn Pathol. 6:1222011. View Article : Google Scholar : PubMed/NCBI
7	Wang L, Liu Y, Lin X, Zhang D, Li Q, Qiu X and Wang EH: Low-grade cribriform cystadenocarcinoma of salivary glands: Report of two cases and review of the literature. Diagn Pathol. 8:282013. View Article : Google Scholar : PubMed/NCBI
8	Tatemoto Y, Ohno A and Osaki T: Low malignant intraductal carcinoma on the hard palate: A variant of salivary duct carcinoma? Eur J Cancer B Oral Oncol. 32B:275–277. 1996. View Article : Google Scholar : PubMed/NCBI
9	Laco J, Podhola M and Dolezalova H: Low-grade cribriform cystadenocarcinoma of the parotid gland: A neoplasm with favorable prognosis, distinct from salivary duct carcinoma. Int J Surg Pathol. 18:369–373. 2010.PubMed/NCBI
10	Nakazawa T, Kondo T, Yuminomochi T, Nakazawa K, Ishii Y, Mochizuki K, Kawasaki T, Yamane T, Miyata M, Motosugi U and Katoh R: Fine-needle aspiration biopsy of low-grade cribriform cystadenocarcinoma of the salivary gland. Diagn Cytopathol. 39:218–222. 2011.PubMed/NCBI
11	Kusafuka K, Itoh H, Sugiyama C and Nakajima T: Low-grade salivary duct carcinoma of the parotid gland: Report of a case with immunohistochemical analysis. Med Mol Morphol. 43:178–184. 2010. View Article : Google Scholar : PubMed/NCBI
12	Weinreb I: Intraductal carcinoma of salivary gland (so-called low-grade cribriform cystadenocarcinoma) arising in an intraparotid lymph node. Head Neck Pathol. 5:321–325. 2011. View Article : Google Scholar : PubMed/NCBI
13	Projetti F, LacroixTriki M, Serrano E, Vergez S, Barres BH, Meilleroux J, Delisle MB and Uro-Coste E: A comparative immunohistochemistry study of diagnostic tools in salivary gland tumors: Usefulness of mammaglobin, gross cystic disease fluid protein 15, and p63 cytoplasmic staining for the diagnosis of mammary analog secretory carcinoma? J Oral Pathol Med. 44:244–251. 2014. View Article : Google Scholar : PubMed/NCBI
14	Obokata A, Sakurai S, Hirato J, Sakamoto K, Takekoshi T and Aoki J: Cytologic features of low-grade cribriform cystadenocarcinoma of the submandibular gland: A case report. Acta Cytol. 57:207–212. 2013. View Article : Google Scholar : PubMed/NCBI
15	Foss RD, Ellis GL and Auclair PL: Salivary gland cystadenocarcinomas. A clinicopathologic study of 57 cases = Am J Surg Pathol. 20:1440–1447. 1996.
16	Takahashi H, Fujita S, Okabe H, Tsuda N and Tezuka F: Distribution of tissue markers in acinic cell carcinomas of salivary gland. Pathol Res Pract. 188:692–700. 1992. View Article : Google Scholar : PubMed/NCBI
17	Anderson C, Muller R, Piorkowski R, Knibbs DR and Vignoti P: Intraductal carcinoma of major salivary gland. Cancer. 69:609–614. 1992. View Article : Google Scholar : PubMed/NCBI
18	Eversole LR: Histogenic classification of salivary tumors. Arch Pathol. 92:433–443. 1971.PubMed/NCBI
19	Regezi JA and Batsakis JG: Histogenesis of salivary gland neoplasms. Otolaryngol Clin North Am. 10:297–307. 1977.PubMed/NCBI
20	Sato M, Hayashi Y, Yoshida H, Yanagawa T, Yura Y and Nitta T: Search for specific markers of neoplastic epithelial duct and myoepithelial cell lines established from human salivary gland and characterization of their growth in vitro. Cancer. 54:2959–2967. 1984. View Article : Google Scholar : PubMed/NCBI
21	Hayashi Y, Yanagawa T, Yoshida H, Yura Y, Nitta T and Sato M: Induction of other differentiation stages in neoplastic epithelial duct and myoepithelial cells from the human salivary gland grown in athymic nude mice. Cancer. 55:2575–2583. 1985. View Article : Google Scholar : PubMed/NCBI
22	Bahrami A, PerezOrdonez B, Dalton JD and Weinreb I: An analysis of PLAG1 and HMGA2 rearrangements in salivary duct carcinoma and examination of the role of precursor lesions. Histopathology. 63:250–262. 2013. View Article : Google Scholar : PubMed/NCBI