microRNA-195 inhibits the proliferation, migration and invasion of cervical cancer cells via the inhibition of CCND2 and MYB expression

  • Authors:
    • Xinjie Du
    • Li Lin
    • Lijun Zhang
    • Jie Jiang
  • View Affiliations

  • Published online on: July 29, 2015     https://doi.org/10.3892/ol.2015.3541
  • Pages: 2639-2643
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Abstract

The functions of microRNAs (miRNA/miR) in the development of cervical cancer remain largely undefined. The present study investigated the role of miR‑195 in cervical cancer development. The expression of miR‑195 mimics in the cervical cancer HeLa cell line significantly decreased the cell proliferation, migration and invasion capacities in vitro. Using miRNA target prediction algorithms and reporter assays, cyclin D2 (CCND2) and v‑myb avian myeloblastosis viral oncogene homolog (MYB) were identified as direct targets of miR‑195. Moreover, miR‑195 repressed the expression of CCND2 and MYB in the HeLa cells at the mRNA and protein levels. Finally, the expression of miR‑195 was downregulated in cervical cancer tissues compared with normal tissues. Together, these data suggest that miR-195 is a tumor suppressor in cervical cancer.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Du X, Lin L, Zhang L and Jiang J: microRNA-195 inhibits the proliferation, migration and invasion of cervical cancer cells via the inhibition of CCND2 and MYB expression. Oncol Lett 10: 2639-2643, 2015
APA
Du, X., Lin, L., Zhang, L., & Jiang, J. (2015). microRNA-195 inhibits the proliferation, migration and invasion of cervical cancer cells via the inhibition of CCND2 and MYB expression. Oncology Letters, 10, 2639-2643. https://doi.org/10.3892/ol.2015.3541
MLA
Du, X., Lin, L., Zhang, L., Jiang, J."microRNA-195 inhibits the proliferation, migration and invasion of cervical cancer cells via the inhibition of CCND2 and MYB expression". Oncology Letters 10.4 (2015): 2639-2643.
Chicago
Du, X., Lin, L., Zhang, L., Jiang, J."microRNA-195 inhibits the proliferation, migration and invasion of cervical cancer cells via the inhibition of CCND2 and MYB expression". Oncology Letters 10, no. 4 (2015): 2639-2643. https://doi.org/10.3892/ol.2015.3541